Annotation Detail for PBK

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Basic Information Top

Gene Symbol:	PBK ( CT84,FLJ14385,Nori-3,SPK,TOPK )
Gene Full Name:	PDZ binding kinase
Band:	8p21.1
Quick Links	Entrez ID:55872; OMIM: 611210; Uniprot ID:TOPK_HUMAN; ENSEMBL ID: ENSG00000168078; HGNC ID: 18282
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:6 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:8 results

Location(AA)	Modification
1	N-acetylmethionine.
9	Phosphothreonine.
24	Phosphothreonine.
32	Phosphoserine.
59	Phosphoserine.
200	Phosphothreonine (By similarity).

Location(AA)	Modification	Resource
11	Phosphoserine(PKC)	HMM predict
134	Phosphoserine(ATM)	HMM predict
196	N-linked	HMM predict
249	N-linked	HMM predict
252	N-linked	HMM predict
264	Phosphoserine(CK2)	HMM predict
271	Phosphotyrosine(Syk)	HMM predict
272	Phosphotyrosine(Syk)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_018492
Location:chr8 27723058-27751267
strand:-

Upstream the gene:5 results
Downstream the gene:0 results
Inside the gene:19 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
KLF4	hES	GSE17917	27756696	27756871	175	5516
LIN9	G0	GSE7516	27750317	27752291	1974	37
Oct4	hES	GSE17917	27756716	27756866	150	5524
P300	T30-glioblastoma	GSE21026	27750718	27751830	1112	7
TFAP2C	MCF7	GSE21234	27751027	27751599	572	46

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
E2F4	G0	GSE7516	27750745	27751599	854	0
ER	E2-MCF7	GSE14664	27729597	27729631	34	0
H3K4me2	HCT116	GSE10453	27749732	27750427	695	0
H3K4me3	colorectal	cancer	27750391	27751114	723	0
H3ac	HepG2	E	27749407	27751771	2364	0
LIN54	G0	GSE7516	27750827	27751536	709	0
LIN9	S	GSE7516	27750062	27752006	1944	0
Oct1	H2O2-Hela	GSE14283	27737506	27737534	28	0
Oct1	Hela	GSE14283	27725197	27725229	32	0
P300	T0-glioblastoma	GSE21026	27750799	27751685	886	0
PHF8	293T	GSE20725	27750843	27751633	790	0
TAF	Hela	GSE8489	27750548	27750998	450	0
TAF	k562	GSE8489	27749511	27752257	2746	0
p130	Quiescent	GSE19898	27750848	27751643	795	0
p130	Senescent	GSE19898	27750567	27751875	1308	0
p130	shRbQuiescent	GSE19898	27750702	27751799	1097	0
p130	shRbSenescent	GSE19898	27750703	27751683	980	0
p130	G0	GSE7516	27750464	27751736	1272	0
p130	S	GSE7516	27750718	27751701	983	0

Validated miRNA targets

miR Walk:7 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
25220	HTC	ESCO2	chr8	27687991	27726060	3002	mRNA	PBK	chr8	27723058	27751268	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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