AutismKB 2.0

Annotation Detail for CAND1


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Basic Information Top
Gene Symbol:CAND1 ( DKFZp434M1414,FLJ10114,FLJ10929,FLJ38691,FLJ90441,KIAA0829,TIP120,TIP120A )
Gene Full Name: cullin-associated and neddylation-dissociated 1
Band: 12q14.3-q15
Quick LinksEntrez ID:55832; OMIM: 607727; Uniprot ID:CAND1_HUMAN; ENSEMBL ID: ENSG00000111530; HGNC ID: 30688
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
55N6-acetyllysine.
335Phosphoserine.
340Phosphoserine.
624Phosphothreonine.
971N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
121O-linkedHMM predict
122O-linkedHMM predict
135Phosphothreonine(PKA)HMM predict
195Phosphothreonine(PKA)HMM predict
223Phosphoserine(CK1)HMM predict
225N-linkedHMM predict
227Phosphoserine(IKK)HMM predict
229Phosphoserine(CK1)HMM predict
311SulfotyrosineHMM predict
335Phosphoserine(CK2)HMM predict
335Phosphoserine(CK2)HMM predict
339SulfotyrosineHMM predict
339Phosphotyrosine(Syk)HMM predict
339Phosphotyrosine(INSR)HMM predict
340Phosphoserine(CK1)HMM predict
340Phosphoserine(CK2)HMM predict
372Phosphotyrosine(Syk)HMM predict
423Phosphothreonine(MAPK)HMM predict
430Phosphoserine(ATM)HMM predict
507N-linkedHMM predict
558Phosphoserine(IKK)HMM predict
628Phosphothreonine(PKC)HMM predict
638Phosphoserine(CDC2)HMM predict
680N-linkedHMM predict
684O-linkedHMM predict
728Phosphoserine(CK1)HMM predict
772Phosphotyrosine(INSR)HMM predict
807Phosphothreonine(PKC)HMM predict
828Phosphoserine(PKG)HMM predict
866Phosphoserine(CK1)HMM predict
867Phosphoserine(CDC2)HMM predict
901Phosphoserine(ATM)HMM predict
1054N-linkedHMM predict
1215IsoleucineHMM predict
1220Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_018448
  • Location:chr12 65949415-65994186
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65937377 65937508 131 11973
ER E2-MCF7GSE14664 65936704 65936741 37 12693
ER Fulvestrant-MCF7GSE14664 65936702 65936742 40 12694
ETS1 JurkatGSE17954 65948231 65950481 2250 60
FOXA1 MCF7GSE15244 65948854 65949362 508 308
Fos K562GSE19551 65948474 65949667 1193 345
GATA3 MCF7GSE15244 65946240 65946730 490 2931
H3ac HepG2E 65948221 65949328 1107 641
KLF4 hESGSE17917 65948822 65949122 300 444
PHF8 293TGSE20725 65948270 65950468 2198 47
PHF8 Hs68plusFBSGSE20725 65948102 65950725 2623 2
RARA MCF7GSE15244 65948252 65949432 1180 574
RARG MCF7GSE15244 65945956 65946602 646 3137
RARG MCF7GSE15244 65948450 65949727 1277 327
TAF HelaGSE8489 65942864 65943286 422 6341
TAF HelaGSE8489 65948379 65949328 949 562
USF1 HepG2E 65948740 65949328 588 382
USF2 HepG2E 65948854 65949218 364 380
p130 shRbQuiescentGSE19898 65948400 65949646 1246 393
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 66002925 66002953 28 8753
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65948995 65950422 1427 0
ER E2-MCF7GSE14664 65962121 65962205 84 0
ER MCF7GSE19013 65955475 65956243 768 0
FOXA1 DLD1GSE12801 65955603 65956282 679 0
FOXA1 MCF7GSE15244 65955603 65956282 679 0
FoxA1 MCF7MACSdata 65955719 65955944 225 0
H3K4me3 colorectalcancer 65950175 65951070 895 0
H3ac HepG2E 65950175 65951604 1429 0
Oct1 H2O2-HelaGSE14283 65988919 65988970 51 0
Oct1 HelaGSE14283 65984715 65984747 32 0
Oct1 HelaGSE14283 65988918 65988991 73 0
PHF8 HeLaGSE20725 65948415 65950460 2045 0
RARA MCF7GSE15244 65955603 65956393 790 0
RARG MCF7GSE15244 65955603 65956250 647 0
Rb shRbQuiescentGSE19898 65957483 65957654 171 0
TAF HelaGSE8489 65950606 65951308 702 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-148a hsa-mir-148a 7 20820187
hsa-miR-148a* hsa-mir-148a 7 20820187
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1142 Unknown pSILAC miR-1 CAND1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000111530 n_a n_a n_a "epithelium, lymphoblast, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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