AutismKB 2.0

Annotation Detail for PPARA


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Basic Information Top
Gene Symbol:PPARA ( MGC2237,MGC2452,NR1C1,PPAR,PPARalpha,hPPAR )
Gene Full Name: peroxisome proliferator-activated receptor alpha
Band: 22q13.31
Quick LinksEntrez ID:5465; OMIM: 170998; Uniprot ID:PPARA_HUMAN; ENSEMBL ID: ENSG00000186951; HGNC ID: 9232
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
12Phosphoserine(MAPK)HMM predict
12Phosphoserine(CDC2)HMM predict
38Phosphoserine(ATM)HMM predict
73Phosphoserine(IKK)HMM predict
73Phosphoserine(ATM)HMM predict
76O-linkedHMM predict
76O-linkedHMM predict
77O-linkedHMM predict
77Phosphoserine(CDC2)HMM predict
79Phosphoserine(CK1)HMM predict
79O-linkedHMM predict
80Phosphoserine(IKK)HMM predict
82O-linkedHMM predict
93Phosphoserine(CDK)HMM predict
234Phosphoserine(PKG)HMM predict
276S-palmitoylHMM predict
464Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001001928
  • Location:chr22 44925162-45018316
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 44905656 44906361 705 19154
H3ac HepG2E 44922889 44923899 1010 1769
STAT1 IFNSISSRdata 44922862 44923620 758 1922
USF1 HepG2E 44914755 44916383 1628 9594
hScc1 BcellGSE12603 44906660 44906795 135 18435
hScc1 BcellGSE12603 44908103 44908787 684 16718
hScc1 BcellGSE12603 44923930 44924873 943 761
p63 keratinocytesGSE17611 44921904 44923334 1430 2544
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 45012792 45016573 3781 0
ER Breast-CancerGSE22609 44926095 44926644 549 0
FOXA1 MCF7GSE15244 44936751 44937906 1155 0
Fos K562GSE19551 44940473 44940868 395 0
FoxA1 MCF7MACSdata 44953397 44953519 122 0
Gata2 K562GSE18868 45014335 45014743 408 0
NRSF mAbJurkat 44929586 44929835 249 0
Nanog ESGSE20650 44975861 44976441 580 0
RARG MCF7GSE15244 44968348 44968754 406 0
hScc1 CdLSGSE12603 44925617 44926017 400 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7c hsa-let-7c 21 18006136
hsa-let-7c hsa-let-7c 21 17690133
hsa-let-7c hsa-let-7c 21 17438130
hsa-let-7c* hsa-let-7c 21 18006136
hsa-let-7c* hsa-let-7c 21 17690133
hsa-let-7c* hsa-let-7c 21 17438130
hsa-miR-103 hsa-mir-103-2 20 19011694
hsa-miR-103 hsa-mir-103-1 5 19011694
hsa-miR-10b hsa-mir-10b 2 19780876
hsa-miR-10b* hsa-mir-10b 2 19780876
hsa-miR-122 hsa-mir-122 18 19487572
hsa-miR-122* hsa-mir-122 18 19487572
hsa-miR-17 hsa-mir-17 13 17438130
hsa-miR-17* hsa-mir-17 13 17438130
hsa-miR-206 hsa-mir-206 6 19074574
hsa-miR-21 hsa-mir-21 17 20693317
hsa-miR-21* hsa-mir-21 17 20693317
hsa-miR-22 hsa-mir-22 17 19011694
hsa-miR-22 hsa-mir-22 17 18347104
hsa-miR-22* hsa-mir-22 17 19011694
hsa-miR-22* hsa-mir-22 17 18347104
hsa-miR-29a hsa-mir-29a 7 20164119
hsa-miR-29a* hsa-mir-29a 7 20164119
hsa-miR-29b hsa-mir-29b-1 7 20164119
hsa-miR-29b hsa-mir-29b-2 1 20164119
hsa-miR-29b-1* hsa-mir-29b-1 7 20164119
hsa-miR-29b-2* hsa-mir-29b-2 1 20164119
hsa-miR-29c hsa-mir-29c 1 20164119
hsa-miR-29c* hsa-mir-29c 1 20164119
hsa-miR-519d hsa-mir-519d 19 20057369
hsa-miR-92a hsa-mir-92a-1 13 17438130
hsa-miR-92a hsa-mir-92a-2 X 17438130
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
17609 mRNA PPARA chr22 44867017 44960172 1773 mRNA LOC150383 chr22 44958399 44962140Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018