Annotation Detail for PPP2R2A

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Basic Information Top

Gene Symbol:	PPP2R2A ( B55A,B55ALPHA,DKFZp686N05117,FLJ26613,FLJ41727,MGC52248,PR52A,PR55A )
Gene Full Name:	protein phosphatase 2, regulatory subunit B, alpha
Band:	8p21.2
Quick Links	Entrez ID:5520; OMIM: 604941; Uniprot ID:2ABA_HUMAN; ENSEMBL ID: ENSG00000221914; HGNC ID: 9304
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
2	N-acetylalanine.

Location(AA)	Modification	Resource
37	N-linked	HMM predict
74	Phosphotyrosine(Syk)	HMM predict
86	Phosphotyrosine(Jak)	HMM predict
143	Phosphotyrosine(EGFR)	HMM predict
192	Phosphotyrosine(Syk)	HMM predict
194	Phosphoserine(CK2)	HMM predict
245	O-linked	HMM predict
277	N-linked	HMM predict
351	N-linked	HMM predict
409	Phosphoserine(CK1)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_002717
Location:chr8 26204950-26284561
strand:+

Upstream the gene:2 results
Downstream the gene:3 results
Inside the gene:15 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3ac	HepG2	E	26203974	26204264	290	832
PHF8	Hs68minusFBS	GSE20725	26204517	26205324	807	30

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	26287489	26287831	342	3099
hScc1	CdLS	GSE12603	26287524	26287866	342	3134
hScc1	G2	GSE9613	26287379	26287901	522	3079

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	26240803	26241284	481	0
ER	MCF7	GSE19013	26221503	26221924	421	0
FOXA1	MCF7	GSE15244	26234378	26234699	321	0
FoxA1	MCF7	MACSdata	26221502	26221734	232	0
FoxA1	MCF7	MACSdata	26243316	26243532	216	0
H3K4me3	colorectal	cancer	26205877	26206449	572	0
H3ac	HepG2	E	26205993	26207579	1586	0
H3ac	HepG2	E	26207905	26208312	407	0
PHF8	HeLa	GSE20725	26204539	26205513	974	0
PolII	HeLa	GSE12783	26204490	26205813	1323	0
hScc1	Bcell	GSE12603	26204716	26205194	478	0
hScc1	Bcell	GSE12603	26240569	26241284	715	0
hScc1	CdLS	GSE12603	26240666	26241322	656	0
p130	Senescent	GSE19898	26243199	26243558	359	0
p130	shRbSenescent	GSE19898	26243212	26243646	434	0

Validated miRNA targets

miR Walk:8 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-136	hsa-mir-136	14	20237410
hsa-miR-136*	hsa-mir-136	14	20237410
hsa-miR-222	hsa-mir-222	X	20103675
hsa-miR-222*	hsa-mir-222	X	20103675
hsa-miR-31	hsa-mir-31	9	20237410
hsa-miR-31*	hsa-mir-31	9	20237410
hsa-miR-376a	hsa-mir-376a-1	0	20237410
hsa-miR-376a	hsa-mir-376a-2	0	20237410

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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