AutismKB 2.0

Annotation Detail for PRIM2


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Basic Information Top
Gene Symbol:PRIM2 ( MGC75142,PRIM2A,p58 )
Gene Full Name: primase, DNA, polypeptide 2 (58kDa)
Band: 6p11.2
Quick LinksEntrez ID:5558; OMIM: 176636; Uniprot ID:PRI2_HUMAN; ENSEMBL ID: ENSG00000146143; HGNC ID: 9370
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
381Phosphotyrosine.
470Phosphothreonine.
Location(AA) Modifications Resource
381Phosphotyrosine.Swiss-Prot 53.0
381PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
19N-linkedHMM predict
21Phosphoserine(PKB)HMM predict
21Phosphoserine(PKA)HMM predict
93Phosphotyrosine(Syk)HMM predict
155Phosphoserine(CK2)HMM predict
172Phosphoserine(CK1)HMM predict
227Phosphoserine(PKG)HMM predict
257SulfotyrosineHMM predict
287S-palmitoylHMM predict
362Phosphotyrosine(INSR)HMM predict
377Phosphoserine(ATM)HMM predict
404Phosphoserine(CDC2)HMM predict
470Phosphothreonine(CDC2)HMM predict
470Phosphothreonine(MAPK)HMM predict
470O-linkedHMM predict
489Phosphoserine(IKK)HMM predict
504Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000947
  • Location:chr6 57290380-57621333
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 57289200 57289531 331 1015
CTCF CD4SISSRdata 57289200 57289531 331 1015
CTCF G2GSE9613 57289277 57289784 507 850
H3ac HepG2E 57289277 57291316 2039 84
LIN9 G0GSE7516 57289716 57290919 1203 63
Nanog hESGSE18292 57289286 57289426 140 1025
PHF8 HeLaGSE20725 57289789 57290874 1085 49
TFAP2C MCF7GSE21234 57289986 57290518 532 129
hScc1 BcellGSE12603 57289277 57289971 694 757
hScc1 CdLSGSE12603 57289277 57289971 694 757
hScc1 G2GSE9613 57289277 57289652 375 916
p130 QuiescentGSE19898 57290084 57290538 454 70
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 57297457 57297625 168 0
CTCF CD4GSE12889 57445603 57445808 205 0
CTCF CD4SISSRdata 57297457 57297625 168 0
CTCF CD4SISSRdata 57445603 57445808 205 0
CTCF G2GSE9613 57295492 57295674 182 0
CTCF G2GSE9613 57504627 57504766 139 0
CTCF G2GSE9613 57520104 57520650 546 0
E2F4 G0GSE7516 57290004 57290812 808 0
ER E2-MCF7GSE14664 57445204 57445282 78 0
FOXA1 MCF7GSE15244 57344445 57345295 850 0
GABP k562GSE8489 57289971 57293248 3277 0
H3K4me2 HCT116GSE10453 57290587 57291192 605 0
H3K4me3 colorectalcancer 57290625 57290986 361 0
H3ac HepG2E 57291876 57292612 736 0
LIN9 SGSE7516 57289971 57291015 1044 0
Oct1 H2O2-HelaGSE14283 57324558 57324586 28 0
Oct1 H2O2-HelaGSE14283 57441888 57441924 36 0
Oct1 H2O2-HelaGSE14283 57459250 57459315 65 0
Oct1 H2O2-HelaGSE14283 57596558 57596584 26 0
Oct1 HelaGSE14283 57348987 57349013 26 0
Oct1 HelaGSE14283 57427548 57427596 48 0
Oct1 HelaGSE14283 57432410 57432478 68 0
Oct1 HelaGSE14283 57441886 57441924 38 0
Oct1 HelaGSE14283 57486254 57486286 32 0
Oct1 HelaGSE14283 57488874 57488951 77 0
Oct1 HelaGSE14283 57507776 57507803 27 0
Oct1 HelaGSE14283 57534305 57534338 33 0
Oct1 HelaGSE14283 57596543 57596595 52 0
RARA MCF7GSE15244 57344626 57345015 389 0
Rb QuiescentGSE19898 57290173 57290668 495 0
Rb SenescentGSE19898 57290134 57290747 613 0
TAF k562GSE8489 57290444 57292430 1986 0
hScc1 G2GSE9613 57553530 57553668 138 0
p130 QuiescentGSE19898 57362712 57362919 207 0
p130 SenescentGSE19898 57290061 57290730 669 0
p130 shRbQuiescentGSE19898 57290001 57290772 771 0
p130 shRbSenescentGSE19898 57290143 57290847 704 0
p130 G0GSE7516 57290076 57290919 843 0
p130 SGSE7516 57290179 57290883 704 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018