Annotation Detail for PPP5C

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Basic Information Top

Gene Symbol:	PPP5C ( FLJ36922,PP5,PPP5 )
Gene Full Name:	protein phosphatase 5, catalytic subunit
Band:	19q13.32
Quick Links	Entrez ID:5536; OMIM: 600658; Uniprot ID:PPP5_HUMAN; ENSEMBL ID: ENSG00000011485; HGNC ID: 9322
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
2	N-acetylalanine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ETS1	Jurkat	GSE17954	51541631	51542628	997	4
Rb	Growing	GSE19898	51542013	51542203	190	26
Rb	Quiescent	GSE19898	51541638	51541896	258	367
Rb	Quiescent	GSE19898	51541906	51542159	253	101
Rb	Senescent	GSE19898	51541828	51542129	301	155
TAF	k562	GSE8489	51541437	51541871	434	480
p130	Quiescent	GSE19898	51541928	51542228	300	56
p130	Senescent	GSE19898	51541935	51542102	167	115
p130	shRbQuiescent	GSE19898	51541805	51542063	258	200
p130	shRbSenescent	GSE19898	51541752	51542135	383	190

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	51590742	51591015	273	4936
CTCF	CD4	SISSRdata	51590742	51591015	273	4936
CTCF	Jurkat	GSE12889	51590735	51591037	302	4944
CTCF	G2	GSE9613	51590920	51591141	221	5088
KLF4	hES	GSE17917	51587315	51587613	298	1522
Myc	K562	GSE19551	51590628	51591019	391	4881
P300	T30-glioblastoma	GSE21026	51586884	51588282	1398	1641
hScc1	Bcell	GSE12603	51589034	51589441	407	3295
hScc1	Bcell	GSE12603	51590920	51591285	365	5160
hScc1	CdLS	GSE12603	51590920	51591285	365	5160
hScc1	G2	GSE9613	51590920	51591222	302	5129

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	51542500	51542758	258
CTCF	CD4	SISSRdata	51542500	51542758	258
CTCF	G2	GSE9613	51541908	51542783	875
CTCF	G2	GSE9613	51548935	51549188	253
CTCF	G2	GSE9613	51582808	51583021	213
CTCF	G2	GSE9613	51585069	51585282	213
H3ac	HepG2	E	51543721	51544919	1198
Oct1	H2O2-Hela	GSE14283	51571999	51572028	29
PHF8	293T	GSE20725	51541669	51542788	1119
PHF8	HeLa	GSE20725	51541575	51542746	1171
PHF8	Hs68plusFBS	GSE20725	51541456	51543039	1583
Rb	Growing	GSE19898	51568449	51568618	169
Rb	Senescent	GSE19898	51568570	51568846	276
TFAP2C	MCF7	GSE21234	51567649	51569664	2015
hScc1	Bcell	GSE12603	51578260	51578485	225
hScc1	CdLS	GSE12603	51542115	51542750	635
p130	Senescent	GSE19898	51542187	51542458	271
p130	shRbQuiescent	GSE19898	51566788	51567205	417

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
988	Unknown	pSILAC	miR-155	PPP5C	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000011485		n_a	n_a	n_a	"epithelium, lymphocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
13379	mRNA	PPP5C	chr19	51542133	51585943	148	mRNA		chr19	51585554	51588506	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018