AutismKB 2.0

Annotation Detail for PKN1


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Basic Information Top
Gene Symbol:PKN1 ( DBK,MGC46204,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1 )
Gene Full Name: protein kinase N1
Band: 19p13.12
Quick LinksEntrez ID:5585; OMIM: 601032; Uniprot ID:PKN1_HUMAN; ENSEMBL ID: ENSG00000123143; HGNC ID: 9405
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
205Phosphoserine.
353Phosphothreonine.
374Phosphoserine (By similarity).
376Phosphoserine.
448N6-acetyllysine.
533Phosphoserine.
537Phosphoserine.
559Phosphoserine.
561Phosphoserine.
562Phosphoserine.
774Phosphothreonine (Probable).
778Phosphothreonine.
914Phosphothreonine.
916Phosphoserine.
Location(AA) Modifications Resource
376Phosphoserine.Swiss-Prot 53.0
376PhosphoserinePhospho.ELM 6.0
562Phosphoserine.Swiss-Prot 53.0
774Phosphothreonine (Probable).Swiss-Prot 53.0
774Phosphothreonine (PDK-1)Phospho.ELM 6.0
916Phosphoserine.Swiss-Prot 53.0
916PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
12Phosphoserine(IKK)HMM predict
14Phosphoserine(IKK)HMM predict
63Phosphothreonine(PKA)HMM predict
64Phosphothreonine(PKA)HMM predict
119O-linkedHMM predict
153Phosphoserine(IKK)HMM predict
154N-linkedHMM predict
251Phosphoserine(CAMK2)HMM predict
343N-linkedHMM predict
353Phosphothreonine(CDC2)HMM predict
353Phosphothreonine(MAPK)HMM predict
353Phosphothreonine(CDK)HMM predict
374Phosphoserine(CAMK2)HMM predict
374Phosphoserine(IKK)HMM predict
376Phosphoserine(ATM)HMM predict
380Phosphoserine(PKG)HMM predict
387N-linkedHMM predict
389O-linkedHMM predict
406O-linkedHMM predict
525N-linkedHMM predict
533Phosphoserine(CAMK2)HMM predict
533O-linkedHMM predict
533Phosphoserine(CDC2)HMM predict
537Phosphoserine(CDC2)HMM predict
540O-linkedHMM predict
540O-linkedHMM predict
545Phosphothreonine(PKC)HMM predict
562Phosphoserine(CDC2)HMM predict
562Phosphoserine(CDK)HMM predict
572Phosphoserine(IKK)HMM predict
573Phosphoserine(MAPK)HMM predict
573Phosphoserine(CDC2)HMM predict
573O-linkedHMM predict
575Phosphoserine(CK1)HMM predict
576Phosphoserine(IKK)HMM predict
578Phosphoserine(CK1)HMM predict
579Phosphoserine(CDC2)HMM predict
579PhosphoserineHMM predict
591O-linkedHMM predict
596Phosphothreonine(MAPK)HMM predict
608Phosphoserine(CDC2)HMM predict
687Phosphothreonine(CDC2)HMM predict
687Phosphothreonine(MAPK)HMM predict
713Phosphoserine(CK1)HMM predict
753Phosphotyrosine(INSR)HMM predict
753Phosphotyrosine(Syk)HMM predict
774PhosphothreonineHMM predict
774PhosphothreonineHMM predict
935PhenylalanineHMM predict
937PhenylalanineHMM predict
938PhenylalanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002741
  • Location:chr19 14405165-14443677
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 14403770 14404083 313 1239
CTCF CD4SISSRdata 14403770 14404083 313 1239
CTCF G2GSE9613 14403673 14404061 388 1299
Rb QuiescentGSE19898 14404745 14405024 279 281
Rb SenescentGSE19898 14403779 14404026 247 1263
hScc1 BcellGSE12603 14403673 14404061 388 1299
hScc1 CdLSGSE12603 14403673 14404061 388 1299
p130 QuiescentGSE19898 14404516 14404735 219 540
p130 shRbSenescentGSE19898 14404866 14405049 183 208
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 14406491 14407278 787 0
USF1 HepG2E 14405851 14406774 923 0
hScc1 BcellGSE12603 14405647 14406552 905 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-377 hsa-mir-377 14 18716028
hsa-miR-377 hsa-mir-377 14 18716028
hsa-miR-377* hsa-mir-377 14 18716028
hsa-miR-377* hsa-mir-377 14 18716028
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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