AutismKB 2.0

Annotation Detail for PRKDC


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Basic Information Top
Gene Symbol:PRKDC ( DNA-PKcs,DNAPK,DNPK1,HYRC,HYRC1,XRCC7,p350 )
Gene Full Name: protein kinase, DNA-activated, catalytic polypeptide
Band: 8q11.21
Quick LinksEntrez ID:5591; OMIM: 600899; Uniprot ID:PRKDC_HUMAN; ENSEMBL ID: ENSG00000121031; HGNC ID: 9413
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
117N6-acetyllysine.
254N6-acetyllysine.
511Phosphoserine.
828N6-acetyllysine.
832N6-acetyllysine.
841Phosphoserine.
893Phosphoserine.
1052Phosphoserine.
1057N6-acetyllysine.
1209N6-acetyllysine.
1970N6-acetyllysine.
2117Phosphoserine.
2259N6-acetyllysine.
2603Phosphothreonine.
2609Phosphothreonine; by autocatalysis.
2612Phosphoserine; by autocatalysis.
2638Phosphothreonine; by autocatalysis.
2647Phosphothreonine; by autocatalysis.
2649Phosphothreonine.
2671Phosphothreonine.
2672Phosphoserine.
2743Phosphotyrosine.
3205Phosphoserine.
3241N6-acetyllysine.
3260N6-acetyllysine.
3608N6-acetyllysine.
3621N6-acetyllysine.
3638N6-acetyllysine.
3642N6-acetyllysine.
4026Phosphoserine.
Location(AA) Modifications Resource
2056Phosphoserine (DNA-PK)Phospho.ELM 6.0
2603Phosphothreonine.Swiss-Prot 53.0
2603PhosphothreoninePhospho.ELM 6.0
2609Phosphothreonine (by autocatalysis).Swiss-Prot 53.0
2609Phosphothreonine (DNA-PK)Phospho.ELM 6.0
2612Phosphoserine (DNA-PK)Phospho.ELM 6.0
2612Phosphoserine (by autocatalysis).Swiss-Prot 53.0
2620Phosphothreonine (DNA-PK)Phospho.ELM 6.0
2624PhosphoserinePhospho.ELM 6.0
2638Phosphothreonine (DNA-PK)Phospho.ELM 6.0
2638Phosphothreonine (by autocatalysis).Swiss-Prot 53.0
2647Phosphothreonine (by autocatalysis).Swiss-Prot 53.0
2647Phosphothreonine (DNA-PK)Phospho.ELM 6.0
2649PhosphothreoninePhospho.ELM 6.0
2649Phosphothreonine.Swiss-Prot 53.0
3205PhosphoserinePhospho.ELM 6.0
3205Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
47Phosphoserine(CDC2)HMM predict
209Phosphothreonine(PKA)HMM predict
233N-linkedHMM predict
244Phosphothreonine(PKC)HMM predict
265Phosphotyrosine(INSR)HMM predict
280Phosphoserine(ATM)HMM predict
314Phosphoserine(PKG)HMM predict
385Phosphotyrosine(EGFR)HMM predict
408Phosphotyrosine(Syk)HMM predict
457S-palmitoylHMM predict
458S-palmitoylHMM predict
503Phosphoserine(CK2)HMM predict
516Phosphothreonine(PKC)HMM predict
554N-linkedHMM predict
559Phosphoserine(CK1)HMM predict
694Phosphoserine(CDC2)HMM predict
694Phosphoserine(IKK)HMM predict
694Phosphoserine(ATM)HMM predict
789SulfotyrosineHMM predict
806Phosphoserine(CK2)HMM predict
847Phosphoserine(CK1)HMM predict
1032S-palmitoylHMM predict
1052Phosphoserine(CDC2)HMM predict
1086Phosphotyrosine(EGFR)HMM predict
1094Phosphoserine(CK1)HMM predict
1120Phosphoserine(CK1)HMM predict
1201N-linkedHMM predict
1205N-linkedHMM predict
1320N-linkedHMM predict
1331N-linkedHMM predict
1350N-linkedHMM predict
1502Phosphoserine(MAPK)HMM predict
1542O-linkedHMM predict
1546Phosphoserine(ATM)HMM predict
1641Phosphothreonine(PKC)HMM predict
1662N-linkedHMM predict
1753Phosphoserine(ATM)HMM predict
1790Phosphoserine(PKA)HMM predict
1790Phosphoserine(IKK)HMM predict
1802Phosphotyrosine(Syk)HMM predict
1818Phosphoserine(PKA)HMM predict
1859N-linkedHMM predict
1894Phosphoserine(PKG)HMM predict
2037Phosphoserine(CK1)HMM predict
2041Phosphoserine(ATM)HMM predict
2063Phosphothreonine(PKC)HMM predict
2063Phosphothreonine(PKA)HMM predict
2201Phosphothreonine(MAPK)HMM predict
2201O-linkedHMM predict
2316Phosphotyrosine(Syk)HMM predict
2484Phosphotyrosine(Syk)HMM predict
2489Phosphoserine(IKK)HMM predict
2493N-linkedHMM predict
2495Phosphoserine(ATM)HMM predict
2572SulfotyrosineHMM predict
2609PhosphothreonineHMM predict
2638PhosphothreonineHMM predict
2672Phosphoserine(MAPK)HMM predict
2831N-linkedHMM predict
2845N-linkedHMM predict
2963Phosphoserine(CK1)HMM predict
3036Phosphotyrosine(EGFR)HMM predict
3036Phosphotyrosine(SRC)HMM predict
3040Phosphotyrosine(Syk)HMM predict
3083Phosphoserine(ATM)HMM predict
3113N-linkedHMM predict
3150N-linkedHMM predict
3153Phosphoserine(ATM)HMM predict
3198Phosphothreonine(MAPK)HMM predict
3229Phosphoserine(CK1)HMM predict
3281S-palmitoylHMM predict
3311N-linkedHMM predict
3365Phosphoserine(CK1)HMM predict
3365Phosphoserine(CK2)HMM predict
3370Phosphoserine(CK1)HMM predict
3430N-linkedHMM predict
3432Phosphoserine(CK2)HMM predict
3442Phosphotyrosine(EGFR)HMM predict
3541Phosphoserine(IKK)HMM predict
3541O-linkedHMM predict
3599Phosphothreonine(CDC2)HMM predict
3727Phosphothreonine(PKC)HMM predict
3779Phosphoserine(IKK)HMM predict
3782Phosphoserine(ATM)HMM predict
3839Phosphotyrosine(Syk)HMM predict
3855Phosphotyrosine(INSR)HMM predict
3863N-linkedHMM predict
3876Phosphoserine(PKG)HMM predict
3891Phosphoserine(PKG)HMM predict
4099Phosphoserine(CK1)HMM predict
4099PhosphoserineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018