AutismKB 2.0

Annotation Detail for ERBB2IP


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Basic Information Top
Gene Symbol:ERBB2IP ( ERBIN,LAP2 )
Gene Full Name: erbb2 interacting protein
Band: 5q12.3
Quick LinksEntrez ID:55914; OMIM: 606944; Uniprot ID:LAP2_HUMAN; ENSEMBL ID: ENSG00000112851; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
440Phosphoserine.
483Phosphotyrosine.
485Phosphothreonine.
487Phosphotyrosine.
569Phosphoserine.
598Phosphoserine.
602Phosphoserine.
603Phosphoserine.
715Phosphoserine (By similarity).
733Phosphotyrosine.
797Phosphoserine.
853Phosphothreonine (By similarity).
857Phosphoserine.
872Phosphoserine.
917Phosphothreonine.
920Phosphotyrosine.
931Phosphoserine.
934Phosphoserine.
972Phosphotyrosine.
981Phosphotyrosine.
1060Phosphoserine.
1104Phosphotyrosine.
1107Phosphotyrosine.
1132Phosphotyrosine.
1158Phosphoserine.
1164Phosphotyrosine.
1179Phosphoserine (By similarity).
1271Phosphoserine.
1286Phosphoserine.
1293Phosphotyrosine.
Location(AA) Modifications Resource
440Phosphoserine.Swiss-Prot 53.0
440PhosphoserinePhospho.ELM 6.0
444PhosphoserinePhospho.ELM 6.0
598Phosphoserine.Swiss-Prot 53.0
598PhosphoserinePhospho.ELM 6.0
602Phosphoserine.Swiss-Prot 53.0
602PhosphoserinePhospho.ELM 6.0
603PhosphoserinePhospho.ELM 6.0
603Phosphoserine.Swiss-Prot 53.0
733PhosphotyrosinePhospho.ELM 6.0
733Phosphotyrosine.Swiss-Prot 53.0
853Phosphothreonine (By similarity).Swiss-Prot 53.0
857Phosphoserine.Swiss-Prot 53.0
857PhosphoserinePhospho.ELM 6.0
917PhosphothreoninePhospho.ELM 6.0
917Phosphothreonine.Swiss-Prot 53.0
920Phosphotyrosine.Swiss-Prot 53.0
920PhosphotyrosinePhospho.ELM 6.0
972Phosphotyrosine.Swiss-Prot 53.0
972PhosphotyrosinePhospho.ELM 6.0
981Phosphotyrosine.Swiss-Prot 53.0
981PhosphotyrosinePhospho.ELM 6.0
1104PhosphotyrosinePhospho.ELM 6.0
1104Phosphotyrosine.Swiss-Prot 53.0
1107PhosphotyrosinePhospho.ELM 6.0
1107Phosphotyrosine.Swiss-Prot 53.0
1132Phosphotyrosine.Swiss-Prot 53.0
1132PhosphotyrosinePhospho.ELM 6.0
1271Phosphoserine.Swiss-Prot 53.0
1271PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
14S-palmitoylHMM predict
139N-linkedHMM predict
234Phosphotyrosine(Jak)HMM predict
277N-linkedHMM predict
346N-linkedHMM predict
359Phosphothreonine(PKC)HMM predict
401N-linkedHMM predict
415Phosphoserine(CK1)HMM predict
446N-linkedHMM predict
536Phosphoserine(IKK)HMM predict
538O-linkedHMM predict
539O-linkedHMM predict
540O-linkedHMM predict
541Phosphothreonine(PKC)HMM predict
552Phosphotyrosine(INSR)HMM predict
569O-linkedHMM predict
598Phosphoserine(CK2)HMM predict
602Phosphoserine(CK2)HMM predict
602Phosphoserine(CK1)HMM predict
603Phosphoserine(CK1)HMM predict
603Phosphoserine(CK2)HMM predict
603Phosphoserine(ATM)HMM predict
603PhosphoserineHMM predict
642Phosphoserine(CK1)HMM predict
644Phosphoserine(ATM)HMM predict
654N-linkedHMM predict
655N-linkedHMM predict
656Phosphoserine(IKK)HMM predict
657N-linkedHMM predict
660Phosphoserine(CDK)HMM predict
660Phosphoserine(CDC2)HMM predict
665Phosphoserine(CK1)HMM predict
669Phosphoserine(IKK)HMM predict
675Phosphoserine(ATM)HMM predict
678O-linkedHMM predict
679Phosphoserine(IKK)HMM predict
682Phosphoserine(MAPK)HMM predict
713N-linkedHMM predict
751O-linkedHMM predict
773N-linkedHMM predict
786Phosphothreonine(PKC)HMM predict
800Phosphoserine(CK1)HMM predict
830Phosphoserine(IKK)HMM predict
830Phosphoserine(ATM)HMM predict
832Phosphoserine(CDC2)HMM predict
832Phosphoserine(CDK)HMM predict
832Phosphoserine(IKK)HMM predict
834N-linkedHMM predict
857Phosphoserine(ATM)HMM predict
898Phosphothreonine(PKC)HMM predict
898O-linkedHMM predict
930Phosphoserine(CK2)HMM predict
934Phosphoserine(CK1)HMM predict
963Phosphoserine(IKK)HMM predict
963O-linkedHMM predict
1015Phosphoserine(PKB)HMM predict
1015Phosphoserine(IKK)HMM predict
1015Phosphoserine(CK1)HMM predict
1015Phosphoserine(PKG)HMM predict
1018N-linkedHMM predict
1021Phosphotyrosine(EGFR)HMM predict
1029N-linkedHMM predict
1032N-linkedHMM predict
1034N-linkedHMM predict
1035N-linkedHMM predict
1078Phosphoserine(IKK)HMM predict
1079PhosphoserineHMM predict
1079Phosphoserine(PKB)HMM predict
1079Phosphoserine(IKK)HMM predict
1081Phosphoserine(CK2)HMM predict
1083O-linkedHMM predict
1094Phosphothreonine(PKC)HMM predict
1116Phosphothreonine(MAPK)HMM predict
1123Phosphoserine(ATM)HMM predict
1133Phosphoserine(CAMK2)HMM predict
1133Phosphoserine(IKK)HMM predict
1133Phosphoserine(PKA)HMM predict
1138N-linkedHMM predict
1144Phosphoserine(IKK)HMM predict
1158Phosphoserine(PKB)HMM predict
1163N-linkedHMM predict
1167Phosphothreonine(PKC)HMM predict
1168Phosphoserine(CDC2)HMM predict
1182Phosphoserine(IKK)HMM predict
1217O-linkedHMM predict
1230Phosphoserine(CDK)HMM predict
1234N-linkedHMM predict
1269N-linkedHMM predict
1271Phosphoserine(ATM)HMM predict
1304Phosphotyrosine(Abl)HMM predict
1310Phosphoserine(ATM)HMM predict
1337Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001006600
  • Location:chr5 65258139-65412605
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65256539 65257126 587 1307
CTCF G2GSE9613 65257468 65258091 623 360
H3K4me3 colorectalcancer 65256208 65256681 473 1695
NRSF mAbJurkat 65257468 65257811 343 500
Oct1 HelaGSE14283 65247144 65247182 38 10977
PHF8 HeLaGSE20725 65256365 65258468 2103 723
hScc1 BcellGSE12603 65256505 65256988 483 1393
hScc1 CdLSGSE12603 65256096 65257126 1030 1529
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 65415101 65415491 390 2691
Oct1 HelaGSE14283 65425646 65425682 36 13059
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 65318589 65318808 219 0
Fos K562GSE19551 65293169 65293750 581 0
FoxA1 MCF7MACSdata 65318466 65318648 182 0
H3K4me3 colorectalcancer 65257537 65259601 2064 0
H3ac HepG2E 65258155 65259876 1721 0
Myc K562GSE19551 65298889 65299280 391 0
Nanog ESGSE20650 65272737 65272933 196 0
Nanog hESGSE18292 65331011 65331347 336 0
Oct1 H2O2-HelaGSE14283 65275513 65275540 27 0
Oct1 H2O2-HelaGSE14283 65325446 65325495 49 0
Oct1 H2O2-HelaGSE14283 65350571 65350603 32 0
Oct1 H2O2-HelaGSE14283 65356860 65356895 35 0
Oct1 HelaGSE14283 65275473 65275540 67 0
Oct1 HelaGSE14283 65315815 65315852 37 0
Oct1 HelaGSE14283 65325448 65325496 48 0
Oct1 HelaGSE14283 65326166 65326202 36 0
Oct1 HelaGSE14283 65350571 65350608 37 0
Oct1 HelaGSE14283 65356803 65356895 92 0
Oct1 HelaGSE14283 65366715 65366750 35 0
TAF HelaGSE8489 65258827 65259950 1123 0
TAF k562GSE8489 65258235 65261188 2953 0
TAF k562GSE8489 65261526 65261870 344 0
hScc1 BcellGSE12603 65258091 65258390 299 0
p130 SenescentGSE19898 65293271 65293612 341 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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