Annotation Detail for ASXL2

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Basic Information Top

Gene Symbol:	ASXL2 ( ASXH2,DKFZp686C1968,FLJ10898,KIAA1685 )
Gene Full Name:	additional sex combs like 2 (Drosophila)
Band:	2p23.3
Quick Links	Entrez ID:55252; OMIM: 612991; Uniprot ID:ASXL2_HUMAN; ENSEMBL ID: ENSG00000143970; HGNC ID: 23805
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
137	Phosphoserine.
139	Phosphoserine.
142	Phosphoserine.
146	Phosphoserine.
178	Nuclear localization signal (Potential).
224	Phosphoserine.
307	LXXLL motif 1.
517	Phosphoserine.
562	Phosphoserine.
834	Phosphoserine.
845	Phosphoserine.
891	LXXLL motif 2.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	25955224	25955865	641	685
HIF1	Norm	HepG2	25954534	25955289	755	52
Oct1	H2O2-Hela	GSE14283	25960290	25960319	29	5445
Oct1	Hela	GSE14283	25972124	25972178	54	17292
P300	T30-glioblastoma	GSE21026	25962098	25962729	631	7554
USF1	HepG2	E	25955152	25955566	414	500
p130	shRbQuiescent	GSE19898	25954913	25955468	555	331

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	Fulvestrant-MCF7	GSE14664	25811763	25811806	43	3979
Oct1	H2O2-Hela	GSE14283	25796652	25796693	41	19091
Oct1	H2O2-Hela	GSE14283	25811786	25811815	29	3963
Oct1	H2O2-Hela	GSE14283	25811904	25811931	27	3846
Oct1	H2O2-Hela	GSE14283	25812889	25812916	27	2861
Oct1	Hela	GSE14283	25796654	25796693	39	19090
Oct1	Hela	GSE14283	25800343	25800386	43	15399
p63	keratinocytes	GSE17611	25795568	25796715	1147	19622

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	25928277	25928588	311
CTCF	CD4	SISSRdata	25928277	25928588	311
CTCF	G2	GSE9613	25820579	25820836	257
CTCF	G2	GSE9613	25932793	25933024	231
CTCF	G2	GSE9613	25940422	25940705	283
CTCF	G2	GSE9613	25954200	25954606	406
ER	Fulvestrant-MCF7	GSE14664	25889838	25889872	34
ER	MCF7	GSE19013	25885952	25886498	546
ETS1	Jurkat	GSE17954	25953446	25954538	1092
H3K4me3	colorectal	cancer	25954090	25954467	377
H3ac	HepG2	E	25952753	25954667	1914
Myc	hES	GSE17917	25817435	25817657	222
Oct1	H2O2-Hela	GSE14283	25821922	25821950	28
Oct1	H2O2-Hela	GSE14283	25894689	25894718	29
Oct1	Hela	GSE14283	25821918	25821969	51
Oct1	Hela	GSE14283	25830410	25830511	101
Oct1	Hela	GSE14283	25832407	25832441	34
Oct1	Hela	GSE14283	25889839	25889877	38
Oct1	Hela	GSE14283	25894689	25894718	29
Oct1	Hela	GSE14283	25926556	25926583	27
Oct1	Hela	GSE14283	25933728	25933764	36
P300	T30-glioblastoma	GSE21026	25927945	25928950	1005
PHF8	Hs68plusFBS	GSE20725	25953717	25955219	1502
RNAII	Tamoxifen-MCF7	GSE14664	25843457	25843553	96
TAF	Hela	GSE8489	25953486	25954435	949
TAF	k562	GSE8489	25952991	25954435	1444
USF1	HepG2	E	25953486	25954710	1224
USF2	HepG2	E	25953703	25954710	1007
hScc1	Bcell	GSE12603	25954164	25954934	770
p130	Quiescent	GSE19898	25954082	25954910	828
p130	shRbQuiescent	GSE19898	25954396	25954860	464
p130	shRbSenescent	GSE19898	25954249	25955218	969

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-15a	hsa-mir-15a	13	18362358
hsa-miR-15a*	hsa-mir-15a	13	18362358
hsa-miR-16	hsa-mir-16-1	13	18362358
hsa-miR-16	hsa-mir-16-2	3	18362358
hsa-miR-16-1*	hsa-mir-16-1	13	18362358

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
14037	HTC		chr2	25956816	25958595	1779	mRNA	ASXL2	chr2	25873909	26013007	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018