AutismKB 2.0

Annotation Detail for PRKD1


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Basic Information Top
Gene Symbol:PRKD1 ( PKC-MU,PKCM,PKD,PRKCM )
Gene Full Name: protein kinase D1
Band: 14q12
Quick LinksEntrez ID:5587; OMIM: 605435; Uniprot ID:KPCD1_HUMAN; ENSEMBL ID: ENSG00000184304; HGNC ID: 9407
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
95Phosphotyrosine.
205Phosphoserine.
208Phosphoserine.
210Phosphothreonine.
217Phosphothreonine.
235Phosphoserine.
237Phosphoserine.
247Phosphoserine.
249Phosphoserine.
345Phosphoserine.
379Phosphoserine.
395Phosphothreonine.
397Phosphoserine.
399Phosphoserine.
400Phosphothreonine.
401Phosphoserine.
420Phosphoserine.
432Phosphotyrosine.
448Phosphoserine.
460Phosphoserine.
463Phosphotyrosine.
473Phosphoserine.
502Phosphotyrosine.
548Phosphoserine.
549Phosphoserine.
738Phosphoserine; by PKC (By similarity).
742Phosphoserine; by autocatalysis.
888Phosphoserine.
890Phosphoserine.
910Phosphoserine; by autocatalysis (By
Location(AA) Modifications Resource
205Phosphoserine (By similarity).Swiss-Prot 53.0
205Phosphoserine (PKD1)Phospho.ELM 6.0
208PhosphoserinePhospho.ELM 6.0
219PhosphoserinePhospho.ELM 6.0
223PhosphoserinePhospho.ELM 6.0
249Phosphoserine (PKC
432Phosphotyrosine (Abl;Src)Phospho.ELM 6.0
463Phosphotyrosine (Abl;Src)Phospho.ELM 6.0
502Phosphotyrosine (Abl;Src)Phospho.ELM 6.0
738Phosphoserine (PKC alpha;PK)Phospho.ELM 6.0
742Phosphoserine (PKC alpha;PK)Phospho.ELM 6.0
910Phosphoserine (PKD1)Phospho.ELM 6.0
910Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
11O-linkedHMM predict
11Phosphoserine(IKK)HMM predict
11Phosphoserine(CDC2)HMM predict
31Phosphoserine(IKK)HMM predict
31O-linkedHMM predict
72Phosphotyrosine(INSR)HMM predict
180S-palmitoylHMM predict
195N-linkedHMM predict
205Phosphoserine(PKG)HMM predict
205Phosphoserine(PKA)HMM predict
206N-linkedHMM predict
214O-linkedHMM predict
224O-linkedHMM predict
224O-linkedHMM predict
235Phosphoserine(IKK)HMM predict
237PhosphoserineHMM predict
247Phosphoserine(IKK)HMM predict
249Phosphoserine(ATM)HMM predict
249Phosphoserine(PKA)HMM predict
308S-palmitoylHMM predict
332Phosphoserine(MAPK)HMM predict
345Phosphoserine(CK2)HMM predict
348N-linkedHMM predict
350Phosphoserine(CK2)HMM predict
353N-linkedHMM predict
393N-linkedHMM predict
397Phosphoserine(CDK)HMM predict
397Phosphoserine(CDC2)HMM predict
416Phosphothreonine(PKC)HMM predict
420Phosphoserine(PKG)HMM predict
422Phosphothreonine(PKC)HMM predict
437Phosphothreonine(PKC)HMM predict
456N-linkedHMM predict
463Phosphotyrosine(EGFR)HMM predict
463Phosphotyrosine(Syk)HMM predict
509N-linkedHMM predict
512Phosphoserine(CDC2)HMM predict
512Phosphoserine(CDK)HMM predict
512O-linkedHMM predict
514Phosphoserine(IKK)HMM predict
548O-linkedHMM predict
605Phosphothreonine(PKA)HMM predict
651Phosphothreonine(CDC2)HMM predict
742Phosphoserine(PKA)HMM predict
760Phosphotyrosine(Jak)HMM predict
886N-linkedHMM predict
894Phosphothreonine(MAPK)HMM predict
894Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002742
  • Location:chr14 29115439-29466649
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 29480360 29480853 493 13957
Oct1 HelaGSE14283 29475210 29475268 58 8590
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 29110496 29110537 41 4923
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 29346794 29347571 777 0
CTCF G2GSE9613 29466078 29467033 955 0
ER E2-MCF7GSE14664 29344942 29344978 36 0
ER E2-MCF7GSE14664 29389612 29389646 34 0
ER E2-MCF7GSE14664 29400032 29400064 32 0
ER E2-MCF7GSE14664 29417754 29417786 32 0
ER Fulvestrant-MCF7GSE14664 29343146 29343181 35 0
FOXA1 MCF7GSE15244 29263942 29264410 468 0
FOXA1 MCF7GSE15244 29435351 29435726 375 0
Fos K562GSE19551 29344635 29345123 488 0
FoxA1 MCF7MACSdata 29264026 29264279 253 0
FoxA1 MCF7MACSdata 29435347 29435776 429 0
NRSF JurkatGSE13047 29263891 29264539 648 0
NRSF mAbJurkat 29261637 29263440 1803 0
NRSF mAbJurkat 29263906 29265780 1874 0
NRSF-mono JurkatQuESTdata 29263890 29264508 618 0
NRSF-poly JurkatQuESTdata 29263930 29264391 461 0
Nanog hESGSE18292 29145578 29145951 373 0
Oct1 H2O2-HelaGSE14283 29192909 29192938 29 0
Oct1 H2O2-HelaGSE14283 29207426 29207473 47 0
Oct1 H2O2-HelaGSE14283 29331548 29331584 36 0
Oct1 H2O2-HelaGSE14283 29366804 29366832 28 0
Oct1 H2O2-HelaGSE14283 29398586 29398624 38 0
Oct1 H2O2-HelaGSE14283 29408925 29408954 29 0
Oct1 H2O2-HelaGSE14283 29429270 29429297 27 0
Oct1 HelaGSE14283 29158641 29158695 54 0
Oct1 HelaGSE14283 29159024 29159076 52 0
Oct1 HelaGSE14283 29182004 29182041 37 0
Oct1 HelaGSE14283 29192909 29192938 29 0
Oct1 HelaGSE14283 29196043 29196081 38 0
Oct1 HelaGSE14283 29207429 29207500 71 0
Oct1 HelaGSE14283 29268803 29268839 36 0
Oct1 HelaGSE14283 29331542 29331590 48 0
Oct1 HelaGSE14283 29343143 29343182 39 0
Oct1 HelaGSE14283 29366805 29366834 29 0
Oct1 HelaGSE14283 29382970 29382999 29 0
Oct1 HelaGSE14283 29392488 29392524 36 0
Oct1 HelaGSE14283 29463876 29463912 36 0
P300 T0-glioblastomaGSE21026 29123837 29124603 766 0
P300 T0-glioblastomaGSE21026 29182319 29182803 484 0
P300 T30-glioblastomaGSE21026 29344424 29344961 537 0
RARA MCF7GSE15244 29263804 29264410 606 0
RARA MCF7GSE15244 29360960 29361851 891 0
RARA MCF7GSE15244 29445512 29445758 246 0
RARG MCF7GSE15244 29263978 29264410 432 0
Rb shRbQuiescentGSE19898 29350598 29350751 153 0
TFAP2C MCF7GSE21234 29434449 29434887 438 0
hScc1 BcellGSE12603 29466140 29466416 276 0
hScc1 CdLSGSE12603 29465974 29466445 471 0
p130 SenescentGSE19898 29140626 29140951 325 0
p130 SenescentGSE19898 29288391 29288681 290 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-124 hsa-mir-124-1 8 18042700
hsa-miR-124 hsa-mir-124-2 8 18042700
hsa-miR-124 hsa-mir-124-3 20 18042700
hsa-miR-17 hsa-mir-17 13 20215348
hsa-miR-17* hsa-mir-17 13 20215348
hsa-miR-217 hsa-mir-217 2 19102782
hsa-miR-31 hsa-mir-31 9 19102782
hsa-miR-31* hsa-mir-31 9 19102782
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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