AutismKB 2.0

Annotation Detail for CDKAL1


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Basic Information Top
Gene Symbol:CDKAL1 ( FLJ20342,FLJ46705,MGC75469 )
Gene Full Name: CDK5 regulatory subunit associated protein 1-like 1
Band: 6p22.3
Quick LinksEntrez ID:54901; OMIM: 611259; Uniprot ID:CDKAL_HUMAN; ENSEMBL ID: ENSG00000145996; HGNC ID: 21050
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
499Phosphothreonine.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_017774
  • Location:chr6 20642666-21339742
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 20637455 20637620 165 5129
CTCF CD4SISSRdata 20637455 20637620 165 5129
CTCF G2GSE9613 20636744 20636984 240 5803
Oct1 HelaGSE14283 20629103 20629154 51 13538
P300 T30-glioblastomaGSE21026 20642154 20643105 951 37
Rb shRbQuiescentGSE19898 20642470 20642838 368 13
hScc1 CdLSGSE12603 20636706 20636984 278 5822
hScc1 CdLSGSE12603 20637465 20637732 267 5068
p130 shRbSenescentGSE19898 20642456 20642857 401 10
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 21354237 21354401 164 14577
Oct1 H2O2-HelaGSE14283 21350861 21350894 33 11135
Oct1 HelaGSE14283 21350862 21350894 32 11136
hScc1 G2GSE9613 21354237 21354401 164 14577
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 21300040 21300398 358 0
CBP T30-glioblastomaGSE21026 20919120 20920143 1023 0
CBP T30-glioblastomaGSE21026 21211827 21212423 596 0
CTCF G2GSE9613 21307244 21307613 369 0
ER MCF7GSE19013 20801932 20802385 453 0
ETS1 JurkatGSE17954 20642264 20643455 1191 0
FOXA1 MCF7GSE15244 21041286 21041705 419 0
FOXA1 MCF7GSE15244 21211498 21212586 1088 0
FOXA1 MCF7GSE15244 21219357 21220059 702 0
Fos K562GSE19551 20858626 20858997 371 0
Fos K562GSE19551 20919309 20920049 740 0
Fos K562GSE19551 20954657 20955308 651 0
Fos K562GSE19551 21161953 21162267 314 0
Fos K562GSE19551 21175781 21176131 350 0
FoxA1 MCF7MACSdata 20908585 20908744 159 0
FoxA1 MCF7MACSdata 21115959 21116182 223 0
FoxA1 MCF7MACSdata 21211837 21212146 309 0
FoxA1 MCF7MACSdata 21219597 21219857 260 0
Gata2 K562GSE18868 20683393 20683713 320 0
Gata2 K562GSE18868 21209736 21210328 592 0
H3K4me3 colorectalcancer 20642505 20643807 1302 0
H3ac HepG2E 20642505 20643976 1471 0
Myc K562GSE19551 20642473 20643147 674 0
Myc K562GSE19551 20954775 20955152 377 0
NFkBII GM12878GSE19485 21169394 21171302 1908 0
Nanog ESGSE20650 20642489 20642904 415 0
Nanog hESGSE18292 20919420 20919705 285 0
Nanog hESGSE18292 21094151 21094435 284 0
Nanog hESGSE18292 21293967 21294766 799 0
Oct1 H2O2-HelaGSE14283 20970641 20970684 43 0
Oct1 H2O2-HelaGSE14283 21304605 21304638 33 0
Oct1 HelaGSE14283 20687331 20687365 34 0
Oct1 HelaGSE14283 20871345 20871380 35 0
Oct1 HelaGSE14283 20876445 20876482 37 0
Oct1 HelaGSE14283 20888676 20888704 28 0
Oct1 HelaGSE14283 20904307 20904371 64 0
Oct1 HelaGSE14283 20931849 20931881 32 0
Oct1 HelaGSE14283 20970642 20970675 33 0
Oct1 HelaGSE14283 21003574 21003602 28 0
Oct1 HelaGSE14283 21336318 21336366 48 0
Oct4 hESGSE17917 20737823 20738102 279 0
Oct4 hESGSE21916 21294003 21294721 718 0
P300 T0-glioblastomaGSE21026 20642122 20643226 1104 0
P300 T0-glioblastomaGSE21026 21211643 21212382 739 0
P300 T30-glioblastomaGSE21026 20918913 20920267 1354 0
P300 T30-glioblastomaGSE21026 20934544 20935236 692 0
P300 T30-glioblastomaGSE21026 20985224 20986325 1101 0
RARA MCF7GSE15244 20642573 20643290 717 0
RARA MCF7GSE15244 20765963 20766611 648 0
RARA MCF7GSE15244 20848582 20849485 903 0
RARA MCF7GSE15244 20882085 20882467 382 0
RARA MCF7GSE15244 20985220 20986542 1322 0
RARA MCF7GSE15244 21130081 21131680 1599 0
RARA MCF7GSE15244 21134794 21135643 849 0
RARA MCF7GSE15244 21219357 21220758 1401 0
RARA MCF7GSE15244 21328111 21329069 958 0
RARG MCF7GSE15244 20985185 20986110 925 0
RARG MCF7GSE15244 21219357 21220059 702 0
RNAII Tamoxifen-MCF7GSE14664 20850097 20850187 90 0
Rb GrowingGSE19898 20642534 20642832 298 0
Rb QuiescentGSE19898 20642558 20643059 501 0
Rb SenescentGSE19898 20642465 20643032 567 0
Rb shRbSenescenceGSE19898 20642580 20642873 293 0
STAT1 HeLaGSE12782 20954557 20955521 964 0
STAT1 HeLaGSE12783 20954591 20955446 855 0
STAT1 IFNSISSRdata 20954579 20955397 818 0
Sox2 hESGSE18292 21293956 21294765 809 0
TAF HelaGSE8489 20642505 20643976 1471 0
TAF HelaGSE8489 20895006 20895325 319 0
TAF k562GSE8489 20641605 20643976 2371 0
TAFII hESGSE17917 20642557 20642959 402 0
TFAP2C MCF7GSE21234 20709060 20709458 398 0
TFAP2C MCF7GSE21234 20985391 20986090 699 0
TFAP2C MCF7GSE21234 21219558 21219985 427 0
USF1 HepG2E 20815087 20816110 1023 0
USF2 HepG2E 20815182 20815968 786 0
hScc1 BcellGSE12603 20737719 20738011 292 0
hScc1 BcellGSE12603 21130561 21130829 268 0
hScc1 CdLSGSE12603 20983556 20984327 771 0
hScc1 CdLSGSE12603 21054250 21054618 368 0
hScc1 CdLSGSE12603 21320276 21320666 390 0
hScc1 CdLSGSE12603 21321259 21321991 732 0
p130 QuiescentGSE19898 20642603 20643005 402 0
p130 SenescentGSE19898 20642372 20643044 672 0
p130 SenescentGSE19898 21061047 21061236 189 0
p130 shRbQuiescentGSE19898 20918992 20919689 697 0
p63 keratinocytesGSE17611 20769776 20770454 678 0
p63 keratinocytesGSE17611 20943268 20944201 933 0
p63 keratinocytesGSE17611 21077580 21078384 804 0
p63 keratinocytesGSE17611 21296323 21297536 1213 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
842 Unknown pSILAC let-7b CDKAL1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000145996 n_a n_a n_a "lymphocyte, muscle cell" "malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
22190 mRNA CDKAL1 chr6 20642735 21340611 135 EST chr6 21108330 21136738Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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