AutismKB 2.0

Annotation Detail for AXL


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Basic Information Top
Gene Symbol:AXL ( JTK11,UFO )
Gene Full Name: AXL receptor tyrosine kinase
Band: 19q13.2
Quick LinksEntrez ID:558; OMIM: 109135; Uniprot ID:UFO_HUMAN; ENSEMBL ID: ENSG00000167601; HGNC ID: 905
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
43N-linked (GlcNAc...) (Potential).
100Phosphoserine.
157N-linked (GlcNAc...) (Potential).
198N-linked (GlcNAc...) (Potential).
339N-linked (GlcNAc...) (Potential).
345N-linked (GlcNAc...) (Potential).
401N-linked (GlcNAc...) (Potential).
702Phosphotyrosine.
703Phosphotyrosine; by autocatalysis (By
866Phosphotyrosine.
875Phosphoserine.
884Phosphoserine.
Location(AA) Modifications Resource
36N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
150N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
191N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
332N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
338N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
394N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
696Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
772Phosphotyrosine (Axl)Phospho.ELM 6.0
814Phosphotyrosine (Axl)Phospho.ELM 6.0
859Phosphotyrosine (Axl)Phospho.ELM 6.0
Location(AA) Modification Resource
36N-linkedHMM predict
103Phosphoserine(CK1)HMM predict
125Phosphotyrosine(INSR)HMM predict
147Phosphothreonine(MAPK)HMM predict
191N-linkedHMM predict
278O-linkedHMM predict
278O-linkedHMM predict
281O-linkedHMM predict
305O-linkedHMM predict
307Phosphoserine(ATM)HMM predict
332N-linkedHMM predict
338N-linkedHMM predict
340Phosphoserine(CAMK2)HMM predict
394N-linkedHMM predict
472Phosphothreonine(PKA)HMM predict
474Phosphotyrosine(EGFR)HMM predict
495MethyllysineHMM predict
502Phosphothreonine(PKA)HMM predict
605Phosphoserine(IKK)HMM predict
655Phosphotyrosine(Jak)HMM predict
658Phosphothreonine(PKC)HMM predict
695PhosphotyrosineHMM predict
731O-linkedHMM predict
741Phosphothreonine(MAPK)HMM predict
752SulfotyrosineHMM predict
772Phosphotyrosine(INSR)HMM predict
814Phosphotyrosine(INSR)HMM predict
814SulfotyrosineHMM predict
823Phosphotyrosine(Abl)HMM predict
823Phosphotyrosine(EGFR)HMM predict
868O-linkedHMM predict
868Phosphoserine(CDC2)HMM predict
868PhosphoserineHMM predict
868Phosphoserine(CDK)HMM predict
868Phosphoserine(IKK)HMM predict
877O-linkedHMM predict
877Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001699
  • Location:chr19 46416662-46459509
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 46416246 46416471 225 304
TFAP2C MCF7GSE21234 46415369 46415823 454 1067
p63 keratinocytesGSE17611 46415726 46417170 1444 215
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me2 HCT116GSE10453 46459543 46460012 469 268
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 46430345 46430425 80 0
ER E2-MCF7GSE14664 46450050 46450090 40 0
ER Fulvestrant-MCF7GSE14664 46427389 46427425 36 0
Oct1 H2O2-HelaGSE14283 46419429 46419457 28 0
Oct1 H2O2-HelaGSE14283 46427398 46427423 25 0
Oct1 H2O2-HelaGSE14283 46432789 46432816 27 0
Oct1 HelaGSE14283 46419404 46419457 53 0
Oct1 HelaGSE14283 46427394 46427431 37 0
Oct1 HelaGSE14283 46429744 46429786 42 0
Oct1 HelaGSE14283 46454509 46454567 58 0
SRF GMOGSE8489 46422441 46422711 270 0
TAF k562GSE8489 46423145 46423473 328 0
p130 shRbQuiescentGSE19898 46423134 46423963 829 0
p130 shRbSenescentGSE19898 46423317 46424054 737 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
152 Unknown MicroArray miR-1 AXL n_a 15685193
1138 Unknown pSILAC miR-1 AXL down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000167601 "cardiac and skeletal muscles, cardiogenesis" n_a n_a "squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000167601 n_a n_a n_a "squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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