Annotation Detail for PPIB

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Basic Information Top

Gene Symbol:	PPIB ( CYP-S1,CYPB,MGC14109,MGC2224,OI9,SCYLP )
Gene Full Name:	peptidylprolyl isomerase B (cyclophilin B)
Band:	15q22.31
Quick Links	Entrez ID:5479; OMIM: 123841; Uniprot ID:PPIB_HUMAN; ENSEMBL ID: ENSG00000166794; HGNC ID: 9255
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
148	N-linked (GlcNAc...) (Potential).
216	Prevents secretion from ER.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	62242482	62242705	223	187
CTCF	CD4	SISSRdata	62242482	62242705	223	187
CTCF	G2	GSE9613	62242067	62242892	825	73
ETS1	Jurkat	GSE17954	62241903	62243229	1326	160
H3ac	HepG2	E	62242597	62243704	1107	744
VDR	GM10861-Unstim	GSE22484	62241100	62244235	3135	261
VDR	GM10861-stim	GSE22484	62240752	62244600	3848	270
hScc1	Bcell	GSE12603	62242126	62242981	855	147
hScc1	CdLS	GSE12603	62241992	62243020	1028	100

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
H3K4me3	colorectal	cancer	62241134	62241952	818
H3ac	HepG2	E	62241134	62241952	818
PHF8	HeLa	GSE20725	62241599	62242870	1271
PHF8	Hs68plusFBS	GSE20725	62241485	62243266	1781

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1183	Unknown	pSILAC	miR-1	PPIB	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000166794		n_a	n_a	n_a	"epithelium, lymphocyte, leukocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
8936	HTC	SNX22	chr15	62232731	62236732	515	mRNA	PPIB	chr15	62235067	62242407	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018