AutismKB 2.0

Annotation Detail for PRKCA


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Basic Information Top
Gene Symbol:PRKCA ( AAG6,MGC129900,MGC129901,PKC-alpha,PKCA,PRKACA )
Gene Full Name: protein kinase C, alpha
Band: 17q24.2
Quick LinksEntrez ID:5578; OMIM: 176960; Uniprot ID:KPCA_HUMAN; ENSEMBL ID: ENSG00000154229; HGNC ID: 9393
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
195Phosphotyrosine.
208Phosphoserine.
226Phosphoserine.
319Phosphoserine.
494Phosphothreonine (By similarity).
495Phosphothreonine (By similarity).
497Phosphothreonine.
501Phosphothreonine.
604N6-acetyllysine.
628N6-acetyllysine.
631Phosphothreonine; by autocatalysis
638Phosphothreonine; by autocatalysis.
657Phosphoserine (By similarity).
658Phosphotyrosine.
Location(AA) Modifications Resource
225PhosphoserinePhospho.ELM 6.0
226Phosphoserine.Swiss-Prot 53.0
318PhosphoserinePhospho.ELM 6.0
319Phosphoserine.Swiss-Prot 53.0
494Phosphothreonine (By similarity).Swiss-Prot 53.0
495Phosphothreonine (By similarity).Swiss-Prot 53.0
497Phosphothreonine.Swiss-Prot 53.0
501Phosphothreonine.Swiss-Prot 53.0
631Phosphothreonine (by autocatalysis)(Potential).Swiss-Prot 53.0
637PhosphothreoninePhospho.ELM 6.0
638Phosphothreonine (by autocatalysis).Swiss-Prot 53.0
656Phosphoserine (PKC alpha)Phospho.ELM 6.0
657Phosphoserine (By similarity).Swiss-Prot 53.0
657Phosphotyrosine (Syk)Phospho.ELM 6.0
658Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
8N-linkedHMM predict
13Phosphoserine(ATM)HMM predict
70S-palmitoylHMM predict
71S-palmitoylHMM predict
163Phosphotyrosine(EGFR)HMM predict
195Phosphotyrosine(Jak)HMM predict
206N-linkedHMM predict
241Phosphoserine(CK1)HMM predict
285Phosphotyrosine(SRC)HMM predict
285Phosphotyrosine(Jak)HMM predict
285Phosphotyrosine(Syk)HMM predict
286SulfotyrosineHMM predict
504Phosphotyrosine(INSR)HMM predict
554N-linkedHMM predict
562Phosphoserine(CK1)HMM predict
658Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002737
  • Location:chr17 61729387-62237323
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 61728012 61728494 482 1135
H3ac HepG2E 61728232 61728617 385 963
KLF4 hESGSE17917 61728743 61729021 278 506
Myc K562GSE19551 61722862 61723221 359 6346
RARA MCF7GSE15244 61722836 61723117 281 6411
TFAP2C MCF7GSE21234 61722793 61723280 487 6351
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 62238553 62238970 417 1438
NRSF JurkatGSE13047 62255667 62257230 1563 19125
NRSF mAbJurkat 62255404 62259011 3607 19884
NRSF-mono JurkatQuESTdata 62255723 62256957 1234 19017
NRSF-poly JurkatQuESTdata 62255786 62257369 1583 19254
Rb QuiescentGSE19898 62256277 62256530 253 19080
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 61875859 61879910 4051 0
CBP JurkatGSE17954 61950679 61954280 3601 0
CTCF CD4GSE12889 61853004 61853291 287 0
CTCF CD4GSE12889 61993813 61994111 298 0
CTCF CD4GSE12889 62154608 62154787 179 0
CTCF CD4SISSRdata 61853004 61853291 287 0
CTCF CD4SISSRdata 61993813 61994111 298 0
CTCF CD4SISSRdata 62154608 62154787 179 0
CTCF G2GSE9613 61729140 61730008 868 0
CTCF G2GSE9613 61852450 61853297 847 0
CTCF G2GSE9613 61993741 61994220 479 0
CTCF G2GSE9613 62100354 62100810 456 0
CTCF G2GSE9613 62142250 62142815 565 0
CTCF G2GSE9613 62154277 62155067 790 0
CTCF G2GSE9613 62211211 62211497 286 0
ER E2-MCF7GSE14664 61933682 61933714 32 0
ER E2-MCF7GSE14664 61941184 61941219 35 0
ER E2-MCF7GSE14664 61969733 61969786 53 0
ER E2-MCF7GSE14664 61972082 61972114 32 0
ER E2-MCF7GSE14664 61979414 61979447 33 0
ER Fulvestrant-MCF7GSE14664 61893908 61893953 45 0
ER Fulvestrant-MCF7GSE14664 61896304 61896396 92 0
FOXA1 MCF7GSE15244 61929543 61930161 618 0
FOXA1 MCF7GSE15244 62102013 62103496 1483 0
FOXA1 MCF7GSE15244 62138360 62138846 486 0
Fos K562GSE19551 61775045 61775705 660 0
Fos K562GSE19551 61920532 61921021 489 0
Fos K562GSE19551 62087608 62088441 833 0
FoxA1 MCF7MACSdata 61889449 61889842 393 0
FoxA1 MCF7MACSdata 61929475 61929772 297 0
FoxA1 MCF7MACSdata 61973999 61974389 390 0
FoxA1 MCF7MACSdata 62102959 62103456 497 0
FoxA1 MCF7MACSdata 62129151 62129465 314 0
FoxA1 MCF7MACSdata 62138550 62138820 270 0
Gata2 K562GSE18868 61894725 61895323 598 0
H3K4me3 colorectalcancer 61730594 61730812 218 0
H3ac HepG2E 61730631 61731998 1367 0
Myc K562GSE19551 61889476 61889951 475 0
Myc K562GSE19551 61968387 61968729 342 0
Myc K562GSE19551 61993795 61994071 276 0
Nanog hESGSE18292 61876410 61877009 599 0
Nanog hESGSE18292 62191088 62191359 271 0
Oct1 H2O2-HelaGSE14283 61759047 61759075 28 0
Oct1 H2O2-HelaGSE14283 61765469 61765497 28 0
Oct1 H2O2-HelaGSE14283 61841634 61841666 32 0
Oct1 H2O2-HelaGSE14283 61860552 61860579 27 0
Oct1 H2O2-HelaGSE14283 61869914 61869945 31 0
Oct1 H2O2-HelaGSE14283 61893744 61893773 29 0
Oct1 H2O2-HelaGSE14283 61893881 61893945 64 0
Oct1 H2O2-HelaGSE14283 62150338 62150375 37 0
Oct1 H2O2-HelaGSE14283 62199443 62199482 39 0
Oct1 H2O2-HelaGSE14283 62218815 62218842 27 0
Oct1 H2O2-HelaGSE14283 62224218 62224255 37 0
Oct1 HelaGSE14283 61735717 61735748 31 0
Oct1 HelaGSE14283 61834564 61834595 31 0
Oct1 HelaGSE14283 61841634 61841666 32 0
Oct1 HelaGSE14283 61893695 61893781 86 0
Oct1 HelaGSE14283 61893869 61893970 101 0
Oct1 HelaGSE14283 61943724 61943753 29 0
Oct1 HelaGSE14283 62025162 62025199 37 0
Oct1 HelaGSE14283 62096265 62096297 32 0
Oct1 HelaGSE14283 62150337 62150377 40 0
Oct1 HelaGSE14283 62161246 62161285 39 0
Oct1 HelaGSE14283 62199443 62199481 38 0
Oct1 HelaGSE14283 62224203 62224254 51 0
Oct1 HelaGSE14283 62225480 62225515 35 0
Oct4 hESGSE17917 61900785 61901184 399 0
Oct4 hESGSE21916 61900747 61901339 592 0
P300 T30-glioblastomaGSE21026 61892298 61894377 2079 0
PAX3-FKHR Rh4GSE19063 61750937 61751922 985 0
PAX3-FKHR Rh4GSE19063 62039177 62040213 1036 0
PHF8 Hs68minusFBSGSE20725 62142843 62143777 934 0
RARA MCF7GSE15244 61775108 61775746 638 0
RARA MCF7GSE15244 61779492 61779990 498 0
RARA MCF7GSE15244 61780317 61780689 372 0
RARA MCF7GSE15244 61813398 61814010 612 0
RARA MCF7GSE15244 61878285 61879190 905 0
RARA MCF7GSE15244 61929543 61930233 690 0
RARA MCF7GSE15244 61943234 61943411 177 0
RARA MCF7GSE15244 61993770 61994584 814 0
RARA MCF7GSE15244 62088003 62089011 1008 0
RARA MCF7GSE15244 62100170 62101143 973 0
RARA MCF7GSE15244 62102013 62103566 1553 0
RARA MCF7GSE15244 62107018 62107487 469 0
RARA MCF7GSE15244 62144198 62144492 294 0
RARA MCF7GSE15244 62182063 62182237 174 0
RARG MCF7GSE15244 61780317 61780689 372 0
RARG MCF7GSE15244 61852247 61853154 907 0
RARG MCF7GSE15244 61929543 61930161 618 0
RARG MCF7GSE15244 61994057 61994512 455 0
RARG MCF7GSE15244 62008538 62008818 280 0
RARG MCF7GSE15244 62088234 62089090 856 0
RARG MCF7GSE15244 62102013 62103533 1520 0
RARG MCF7GSE15244 62107279 62107487 208 0
RARG MCF7GSE15244 62142286 62143576 1290 0
RARG MCF7GSE15244 62144198 62144650 452 0
RARG MCF7GSE15244 62152629 62152937 308 0
RARG MCF7GSE15244 62154277 62154817 540 0
RARG MCF7GSE15244 62181320 62182237 917 0
RUNX JurkatGSE17954 62225720 62225853 133 0
RUNX JurkatGSE17954 62225877 62226007 130 0
Rb QuiescentGSE19898 61967214 61967393 179 0
Rb QuiescentGSE19898 61969103 61969228 125 0
Rb SenescentGSE19898 61729366 61729629 263 0
Rb shRbQuiescentGSE19898 61853107 61853232 125 0
STAT1 HeLaGSE12782 61929048 61930544 1496 0
STAT1 HeLaGSE12782 62156331 62157823 1492 0
STAT1 HeLaGSE12782 62160216 62161792 1576 0
STAT1 HeLaGSE12783 61929082 61930510 1428 0
STAT1 HeLaGSE12783 61933135 61936844 3709 0
STAT1 HeLaGSE12783 62156331 62157789 1458 0
STAT1 HeLaGSE12783 62160250 62161729 1479 0
STAT1 IFNSISSRdata 61929417 61930411 994 0
Sox2 hESGSE18292 62191031 62191318 287 0
TAF k562GSE8489 61736330 61736836 506 0
TAF k562GSE8489 61781501 61782149 648 0
TFAP2C MCF7GSE21234 61843839 61844440 601 0
TFAP2C MCF7GSE21234 61889265 61889908 643 0
TFAP2C MCF7GSE21234 62100306 62101061 755 0
TFAP2C MCF7GSE21234 62102849 62103657 808 0
TFAP2C MCF7GSE21234 62144029 62144792 763 0
USF1 HepG2E 62203796 62204784 988 0
USF2 HepG2E 61841979 61842551 572 0
USF2 HepG2E 62203796 62204452 656 0
hScc1 BcellGSE12603 61729140 61729814 674 0
hScc1 BcellGSE12603 61847803 61847978 175 0
hScc1 BcellGSE12603 61931417 61931740 323 0
hScc1 BcellGSE12603 61993770 61994179 409 0
hScc1 BcellGSE12603 62100389 62100810 421 0
hScc1 BcellGSE12603 62142177 62142956 779 0
hScc1 BcellGSE12603 62154343 62154993 650 0
hScc1 CdLSGSE12603 61729140 61729949 809 0
hScc1 CdLSGSE12603 61783652 61783796 144 0
hScc1 CdLSGSE12603 61993620 61994293 673 0
hScc1 CdLSGSE12603 62100354 62100810 456 0
hScc1 CdLSGSE12603 62142074 62143144 1070 0
hScc1 CdLSGSE12603 62154415 62154918 503 0
hScc1 G2GSE9613 61993662 61994380 718 0
hScc1 G2GSE9613 62100074 62100810 736 0
hScc1 G2GSE9613 62142250 62142740 490 0
p130 QuiescentGSE19898 61967134 61967360 226 0
p130 SenescentGSE19898 61966744 61967494 750 0
p130 SenescentGSE19898 62082220 62082484 264 0
p130 shRbQuiescentGSE19898 61858416 61859089 673 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-101 hsa-mir-101-1 1 20444294
hsa-miR-101 hsa-mir-101-2 9 20444294
hsa-miR-101 hsa-mir-101-1 1 20444294
hsa-miR-101 hsa-mir-101-2 9 20444294
hsa-miR-150 hsa-mir-150 19 19117988
hsa-miR-150 hsa-mir-150 19 19117988
hsa-miR-150* hsa-mir-150 19 19117988
hsa-miR-150* hsa-mir-150 19 19117988
hsa-miR-15a hsa-mir-15a 13 19117988
hsa-miR-15a hsa-mir-15a 13 19117988
hsa-miR-15a* hsa-mir-15a 13 19117988
hsa-miR-15a* hsa-mir-15a 13 19117988
hsa-miR-29c hsa-mir-29c 1 20444294
hsa-miR-29c hsa-mir-29c 1 20444294
hsa-miR-29c* hsa-mir-29c 1 20444294
hsa-miR-29c* hsa-mir-29c 1 20444294
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11553 mRNA PRKCA chr17 61729387 62237324 18784 mRNA chr17 61824650 61843434 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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