Annotation Detail for LRRC1

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Basic Information Top

Gene Symbol:	LRRC1 ( FLJ10775,FLJ11834,LANO,dJ523E19.1 )
Gene Full Name:	leucine rich repeat containing 1
Band:	6p12.1
Quick Links	Entrez ID:55227; OMIM: 608195; Uniprot ID:LRRC1_HUMAN; ENSEMBL ID: ENSG00000137269; HGNC ID: 14307
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

No data

Location(AA)	Modification	Resource
32	Phosphotyrosine(SRC)	HMM predict
67	Phosphoserine(ATM)	HMM predict
129	N-linked	HMM predict
187	Phosphotyrosine(INSR)	HMM predict
390	N-linked	HMM predict
392	Phosphoserine(ATM)	HMM predict
404	Sulfotyrosine	HMM predict
404	Phosphotyrosine(INSR)	HMM predict
470	N-linked	HMM predict
480	Phosphothreonine(PKA)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_018214
Location:chr6 53767736-53896877
strand:+

Upstream the gene:9 results
Downstream the gene:1 results
Inside the gene:14 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	53766981	53768131	1150	181
ER	E2-MCF7	GSE14664	53752631	53752678	47	15082
H3K4me2	HCT116	GSE10453	53766106	53766549	443	1409
H3K4me3	colorectal	cancer	53766037	53766674	637	1381
H3ac	HepG2	E	53765738	53767277	1539	1229
RARA	MCF7	GSE15244	53766001	53766741	740	1366
Rb	Growing	GSE19898	53766409	53766610	201	1227
hScc1	Bcell	GSE12603	53766981	53768131	1150	181
hScc1	G2	GSE9613	53767018	53768286	1268	85

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	53903338	53903472	134	6528

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	53768719	53769038	319	0
CTCF	G2	GSE9613	53785878	53786041	163	0
FOXA1	MCF7	GSE15244	53842366	53843086	720	0
H3ac	HepG2	E	53768164	53771074	2910	0
H3ac	HepG2	E	53771442	53771681	239	0
H3ac	HepG2	E	53772078	53772455	377	0
Oct1	Hela	GSE14283	53852332	53852363	31	0
Oct1	Hela	GSE14283	53895245	53895285	40	0
RARA	MCF7	GSE15244	53768934	53769451	517	0
RARA	MCF7	GSE15244	53842218	53843122	904	0
RARG	MCF7	GSE15244	53842366	53843049	683	0
RNAII	Tamoxifen-MCF7	GSE14664	53895255	53895297	42	0
TAF	k562	GSE8489	53815343	53816078	735	0
TFAP2C	MCF7	GSE21234	53842553	53843071	518	0

Validated miRNA targets

miR Walk:7 results
Tarbase V5.0:1 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
270	Unknown	MicroArray	miR-124	LRRC1	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000137269		G1-to-S transition	n_a	n_a	n_a	n_a

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
22732	mRNA	LRRC1	chr6	53767253	53896803	137	EST		chr6	53891730	53893545	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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