Annotation Detail for CROT

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	CROT ( COT )
Gene Full Name:	carnitine O-octanoyltransferase
Band:	7q21.12
Quick Links	Entrez ID:54677; OMIM: 606090; Uniprot ID:OCTC_HUMAN; ENSEMBL ID: ENSG00000005469; HGNC ID: 2366
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:13 results

Location(AA)	Modification
495	N6-acetyllysine (By similarity).
612	Microbody targeting signal (Potential).

Location(AA)	Modification	Resource
16	Sulfotyrosine	HMM predict
48	Phosphotyrosine(Syk)	HMM predict
48	Phosphotyrosine(EGFR)	HMM predict
152	Phosphothreonine(MAPK)	HMM predict
188	Phosphoserine(ATM)	HMM predict
213	Phosphothreonine(MAPK)	HMM predict
213	Phosphothreonine(CDK)	HMM predict
230	Phosphoserine(CK1)	HMM predict
281	Phosphoserine(CK1)	HMM predict
282	Phosphoserine(ATM)	HMM predict
290	Phosphotyrosine(INSR)	HMM predict
531	Phosphoserine(CK1)	HMM predict
583	Phosphoserine(IKK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_021151
Location:chr7 86812946-86867044
strand:+

Upstream the gene:10 results
Downstream the gene:0 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	86812548	86812899	351	223
Gata2	K562	GSE18868	86798159	86798653	494	14541
H3K4me3	colorectal	cancer	86811984	86812410	426	750
Myc	K562	GSE19551	86795646	86795878	232	17185
Oct1	H2O2-Hela	GSE14283	86810318	86810346	28	2615
PHF8	HeLa	GSE20725	86812082	86813406	1324	203
Rb	Senescent	GSE19898	86812762	86813006	244	63
Rb	shRbSenescence	GSE19898	86812512	86812846	334	268
TFAP2C	MCF7	GSE21234	86806704	86807122	418	6034
p130	shRbQuiescent	GSE19898	86812244	86812962	718	344

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	86812495	86813487	992	0
H3K4me3	colorectal	cancer	86812965	86813519	554	0
H3ac	HepG2	E	86813012	86813600	588	0
Myc	K562	GSE19551	86823792	86824032	240	0
P300	T0-glioblastoma	GSE21026	86842837	86844178	1341	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-33a	hsa-mir-33a	22	20732877
hsa-miR-33a*	hsa-mir-33a	22	20732877

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
24264	mRNA	CROT	chr7	86619661	86673760	71	EST		chr7	86615544	86619732	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved