AutismKB 2.0

Annotation Detail for PPP3CA


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Basic Information Top
Gene Symbol:PPP3CA ( CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B )
Gene Full Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Band: 4q24
Quick LinksEntrez ID:5530; OMIM: 114105; Uniprot ID:PP2BA_HUMAN; ENSEMBL ID: ENSG00000138814; HGNC ID: 9314
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
469Phosphoserine (By similarity).
Location(AA) Modifications Resource
469Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
13Phosphothreonine(PKC)HMM predict
107Phosphoserine(CDC2)HMM predict
107Phosphoserine(IKK)HMM predict
224Phosphotyrosine(INSR)HMM predict
224Phosphotyrosine(SRC)HMM predict
296Phosphothreonine(PKC)HMM predict
335N-linkedHMM predict
379Phosphoserine(CK1)HMM predict
419Phosphoserine(CK1)HMM predict
443Phosphothreonine(PKC)HMM predict
508N-linkedHMM predict
513N-linkedHMM predict
516N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000944
  • Location:chr4 102163609-102487375
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 102487772 102488866 1094 944
CTCF G2GSE9613 102490178 102490309 131 2868
Fos K562GSE19551 102487587 102488189 602 513
Myc hESGSE17917 102487548 102487765 217 281
P300 T30-glioblastomaGSE21026 102496253 102497727 1474 9615
PHF8 293TGSE20725 102487850 102488798 948 949
PHF8 HeLaGSE20725 102486474 102488910 2436 317
Rb shRbQuiescentGSE19898 102488597 102488936 339 1391
hScc1 BcellGSE12603 102487772 102488784 1012 903
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 102160256 102160855 599 3054
Rb shRbSenescenceGSE19898 102149980 102150223 243 13508
hScc1 BcellGSE12603 102159420 102159761 341 4019
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 102331335 102332190 855 0
CTCF CD4GSE12889 102309397 102309683 286 0
CTCF CD4SISSRdata 102309397 102309683 286 0
CTCF G2GSE9613 102309234 102309765 531 0
CTCF G2GSE9613 102485716 102487459 1743 0
ER E2-MCF7GSE14664 102225779 102225829 50 0
ER E2-MCF7GSE14664 102230245 102230278 33 0
ER Fulvestrant-MCF7GSE14664 102224527 102224562 35 0
FOXA1 MCF7GSE15244 102404696 102405295 599 0
FOXA1 eGFPGSE10845 102396431 102396977 546 0
FOXA1 eGFPGSE10845 102404696 102405295 599 0
FoxA1 MCF7MACSdata 102396461 102396834 373 0
FoxA1 MCF7MACSdata 102439949 102440114 165 0
NRSF JurkatGSE13047 102472426 102473202 776 0
NRSF mAbJurkat 102470937 102472801 1864 0
NRSF mAbJurkat 102473620 102474293 673 0
NRSF-mono JurkatQuESTdata 102411851 102412096 245 0
NRSF-mono JurkatQuESTdata 102472446 102473162 716 0
NRSF-poly JurkatQuESTdata 102472426 102473212 786 0
Nanog ESGSE20650 102255115 102255611 496 0
Nanog ESGSE20650 102309312 102309796 484 0
Nanog ESGSE20650 102444976 102445492 516 0
Nanog hESGSE18292 102180977 102181391 414 0
Nanog hESGSE18292 102255279 102255599 320 0
Nanog hESGSE18292 102475467 102475702 235 0
Oct1 H2O2-HelaGSE14283 102193503 102193538 35 0
Oct1 H2O2-HelaGSE14283 102288807 102288840 33 0
Oct1 H2O2-HelaGSE14283 102394667 102394700 33 0
Oct1 H2O2-HelaGSE14283 102398727 102398756 29 0
Oct1 H2O2-HelaGSE14283 102466980 102467007 27 0
Oct1 HelaGSE14283 102193503 102193537 34 0
Oct1 HelaGSE14283 102224526 102224569 43 0
Oct1 HelaGSE14283 102228247 102228275 28 0
Oct1 HelaGSE14283 102251065 102251093 28 0
Oct1 HelaGSE14283 102287243 102287287 44 0
Oct1 HelaGSE14283 102288810 102288841 31 0
Oct1 HelaGSE14283 102299527 102299571 44 0
Oct1 HelaGSE14283 102394667 102394699 32 0
Oct1 HelaGSE14283 102398727 102398785 58 0
Oct1 HelaGSE14283 102432400 102432470 70 0
P300 T30-glioblastomaGSE21026 102331249 102332212 963 0
STAT1 IFNSISSRdata 102328008 102328652 644 0
hScc1 BcellGSE12603 102309157 102309810 653 0
hScc1 BcellGSE12603 102485716 102487459 1743 0
hScc1 CdLSGSE12603 102309121 102309922 801 0
hScc1 G2GSE9613 102309157 102309995 838 0
hScc1 G2GSE9613 102485656 102487459 1803 0
p130 SenescentGSE19898 102340817 102341081 264 0
p63 keratinocytesGSE17611 102341308 102342201 893 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-145 hsa-mir-145 5 19915607
hsa-miR-145 hsa-mir-145 5 19915607
hsa-miR-145* hsa-mir-145 5 19915607
hsa-miR-145* hsa-mir-145 5 19915607
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1264 Unknown pSILAC miR-30 PPP3CA down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000138814 n_a n_a n_a "lymphoblast, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20025 mRNA chr4 102438822 102440578 1756 mRNA PPP3CA chr4 102301764 102625531 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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