AutismKB 2.0

Annotation Detail for ATR


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Basic Information Top
Gene Symbol:ATR ( FRP1,MEC1,SCKL,SCKL1 )
Gene Full Name: ataxia telangiectasia and Rad3 related
Band: 3q23
Quick LinksEntrez ID:545; OMIM: 601215; Uniprot ID:ATR_HUMAN; ENSEMBL ID: ENSG00000175054; HGNC ID: 882
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
428Phosphoserine.
435Phosphoserine.
919Phosphoserine.
1989Phosphothreonine.
Location(AA) Modifications Resource
1989PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
26Phosphotyrosine(Abl)HMM predict
28Phosphothreonine(PKC)HMM predict
61Phosphoserine(ATM)HMM predict
61Phosphoserine(IKK)HMM predict
85N-linkedHMM predict
188Phosphotyrosine(Jak)HMM predict
241Phosphoserine(CDC2)HMM predict
310Phosphotyrosine(INSR)HMM predict
419N-linkedHMM predict
421Phosphoserine(CK1)HMM predict
423N-linkedHMM predict
435PhosphoserineHMM predict
435Phosphoserine(PKG)HMM predict
439N-linkedHMM predict
441Phosphoserine(CDK)HMM predict
448Phosphothreonine(PKC)HMM predict
479Phosphotyrosine(Jak)HMM predict
549Phosphoserine(IKK)HMM predict
549Phosphoserine(CK1)HMM predict
579N-linkedHMM predict
628Phosphotyrosine(Jak)HMM predict
629Phosphoserine(IKK)HMM predict
776Phosphoserine(CDC2)HMM predict
902Phosphoserine(CAMK2)HMM predict
902PhosphoserineHMM predict
944Phosphoserine(ATM)HMM predict
1007PhosphoserineHMM predict
1007Phosphoserine(IKK)HMM predict
1058N-linkedHMM predict
1107Phosphotyrosine(Syk)HMM predict
1236Phosphotyrosine(Jak)HMM predict
1253SulfotyrosineHMM predict
1271Phosphotyrosine(EGFR)HMM predict
1276Phosphoserine(CK2)HMM predict
1278PhosphoserineHMM predict
1333Phosphoserine(ATM)HMM predict
1464Phosphoserine(CDK)HMM predict
1465Phosphoserine(ATM)HMM predict
1549Phosphotyrosine(Syk)HMM predict
1623Phosphotyrosine(Syk)HMM predict
1623SulfotyrosineHMM predict
1626Phosphotyrosine(Syk)HMM predict
1762N-linkedHMM predict
1773Phosphotyrosine(INSR)HMM predict
1875Phosphoserine(CK2)HMM predict
1876PhosphoserineHMM predict
1876Phosphoserine(ATM)HMM predict
1876Phosphoserine(IKK)HMM predict
1880Phosphoserine(CK1)HMM predict
1916Phosphotyrosine(INSR)HMM predict
1987N-linkedHMM predict
1989Phosphothreonine(CDC2)HMM predict
2084Phosphotyrosine(EGFR)HMM predict
2102Phosphotyrosine(SRC)HMM predict
2132Phosphotyrosine(Syk)HMM predict
2132Phosphotyrosine(INSR)HMM predict
2207Phosphoserine(PKG)HMM predict
2235O-linkedHMM predict
2381N-linkedHMM predict
2382N-linkedHMM predict
2400Phosphotyrosine(INSR)HMM predict
2402Phosphothreonine(PKC)HMM predict
2448O-linkedHMM predict
2449Phosphoserine(IKK)HMM predict
2578N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001184
  • Location:chr3 143650769-143780340
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 143788438 143788704 266 8231
CTCF CD4SISSRdata 143788438 143788704 266 8231
CTCF G2GSE9613 143788267 143788672 405 8129
CTCF G2GSE9613 143797843 143798087 244 17625
FOXA1 MCF7GSE15244 143781128 143781308 180 878
FOXA1 MCF7GSE15244 143783296 143783475 179 3045
H3K4me3 colorectalcancer 143780581 143781241 660 571
H3ac HepG2E 143782835 143783475 640 2815
H3ac HepG2E 143797914 143798859 945 18046
H3ac HepG2E 143799367 143799947 580 19317
LIN9 G0GSE7516 143780108 143780982 874 205
Myc K562GSE19551 143788335 143788781 446 8218
Nanog hESGSE18292 143788274 143788652 378 8123
P300 T30-glioblastomaGSE21026 143779583 143781389 1806 146
P300 T30-glioblastomaGSE21026 143788170 143788858 688 8174
P300 T30-glioblastomaGSE21026 143796964 143798192 1228 17238
RARA MCF7GSE15244 143783223 143783475 252 3009
Rb GrowingGSE19898 143797600 143797903 303 17411
TAFII hESGSE17917 143797541 143798231 690 17546
TFAP2C MCF7GSE21234 143790585 143790854 269 10379
hScc1 BcellGSE12603 143797757 143798162 405 17619
hScc1 CdLSGSE12603 143788416 143788822 406 8279
hScc1 G2GSE9613 143788305 143788822 517 8223
p130 QuiescentGSE19898 143780048 143780659 611 13
p130 shRbQuiescentGSE19898 143797474 143797847 373 17320
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 143779863 143780284 421 0
ETS1 JurkatGSE17954 143779509 143780960 1451 0
FOXA1 MCF7GSE15244 143702565 143702986 421 0
FOXA1 MCF7GSE15244 143779313 143780181 868 0
H3K4me3 colorectalcancer 143778813 143779930 1117 0
H3ac HepG2E 143778813 143781308 2495 0
Myc hESGSE17917 143780057 143780444 387 0
Oct1 HelaGSE14283 143703858 143703908 50 0
Oct1 HelaGSE14283 143713536 143713566 30 0
PHF8 293TGSE20725 143779637 143780977 1340 0
PHF8 HeLaGSE20725 143779755 143780798 1043 0
RARA MCF7GSE15244 143702565 143702986 421 0
RARA MCF7GSE15244 143779460 143780181 721 0
RARG MCF7GSE15244 143779385 143779966 581 0
Rb SenescentGSE19898 143780020 143780591 571 0
TAF HelaGSE8489 143778953 143779899 946 0
TAF k562GSE8489 143778630 143779966 1336 0
hScc1 BcellGSE12603 143779966 143780393 427 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-221 hsa-mir-221 X 20203269
hsa-miR-221* hsa-mir-221 X 20203269
hsa-miR-222 hsa-mir-222 X 20203269
hsa-miR-222* hsa-mir-222 X 20203269
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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