AutismKB 2.0

Annotation Detail for MAPK1


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Basic Information Top
Gene Symbol:MAPK1 ( ERK,ERK2,ERT1,MAPK2,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk )
Gene Full Name: mitogen-activated protein kinase 1
Band: 22q11.22
Quick LinksEntrez ID:5594; OMIM: 176948; Uniprot ID:MK01_HUMAN; ENSEMBL ID: ENSG00000100030; HGNC ID: 6871
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
63Phosphothreonine.
181Phosphothreonine.
185Phosphothreonine.
187TXY.
187Phosphotyrosine.
190Phosphothreonine (By similarity).
202Phosphoserine.
284Phosphoserine.
Location(AA) Modifications Resource
2N-acetylalanine.Swiss-Prot 53.0
184Phosphothreonine (MAP2K1;MAP3K)Phospho.ELM 6.0
185Phosphothreonine.Swiss-Prot 53.0
186Phosphotyrosine (MAP2K1;JAK2;)Phospho.ELM 6.0
187Phosphotyrosine.Swiss-Prot 53.0
190Phosphothreonine (By similarity).Swiss-Prot 53.0
204PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
102Phosphotyrosine(Jak)HMM predict
158N-linkedHMM predict
205Phosphotyrosine(INSR)HMM predict
248Phosphoserine(ATM)HMM predict
312Phosphotyrosine(Syk)HMM predict
316Phosphotyrosine(Syk)HMM predict
316SulfotyrosineHMM predict
316Phosphotyrosine(INSR)HMM predict
317Phosphotyrosine(Syk)HMM predict
317SulfotyrosineHMM predict
358TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002745
  • Location:chr22 20443948-20551969
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 20440984 20441201 217 2856
p130 SenescentGSE19898 20438979 20439321 342 4799
No data
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-146b-3p hsa-mir-146b 10 19786024
hsa-miR-146b-5p hsa-mir-146b 10 19786024
hsa-miR-199a-3p hsa-mir-199a-1 19 18456660
hsa-miR-199a-3p hsa-mir-199a-2 1 18456660
hsa-miR-199a-5p hsa-mir-199a-1 19 18456660
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018