AutismKB 2.0

Annotation Detail for PRKCH


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Basic Information Top
Gene Symbol:PRKCH ( MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta )
Gene Full Name: protein kinase C, eta
Band: 14q23.1
Quick LinksEntrez ID:5583; OMIM: 605437; Uniprot ID:KPCL_HUMAN; ENSEMBL ID: ENSG00000027075; HGNC ID: 9403
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28Phosphoserine; by autocatalysis
32Phosphoserine; by autocatalysis
57Phosphothreonine.
317Phosphoserine.
320Phosphoserine.
513Phosphothreonine (Probable).
656Phosphothreonine (Probable).
675Phosphoserine.
Location(AA) Modifications Resource
512Phosphothreonine (Probable).Swiss-Prot 53.0
655Phosphothreonine (Probable).Swiss-Prot 53.0
674Phosphoserine (Probable).Swiss-Prot 53.0
Location(AA) Modification Resource
68Phosphotyrosine(EGFR)HMM predict
75N-linkedHMM predict
99N-linkedHMM predict
200Phosphotyrosine(EGFR)HMM predict
252Phosphotyrosine(Syk)HMM predict
263Phosphoserine(CK1)HMM predict
314N-linkedHMM predict
316Phosphoserine(CDC2)HMM predict
326Phosphothreonine(PKC)HMM predict
334Phosphoserine(PKG)HMM predict
335Phosphoserine(CK1)HMM predict
344N-linkedHMM predict
347N-linkedHMM predict
380Phosphotyrosine(Abl)HMM predict
424Phosphothreonine(CDC2)HMM predict
512O-linkedHMM predict
519Phosphotyrosine(INSR)HMM predict
591N-linkedHMM predict
672N-linkedHMM predict
675Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006255
  • Location:chr14 60858267-61087447
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 61089340 61090820 1480 2633
ER MCF7GSE19013 61095542 61096523 981 8585
Fos K562GSE19551 61096031 61096939 908 9038
H3ac HepG2E 61096594 61097045 451 9372
P300 T0-glioblastomaGSE21026 61090160 61090757 597 3011
P300 T30-glioblastomaGSE21026 61089104 61091230 2126 2720
RARA MCF7GSE15244 61090309 61090727 418 3071
RARG MCF7GSE15244 61090309 61090665 356 3040
RARG MCF7GSE15244 61097845 61099151 1306 11051
RARG MCF7GSE15244 61106435 61107247 812 19394
Rb GrowingGSE19898 61090276 61090568 292 2975
TFAP2C MCF7GSE21234 61090190 61090953 763 3124
USF1 HepG2E 61094920 61095276 356 7651
USF1 HepG2E 61096594 61097045 451 9372
USF1 HepG2E 61097557 61099402 1845 11032
USF2 HepG2E 61090309 61090763 454 3089
USF2 HepG2E 61096594 61097045 451 9372
hScc1 BcellGSE12603 61104204 61105840 1636 17575
p130 SenescentGSE19898 61098255 61098891 636 11126
p130 shRbSenescentGSE19898 61090297 61090469 172 2936
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 60987903 60990047 2144 0
CBP T30-glioblastomaGSE21026 61012901 61013845 944 0
CTCF CD4GSE12889 60993079 60993540 461 0
CTCF CD4SISSRdata 60993079 60993540 461 0
CTCF HelaGSE12889 60993205 60993422 217 0
CTCF G2GSE9613 60870873 60871046 173 0
CTCF G2GSE9613 60918214 60918390 176 0
CTCF G2GSE9613 60993098 60993628 530 0
CTCF G2GSE9613 60995638 60995780 142 0
CTCF G2GSE9613 60998260 60998581 321 0
ER E2-MCF7GSE14664 61042086 61042123 37 0
ER Fulvestrant-MCF7GSE14664 61010634 61010670 36 0
ER Fulvestrant-MCF7GSE14664 61025003 61025052 49 0
ER Fulvestrant-MCF7GSE14664 61025264 61025296 32 0
ER Fulvestrant-MCF7GSE14664 61042087 61042123 36 0
ER MCF7GSE19013 60918088 60918820 732 0
ER MCF7GSE19013 61021468 61022135 667 0
FOXA1 MCF7GSE15244 60975312 60976291 979 0
FOXA1 MCF7GSE15244 61073800 61074789 989 0
FoxA1 MCF7MACSdata 60946290 60946560 270 0
FoxA1 MCF7MACSdata 60966845 60966994 149 0
FoxA1 MCF7MACSdata 61074003 61074564 561 0
Oct1 H2O2-HelaGSE14283 60877456 60877487 31 0
Oct1 H2O2-HelaGSE14283 60904468 60904510 42 0
Oct1 H2O2-HelaGSE14283 61018628 61018672 44 0
Oct1 H2O2-HelaGSE14283 61025023 61025093 70 0
Oct1 H2O2-HelaGSE14283 61056508 61056536 28 0
Oct1 HelaGSE14283 60876284 60876317 33 0
Oct1 HelaGSE14283 60877456 60877500 44 0
Oct1 HelaGSE14283 60878619 60878651 32 0
Oct1 HelaGSE14283 60898063 60898110 47 0
Oct1 HelaGSE14283 60904472 60904510 38 0
Oct1 HelaGSE14283 60916929 60916964 35 0
Oct1 HelaGSE14283 60917506 60917533 27 0
Oct1 HelaGSE14283 61010636 61010672 36 0
Oct1 HelaGSE14283 61018632 61018672 40 0
Oct1 HelaGSE14283 61025006 61025044 38 0
Oct1 HelaGSE14283 61025261 61025311 50 0
Oct1 HelaGSE14283 61042091 61042125 34 0
Pol3 GM12878GSE19551 61029729 61029968 239 0
RARA MCF7GSE15244 60892241 60893086 845 0
RARA MCF7GSE15244 60904599 60905381 782 0
RARA MCF7GSE15244 60924734 60925013 279 0
RARA MCF7GSE15244 60946210 60946607 397 0
RARA MCF7GSE15244 60975436 60976646 1210 0
RARA MCF7GSE15244 60997870 60998581 711 0
RARA MCF7GSE15244 60998886 60999303 417 0
RARA MCF7GSE15244 61008038 61009300 1262 0
RARA MCF7GSE15244 61018767 61019652 885 0
RARA MCF7GSE15244 61021494 61022075 581 0
RARA MCF7GSE15244 61026447 61027003 556 0
RARA MCF7GSE15244 61028779 61029565 786 0
RARA MCF7GSE15244 61045348 61046042 694 0
RARA MCF7GSE15244 61047814 61048854 1040 0
RARA MCF7GSE15244 61050451 61051054 603 0
RARA MCF7GSE15244 61061148 61063638 2490 0
RARA MCF7GSE15244 61073591 61074825 1234 0
RARG MCF7GSE15244 60892277 60893086 809 0
RARG MCF7GSE15244 60893467 60893721 254 0
RARG MCF7GSE15244 60903642 60904161 519 0
RARG MCF7GSE15244 60904490 60905005 515 0
RARG MCF7GSE15244 60924734 60925194 460 0
RARG MCF7GSE15244 60975436 60976500 1064 0
RARG MCF7GSE15244 60997842 60998442 600 0
RARG MCF7GSE15244 60998886 60999303 417 0
RARG MCF7GSE15244 61007238 61008108 870 0
RARG MCF7GSE15244 61008635 61009043 408 0
RARG MCF7GSE15244 61018767 61019652 885 0
RARG MCF7GSE15244 61021567 61022075 508 0
RARG MCF7GSE15244 61026583 61027003 420 0
RARG MCF7GSE15244 61028779 61029447 668 0
RARG MCF7GSE15244 61042583 61042964 381 0
RARG MCF7GSE15244 61045646 61046042 396 0
RARG MCF7GSE15244 61046411 61048537 2126 0
RARG MCF7GSE15244 61050451 61051360 909 0
RARG MCF7GSE15244 61051779 61052061 282 0
RARG MCF7GSE15244 61061254 61063826 2572 0
RARG MCF7GSE15244 61073348 61074789 1441 0
RNAII Tamoxifen-MCF7GSE14664 60877464 60877501 37 0
STAT1 HeLaGSE12783 61060588 61064724 4136 0
STAT1 HeLaGSE12783 61072450 61074974 2524 0
Sox2 hESGSE18292 61060555 61061258 703 0
TFAP2C MCF7GSE21234 60904772 60905244 472 0
TFAP2C MCF7GSE21234 60917529 60918521 992 0
TFAP2C MCF7GSE21234 60924680 60925096 416 0
TFAP2C MCF7GSE21234 61018826 61019933 1107 0
TFAP2C MCF7GSE21234 61021686 61022222 536 0
TFAP2C MCF7GSE21234 61061488 61062380 892 0
TFAP2C MCF7GSE21234 61062641 61063900 1259 0
TFAP2C MCF7GSE21234 61069758 61070370 612 0
USF1 HepG2E 61072008 61074825 2817 0
USF2 HepG2E 61073311 61073699 388 0
USF2 HepG2E 61073953 61074661 708 0
hScc1 BcellGSE12603 60918178 60918390 212 0
hScc1 BcellGSE12603 60993071 60993593 522 0
hScc1 BcellGSE12603 60997704 60998581 877 0
hScc1 BcellGSE12603 61011753 61012014 261 0
hScc1 BcellGSE12603 61047675 61047881 206 0
hScc1 CdLSGSE12603 60975436 60976166 730 0
hScc1 CdLSGSE12603 60993035 60993593 558 0
hScc1 CdLSGSE12603 60998047 60998581 534 0
hScc1 CdLSGSE12603 61011730 61012177 447 0
p130 QuiescentGSE19898 61006706 61006892 186 0
p130 QuiescentGSE19898 61083926 61084189 263 0
p130 shRbSenescentGSE19898 61065297 61065470 173 0
p63 keratinocytesGSE17611 60962307 60963054 747 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125b hsa-mir-125b-1 11 21199010
hsa-miR-125b hsa-mir-125b-2 21 21199010
hsa-miR-1296 hsa-mir-1296 10 21199010
hsa-miR-151-3p hsa-mir-151 8 21199010
hsa-miR-151-5p hsa-mir-151 8 21199010
hsa-miR-200a hsa-mir-200a 1 21199010
hsa-miR-200a* hsa-mir-200a 1 21199010
hsa-miR-20b* hsa-mir-20b X 21199010
hsa-miR-216a hsa-mir-216a 2 21199010
hsa-miR-223* hsa-mir-223 X 21199010
hsa-miR-28-5p hsa-mir-28 3 21199010
hsa-miR-296-3p hsa-mir-296 20 21199010
hsa-miR-99a hsa-mir-99a 21 21199010
hsa-miR-99a* hsa-mir-99a 21 21199010
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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