Annotation Detail for PRKACA

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Basic Information Top

Gene Symbol:	PRKACA ( MGC102831,MGC48865,PKACA )
Gene Full Name:	protein kinase, cAMP-dependent, catalytic, alpha
Band:	19p13.1
Quick Links	Entrez ID:5566; OMIM: 601639; Uniprot ID:KAPCA_HUMAN; ENSEMBL ID: ENSG00000072062; HGNC ID: 9380
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:8 results
Experimental PTM Sites from dbPTM:9 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
3	Deamidated asparagine (By similarity).
11	Phosphoserine; by autocatalysis (By
49	Phosphothreonine.
140	Phosphoserine (By similarity).
196	Phosphothreonine.
198	Phosphothreonine.
202	Phosphothreonine.
339	Phosphoserine.

Location(AA)	Modifications	Resource
2	N-myristoyl glycine (By similarity).	Swiss-Prot 53.0
3	Deamidated asparagine (By similarity).	Swiss-Prot 53.0
11	Phosphoserine; by autocatalysis (Bysimilarity).	Swiss-Prot 53.0
140	Phosphoserine (By similarity).	Swiss-Prot 53.0
196	Phosphothreonine (By similarity).	Swiss-Prot 53.0
198	Phosphothreonine.	Swiss-Prot 53.0
202	Phosphothreonine.	Swiss-Prot 53.0
338	Phosphoserine	Phospho.ELM 6.0
339	Phosphoserine.	Swiss-Prot 53.0

Location(AA)	Modification	Resource
118	Phosphotyrosine(SRC)	HMM predict
118	Phosphotyrosine(INSR)	HMM predict
118	Phosphotyrosine(Abl)	HMM predict
180	Phosphotyrosine(Syk)	HMM predict
180	Phosphotyrosine(EGFR)	HMM predict
331	Phosphotyrosine(Syk)	HMM predict
331	Sulfotyrosine	HMM predict
331	Phosphotyrosine(INSR)	HMM predict
331	Phosphotyrosine(EGFR)	HMM predict
345	Glycine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_002730
Location:chr19 14063508-14089558
strand:-

Upstream the gene:5 results
Downstream the gene:0 results
Inside the gene:2 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	14089329	14090425	1096	319
Rb	Senescent	GSE19898	14089457	14089950	493	145
Rb	shRbSenescence	GSE19898	14089549	14089779	230	106
p130	Senescent	GSE19898	14089492	14089922	430	149
p130	shRbSenescent	GSE19898	14089502	14089788	286	87

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	14086399	14086895	496	0
hScc1	Bcell	GSE12603	14089282	14089822	540	0

Validated miRNA targets

miR Walk:5 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	19229884
hsa-miR-1	hsa-mir-1-1	20	19229884
hsa-miR-142-3p	hsa-mir-142	17	19229884
hsa-miR-331-3p	hsa-mir-331	12	19229884
hsa-miR-331-5p	hsa-mir-331	12	19229884

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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