AutismKB 2.0

Annotation Detail for FGD6


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Basic Information Top
Gene Symbol:FGD6 ( ZFYVE24 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 6
Band: 12q22
Quick LinksEntrez ID:55785; OMIM: 613520; Uniprot ID:FGD6_HUMAN; ENSEMBL ID: ENSG00000180263; HGNC ID: 21740
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
515Phosphoserine.
721Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
62Phosphoserine(CDC2)HMM predict
70Phosphoserine(CDK)HMM predict
70Phosphoserine(CDC2)HMM predict
100N-linkedHMM predict
103N-linkedHMM predict
105Phosphotyrosine(INSR)HMM predict
203Phosphothreonine(PKA)HMM predict
226Phosphoserine(ATM)HMM predict
226Phosphoserine(CDK)HMM predict
226PhosphoserineHMM predict
228Phosphoserine(CDC2)HMM predict
228Phosphoserine(MAPK)HMM predict
228Phosphoserine(ATM)HMM predict
231Phosphoserine(CDK)HMM predict
282Phosphothreonine(PKC)HMM predict
282Phosphothreonine(PKA)HMM predict
314Phosphothreonine(CDC2)HMM predict
314Phosphothreonine(MAPK)HMM predict
333Phosphothreonine(MAPK)HMM predict
333Phosphothreonine(CDK)HMM predict
335Phosphoserine(CK2)HMM predict
347O-linkedHMM predict
348Phosphoserine(IKK)HMM predict
406N-linkedHMM predict
422Phosphoserine(IKK)HMM predict
423N-linkedHMM predict
425Phosphoserine(CK1)HMM predict
426Phosphoserine(CK1)HMM predict
503Phosphoserine(IKK)HMM predict
524Phosphotyrosine(EGFR)HMM predict
526PhosphoserineHMM predict
531Phosphoserine(CK1)HMM predict
532Phosphoserine(CK1)HMM predict
535Phosphoserine(CK1)HMM predict
562PhosphoserineHMM predict
592Phosphoserine(CK1)HMM predict
595O-linkedHMM predict
595O-linkedHMM predict
605Phosphoserine(IKK)HMM predict
605Phosphoserine(PKB)HMM predict
605Phosphoserine(PKG)HMM predict
618S-palmitoylHMM predict
663Phosphoserine(CK2)HMM predict
696Phosphotyrosine(INSR)HMM predict
696SulfotyrosineHMM predict
697Phosphoserine(CK1)HMM predict
707Phosphoserine(PKA)HMM predict
707Phosphoserine(PKG)HMM predict
712O-linkedHMM predict
731Phosphoserine(CK1)HMM predict
732Phosphoserine(CK1)HMM predict
733Phosphoserine(ATM)HMM predict
737Phosphotyrosine(Syk)HMM predict
741O-linkedHMM predict
779N-linkedHMM predict
791Phosphotyrosine(Syk)HMM predict
797Phosphotyrosine(SRC)HMM predict
797Phosphotyrosine(Syk)HMM predict
815Phosphoserine(CK1)HMM predict
818Phosphoserine(IKK)HMM predict
818Phosphoserine(ATM)HMM predict
818Phosphoserine(CK2)HMM predict
839N-linkedHMM predict
841Phosphoserine(CK2)HMM predict
847Phosphoserine(CK2)HMM predict
847Phosphoserine(CK1)HMM predict
847Phosphoserine(IKK)HMM predict
848Phosphoserine(CK1)HMM predict
850Phosphoserine(CK1)HMM predict
850Phosphoserine(CK2)HMM predict
851Phosphoserine(CK1)HMM predict
881Phosphoserine(CK1)HMM predict
924Phosphotyrosine(Jak)HMM predict
962Phosphotyrosine(Jak)HMM predict
962Phosphotyrosine(INSR)HMM predict
1040SulfotyrosineHMM predict
1058N-linkedHMM predict
1100Phosphoserine(PKG)HMM predict
1144Phosphothreonine(PKA)HMM predict
1144Phosphothreonine(PKC)HMM predict
1169Phosphothreonine(PKC)HMM predict
1264Phosphotyrosine(INSR)HMM predict
1302Phosphoserine(IKK)HMM predict
1305Phosphoserine(CK1)HMM predict
1310Phosphoserine(IKK)HMM predict
1337Phosphoserine(CK1)HMM predict
1392Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_018351
  • Location:chr12 93998947-94135370
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 94134979 94136133 1154 186
CTCF G2GSE9613 94136766 94137093 327 1559
ETS1 JurkatGSE17954 94134803 94136180 1377 121
Fos K562GSE19551 94135205 94135976 771 220
H3K4me3 colorectalcancer 94136492 94137093 601 1422
H3ac HepG2E 94136625 94137093 468 1489
P300 T30-glioblastomaGSE21026 94134408 94136344 1936 6
PHF8 HeLaGSE20725 94134723 94136447 1724 215
PHF8 Hs68plusFBSGSE20725 94134683 94136510 1827 226
RARG MCF7GSE15244 94135990 94136944 954 1097
hScc1 BcellGSE12603 94134788 94136133 1345 90
hScc1 G2GSE9613 94134904 94136350 1446 257
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 93995218 93995482 264 3598
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 94020986 94021744 758 0
CTCF CD4GSE12889 94035005 94035336 331 0
CTCF CD4SISSRdata 94035005 94035336 331 0
CTCF G2GSE9613 94034739 94035301 562 0
CTCF G2GSE9613 94044068 94044298 230 0
ER Breast-CancerGSE22609 94016099 94016660 561 0
ER MCF7GSE19013 94016200 94016858 658 0
ER MCF7GSE19013 94090275 94090871 596 0
FOXA1 DLD1GSE12801 94003477 94004409 932 0
FOXA1 DLD1GSE12801 94014759 94015230 471 0
FOXA1 DLD1GSE12801 94016200 94016736 536 0
FOXA1 DLD1GSE12801 94021176 94021395 219 0
FOXA1 MCF7GSE15244 94021176 94021395 219 0
Fos K562GSE19551 94087142 94087600 458 0
Fos K562GSE19551 94100646 94101309 663 0
H3K4me3 colorectalcancer 94134224 94134904 680 0
H3ac HepG2E 94133869 94135084 1215 0
KLF4 hESGSE17917 94046609 94047054 445 0
Myc K562GSE19551 94122134 94122822 688 0
Nanog hESGSE18292 94032658 94033190 532 0
Oct1 HelaGSE14283 94108105 94108133 28 0
P300 T30-glioblastomaGSE21026 94020762 94021734 972 0
RARA MCF7GSE15244 94021176 94021395 219 0
RARA MCF7GSE15244 94091100 94092213 1113 0
RARA MCF7GSE15244 94134462 94134904 442 0
RARG MCF7GSE15244 94020415 94020659 244 0
RARG MCF7GSE15244 94021176 94021395 219 0
RARG MCF7GSE15244 94091064 94092454 1390 0
STAT1 HeLaGSE12783 94117920 94119985 2065 0
Sox2 hESGSE18292 94032691 94033179 488 0
TAF HelaGSE8489 94121329 94122328 999 0
TAF HelaGSE8489 94133944 94135189 1245 0
hScc1 BcellGSE12603 94034925 94035301 376 0
hScc1 CdLSGSE12603 94021176 94021395 219 0
hScc1 CdLSGSE12603 94034996 94035301 305 0
hScc1 CdLSGSE12603 94134788 94135884 1096 0
hScc1 G2GSE9613 94034608 94035301 693 0
hScc1 G2GSE9613 94044068 94044298 230 0
p130 QuiescentGSE19898 94036511 94036731 220 0
p130 SenescentGSE19898 94122123 94122397 274 0
p63 keratinocytesGSE17611 94069175 94070304 1129 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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