AutismKB 2.0

Annotation Detail for PRKCE


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Basic Information Top
Gene Symbol:PRKCE ( MGC125656,MGC125657,PKCE,nPKC-epsilon )
Gene Full Name: protein kinase C, epsilon
Band: 2p21
Quick LinksEntrez ID:5581; OMIM: 176975; Uniprot ID:KPCE_HUMAN; ENSEMBL ID: ENSG00000171132; HGNC ID: 9401
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
228Phosphothreonine.
309Phosphothreonine.
316Phosphoserine.
329Phosphoserine.
337Phosphoserine (By similarity).
339Phosphoserine.
346Phosphoserine.
349Phosphothreonine (By similarity).
350Phosphoserine.
368Phosphoserine.
566Phosphothreonine; by PDPK1.
703Phosphothreonine; by autocatalysis
710Phosphothreonine; by autocatalysis
729Phosphoserine; by autocatalysis.
Location(AA) Modifications Resource
337Phosphoserine (By similarity).Swiss-Prot 53.0
349Phosphothreonine (By similarity).Swiss-Prot 53.0
566Phosphothreonine (by PDPK1).Swiss-Prot 53.0
566Phosphothreonine (PDK-1)Phospho.ELM 6.0
703Phosphothreonine (by autocatalysis)(Potential).Swiss-Prot 53.0
710Phosphothreonine (by autocatalysis)(Potential).Swiss-Prot 53.0
710PhosphothreoninePhospho.ELM 6.0
729Phosphoserine (by autocatalysis).Swiss-Prot 53.0
729Phosphoserine (PKC epsilon)Phospho.ELM 6.0
Location(AA) Modification Resource
97N-linkedHMM predict
108N-linkedHMM predict
199Phosphotyrosine(EGFR)HMM predict
261Phosphoserine(CK1)HMM predict
329Phosphoserine(CDC2)HMM predict
334Phosphoserine(IKK)HMM predict
337Phosphoserine(CDC2)HMM predict
344Phosphoserine(CK1)HMM predict
344Phosphoserine(IKK)HMM predict
346Phosphoserine(PKA)HMM predict
346O-linkedHMM predict
346Phosphoserine(IKK)HMM predict
350Phosphoserine(IKK)HMM predict
380Phosphoserine(PKB)HMM predict
381Phosphoserine(IKK)HMM predict
381Phosphoserine(CDK)HMM predict
381Phosphoserine(CDC2)HMM predict
566O-linkedHMM predict
573Phosphotyrosine(INSR)HMM predict
626SulfotyrosineHMM predict
691Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005400
  • Location:chr2 45732546-46268631
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 45724339 45724665 326 8045
CTCF CD4SISSRdata 45724339 45724665 326 8045
CTCF HelaGSE12889 45724364 45724628 264 8051
CTCF JurkatGSE12889 45724338 45724541 203 8107
CTCF G2GSE9613 45723978 45724957 979 8079
CTCF G2GSE9613 45730930 45732677 1747 743
H3K27me3 colorectalcancer 45722707 45722927 220 9730
H3K4me3 colorectalcancer 45730897 45731186 289 1505
HIF1 NormHepG2 45730554 45731262 708 1639
NFkBII GM10847GSE19485 45730285 45732805 2520 1002
Oct1 HelaGSE14283 45713297 45713343 46 19227
Rb GrowingGSE19898 45724579 45724747 168 7884
Rb QuiescentGSE19898 45731672 45731855 183 783
Rb SenescentGSE19898 45731612 45732014 402 734
USF1 HepG2E 45726097 45726461 364 6268
USF1 HepG2E 45727713 45729677 1964 3852
USF1 HepG2E 45729981 45731367 1386 1873
USF2 HepG2E 45729981 45731367 1386 1873
hScc1 BcellGSE12603 45724092 45724801 709 8100
hScc1 BcellGSE12603 45730680 45731907 1227 1253
hScc1 CdLSGSE12603 45724132 45725195 1063 7883
hScc1 G2GSE9613 45723875 45725088 1213 8065
p130 QuiescentGSE19898 45731147 45731470 323 1238
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 46276587 46276972 385 8148
hScc1 BcellGSE12603 46277908 46278497 589 9571
hScc1 BcellGSE12603 46281530 46281878 348 13073
p63 keratinocytesGSE17611 46272753 46273614 861 4552
p63 keratinocytesGSE17611 46278164 46279498 1334 10200
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
AR prostate-cancerGSE14092 46105561 46106188 627 0
CBP T30-glioblastomaGSE21026 46148035 46149119 1084 0
CBP T30-glioblastomaGSE21026 46177993 46179809 1816 0
CTCF CD4GSE12889 45859273 45859524 251 0
CTCF CD4GSE12889 46017140 46017302 162 0
CTCF CD4GSE12889 46091574 46091782 208 0
CTCF CD4GSE12889 46143574 46143904 330 0
CTCF CD4SISSRdata 45859273 45859524 251 0
CTCF CD4SISSRdata 46017140 46017302 162 0
CTCF CD4SISSRdata 46091574 46091782 208 0
CTCF CD4SISSRdata 46143574 46143904 330 0
CTCF HelaGSE12889 46143629 46143868 239 0
CTCF JurkatGSE12889 46017148 46017418 270 0
CTCF JurkatGSE12889 46110045 46110282 237 0
CTCF G2GSE9613 45773953 45774255 302 0
CTCF G2GSE9613 45789848 45790135 287 0
CTCF G2GSE9613 45815124 45815303 179 0
CTCF G2GSE9613 45852173 45852608 435 0
CTCF G2GSE9613 45854895 45855339 444 0
CTCF G2GSE9613 45858807 45860063 1256 0
CTCF G2GSE9613 45875741 45875932 191 0
CTCF G2GSE9613 45917162 45917432 270 0
CTCF G2GSE9613 45944196 45944508 312 0
CTCF G2GSE9613 45952927 45953173 246 0
CTCF G2GSE9613 46016444 46017425 981 0
CTCF G2GSE9613 46073978 46074551 573 0
CTCF G2GSE9613 46091135 46092183 1048 0
CTCF G2GSE9613 46117253 46117663 410 0
CTCF G2GSE9613 46126593 46126773 180 0
CTCF G2GSE9613 46143608 46143924 316 0
CTCF G2GSE9613 46163223 46163503 280 0
CTCF G2GSE9613 46243885 46244509 624 0
CTCF G2GSE9613 46244919 46245410 491 0
CTCF G2GSE9613 46248022 46248235 213 0
CTCF G2GSE9613 46252888 46253132 244 0
CTCF G2GSE9613 46259593 46260049 456 0
ER Breast-CancerGSE22609 45929782 45930024 242 0
ER E2-MCF7GSE14664 46047749 46047808 59 0
ER E2-MCF7GSE14664 46228549 46228593 44 0
ER MCF7GSE19013 45832763 45833619 856 0
ER MCF7GSE19013 45855163 45855715 552 0
ER MCF7GSE19013 46215142 46216016 874 0
FOXA1 MCF7GSE15244 45734651 45735249 598 0
FOXA1 MCF7GSE15244 45751211 45751784 573 0
FOXA1 MCF7GSE15244 45858987 45859853 866 0
FOXA1 MCF7GSE15244 45895968 45897325 1357 0
FOXA1 MCF7GSE15244 45902050 45903399 1349 0
FOXA1 MCF7GSE15244 46018846 46020179 1333 0
FOXA1 MCF7GSE15244 46023973 46025002 1029 0
FOXA1 MCF7GSE15244 46071965 46073840 1875 0
FOXA1 MCF7GSE15244 46083076 46083816 740 0
FOXA1 MCF7GSE15244 46113364 46114457 1093 0
FOXA1 MCF7GSE15244 46118765 46119385 620 0
FOXA1 MCF7GSE15244 46122690 46123682 992 0
FOXA1 MCF7GSE15244 46172785 46173585 800 0
FOXA1 MCF7GSE15244 46215097 46215944 847 0
FOXA1 MCF7GSE15244 46243853 46245814 1961 0
Fos K562GSE19551 46016818 46017427 609 0
FoxA1 MCF7MACSdata 45751265 45751594 329 0
FoxA1 MCF7MACSdata 45769455 45769603 148 0
FoxA1 MCF7MACSdata 45896070 45896455 385 0
FoxA1 MCF7MACSdata 46024373 46024556 183 0
FoxA1 MCF7MACSdata 46072945 46073357 412 0
FoxA1 MCF7MACSdata 46113607 46113837 230 0
FoxA1 MCF7MACSdata 46118887 46119169 282 0
FoxA1 MCF7MACSdata 46122883 46123155 272 0
FoxA1 MCF7MACSdata 46172917 46173253 336 0
FoxA1 MCF7MACSdata 46244798 46245130 332 0
KLF4 hESGSE17917 45809057 45809562 505 0
Myc K562GSE19551 46016736 46017297 561 0
Oct1 H2O2-HelaGSE14283 45885378 45885405 27 0
Oct1 H2O2-HelaGSE14283 45927438 45927474 36 0
Oct1 H2O2-HelaGSE14283 46035885 46035932 47 0
Oct1 H2O2-HelaGSE14283 46097517 46097557 40 0
Oct1 H2O2-HelaGSE14283 46130005 46130035 30 0
Oct1 H2O2-HelaGSE14283 46225187 46225216 29 0
Oct1 HelaGSE14283 46035887 46035932 45 0
Oct1 HelaGSE14283 46047749 46047790 41 0
Oct1 HelaGSE14283 46098262 46098299 37 0
Oct1 HelaGSE14283 46238818 46238848 30 0
P300 T0-glioblastomaGSE21026 45762033 45762843 810 0
P300 T0-glioblastomaGSE21026 46110071 46110613 542 0
P300 T0-glioblastomaGSE21026 46259718 46260712 994 0
P300 T30-glioblastomaGSE21026 45762194 45762944 750 0
P300 T30-glioblastomaGSE21026 46072436 46073816 1380 0
P300 T30-glioblastomaGSE21026 46148093 46149115 1022 0
P300 T30-glioblastomaGSE21026 46178029 46179828 1799 0
PAX3-FKHR Rh4GSE19063 45988963 45990152 1189 0
RARA MCF7GSE15244 45902126 45903068 942 0
RARA MCF7GSE15244 46018925 46020179 1254 0
RARA MCF7GSE15244 46072558 46073840 1282 0
RARA MCF7GSE15244 46113330 46115943 2613 0
RARA MCF7GSE15244 46118444 46119632 1188 0
RARA MCF7GSE15244 46122107 46123603 1496 0
RARA MCF7GSE15244 46148071 46149084 1013 0
RARA MCF7GSE15244 46215132 46216981 1849 0
RARA MCF7GSE15244 46243413 46246605 3192 0
RARA MCF7GSE15244 46251118 46253096 1978 0
RNAII Tamoxifen-MCF7GSE14664 46047744 46047796 52 0
Rb GrowingGSE19898 45824388 45824520 132 0
Rb GrowingGSE19898 45976312 45976470 158 0
Rb GrowingGSE19898 46232010 46232206 196 0
Rb QuiescentGSE19898 45824193 45824396 203 0
Rb QuiescentGSE19898 45969694 45969988 294 0
Rb SenescentGSE19898 45824079 45824442 363 0
Rb shRbQuiescentGSE19898 45977139 45977439 300 0
Rb shRbSenescenceGSE19898 45733059 45733230 171 0
STAT1 HeLaGSE12783 46147052 46149940 2888 0
TAF HelaGSE8489 46211092 46211298 206 0
TFAP2C MCF7GSE21234 45801787 45802296 509 0
TFAP2C MCF7GSE21234 45895913 45896504 591 0
TFAP2C MCF7GSE21234 45897455 45897961 506 0
TFAP2C MCF7GSE21234 45901870 45903387 1517 0
TFAP2C MCF7GSE21234 45931998 45932996 998 0
TFAP2C MCF7GSE21234 45990119 45990810 691 0
TFAP2C MCF7GSE21234 46019213 46020303 1090 0
TFAP2C MCF7GSE21234 46044596 46045359 763 0
TFAP2C MCF7GSE21234 46228949 46229461 512 0
TFAP2C MCF7GSE21234 46244568 46245454 886 0
TFAP2C MCF7GSE21234 46245461 46245951 490 0
hScc1 BcellGSE12603 45732740 45733053 313 0
hScc1 BcellGSE12603 45859057 45859547 490 0
hScc1 BcellGSE12603 45921041 45921374 333 0
hScc1 BcellGSE12603 46016879 46017386 507 0
hScc1 BcellGSE12603 46074046 46074726 680 0
hScc1 BcellGSE12603 46092007 46092183 176 0
hScc1 BcellGSE12603 46130480 46130824 344 0
hScc1 BcellGSE12603 46243971 46244919 948 0
hScc1 CdLSGSE12603 45858497 45859779 1282 0
hScc1 CdLSGSE12603 46016770 46017460 690 0
hScc1 CdLSGSE12603 46074017 46074628 611 0
hScc1 G2GSE9613 46016806 46017425 619 0
hScc1 G2GSE9613 46073936 46074726 790 0
hScc1 G2GSE9613 46091238 46092215 977 0
p130 QuiescentGSE19898 46094235 46094366 131 0
p130 QuiescentGSE19898 46149425 46149602 177 0
p130 QuiescentGSE19898 46251230 46251515 285 0
p130 SenescentGSE19898 45732848 45733217 369 0
p130 SenescentGSE19898 45733249 45733523 274 0
p130 SenescentGSE19898 45824206 45824542 336 0
p130 SenescentGSE19898 45930257 45930514 257 0
p63 keratinocytesGSE17611 45929521 45931092 1571 0
p63 keratinocytesGSE17611 45991085 45992027 942 0
p63 keratinocytesGSE17611 45999946 46001114 1168 0
p63 keratinocytesGSE17611 46214701 46216205 1504 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-205 hsa-mir-205 1 19244118
hsa-miR-21 hsa-mir-21 17 19633292
hsa-miR-21* hsa-mir-21 17 19633292
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
14234 mRNA PRKCE chr2 45790693 46326779 868 mRNA chr2 46325649 46326517Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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