AutismKB 2.0

Annotation Detail for PRKAA1


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Basic Information Top
Gene Symbol:PRKAA1 ( AMPK,AMPKa1,MGC33776,MGC57364 )
Gene Full Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Band: 5p13.1
Quick LinksEntrez ID:5562; OMIM: 602739; Uniprot ID:AAPK1_HUMAN; ENSEMBL ID: ENSG00000132356; HGNC ID: 9376
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
32Phosphothreonine.
183Phosphothreonine; by STK11 (By
184Phosphoserine.
187Phosphoserine.
269Phosphothreonine (By similarity).
355Phosphothreonine.
356Phosphoserine.
382Phosphothreonine.
397Phosphoserine.
441Phosphotyrosine.
442Phosphotyrosine.
467Phosphoserine.
476Phosphoserine.
486Phosphoserine.
488Phosphothreonine.
490Phosphothreonine.
496Phosphoserine.
502Phosphoserine.
506Phosphoserine.
508Phosphoserine.
516Phosphoserine.
520Phosphoserine.
522Phosphothreonine.
523Phosphoserine.
524Phosphoserine.
527Phosphoserine.
Location(AA) Modifications Resource
174Phosphothreonine (by STK11) (Bysimilarity).Swiss-Prot 53.0
174Phosphothreonine (AMPK
175Phosphoserine (By similarity).Swiss-Prot 53.0
487PhosphoserinePhospho.ELM 6.0
499Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
106Phosphotyrosine(INSR)HMM predict
106Phosphotyrosine(EGFR)HMM predict
174PhosphothreonineHMM predict
181Phosphotyrosine(Abl)HMM predict
181Phosphotyrosine(INSR)HMM predict
192Phosphotyrosine(INSR)HMM predict
192Phosphotyrosine(Abl)HMM predict
240N-linkedHMM predict
343Phosphotyrosine(Jak)HMM predict
343Phosphotyrosine(Syk)HMM predict
351Phosphoserine(CK2)HMM predict
373Phosphothreonine(MAPK)HMM predict
379Phosphothreonine(PKC)HMM predict
467Phosphoserine(CK2)HMM predict
479O-linkedHMM predict
479O-linkedHMM predict
481Phosphothreonine(CDC2)HMM predict
481Phosphothreonine(MAPK)HMM predict
481Phosphothreonine(CDK)HMM predict
487Phosphoserine(PKC)HMM predict
487Phosphoserine(CK1)HMM predict
487Phosphoserine(PKA)HMM predict
499PhosphoserineHMM predict
499Phosphoserine(CK2)HMM predict
511Phosphoserine(CK1)HMM predict
511O-linkedHMM predict
511Phosphoserine(IKK)HMM predict
513O-linkedHMM predict
515Phosphoserine(IKK)HMM predict
517O-linkedHMM predict
518O-linkedHMM predict
518Phosphoserine(CK1)HMM predict
527O-linkedHMM predict
527Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006251
  • Location:chr5 40795238-40834053
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 40845455 40845492 37 11420
Oct1 HelaGSE14283 40845453 40845491 38 11419
PHF8 293TGSE20725 40833414 40834701 1287 4
p130 SenescentGSE19898 40834233 40834702 469 414
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 40833367 40834463 1096 0
FOXA1 MCF7GSE15244 40811147 40812103 956 0
H3K4me3 colorectalcancer 40832800 40833551 751 0
Oct1 H2O2-HelaGSE14283 40828544 40828571 27 0
Oct1 HelaGSE14283 40828537 40828570 33 0
PHF8 HeLaGSE20725 40832962 40834892 1930 0
PHF8 Hs68plusFBSGSE20725 40833328 40834772 1444 0
TAF HelaGSE8489 40832259 40833517 1258 0
hScc1 BcellGSE12603 40833403 40834463 1060 0
p130 shRbSenescentGSE19898 40833830 40834020 190 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 16459310
hsa-miR-122* hsa-mir-122 18 16459310
hsa-miR-451 hsa-mir-451 17 20647762
hsa-miR-451 hsa-mir-451 17 20227367
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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