AutismKB 2.0

Annotation Detail for MAPK3


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Basic Information Top
Gene Symbol:MAPK3 ( ERK1,HS44KDAP,HUMKER1A,MGC20180,P44ERK1,P44MAPK,PRKM3 )
Gene Full Name: mitogen-activated protein kinase 3
Band: 16p11.2
Quick LinksEntrez ID:5595; OMIM: 601795; Uniprot ID:MK03_HUMAN; ENSEMBL ID: ENSG00000102882; HGNC ID: 6877
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
170Phosphoserine.
198Phosphothreonine.
202Phosphothreonine.
204TXY.
204Phosphotyrosine.
Location(AA) Modifications Resource
2N-acetylalanine (By similarity).Swiss-Prot 53.0
201Phosphothreonine (MAP2K1;MAP2K)Phospho.ELM 6.0
202Phosphothreonine.Swiss-Prot 53.0
203Phosphotyrosine (MAP2K1;MAP2K)Phospho.ELM 6.0
204Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
53Phosphotyrosine(Abl)HMM predict
53Phosphotyrosine(SRC)HMM predict
66Phosphothreonine(PKC)HMM predict
119Phosphotyrosine(Jak)HMM predict
175N-linkedHMM predict
222Phosphotyrosine(INSR)HMM predict
265Phosphoserine(ATM)HMM predict
329Phosphotyrosine(Syk)HMM predict
333Phosphotyrosine(Syk)HMM predict
334Phosphotyrosine(Syk)HMM predict
334SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002746
  • Location:chr16 30032926-30042130
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 30037747 30037784 37 0
Oct1 H2O2-HelaGSE14283 30037589 30037618 29 0
Oct1 HelaGSE14283 30037589 30037618 29 0
PHF8 HeLaGSE20725 30041443 30042589 1146 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 21057545
hsa-let-7a hsa-let-7a-2 11 21057545
hsa-let-7a hsa-let-7a-3 22 21057545
hsa-let-7a* hsa-let-7a-1 9 21057545
hsa-let-7a* hsa-let-7a-3 22 21057545
hsa-let-7b hsa-let-7b 22 21057545
hsa-let-7b* hsa-let-7b 22 21057545
hsa-let-7c hsa-let-7c 21 21057545
hsa-let-7c* hsa-let-7c 21 21057545
hsa-let-7d hsa-let-7d 9 21057545
hsa-let-7d* hsa-let-7d 9 21057545
hsa-let-7e hsa-let-7e 19 21057545
hsa-let-7e* hsa-let-7e 19 21057545
hsa-let-7f hsa-let-7f-1 9 21057545
hsa-let-7f hsa-let-7f-2 X 21057545
hsa-let-7f-1* hsa-let-7f-1 9 21057545
hsa-let-7f-2* hsa-let-7f-2 X 21057545
hsa-let-7g hsa-let-7g 3 21057545
hsa-let-7g* hsa-let-7g 3 21057545
hsa-let-7i hsa-let-7i 12 21057545
hsa-let-7i* hsa-let-7i 12 21057545
hsa-miR-125a-3p hsa-mir-125a 19 21060679
hsa-miR-125a-5p hsa-mir-125a 19 21060679
hsa-miR-125b hsa-mir-125b-1 11 21060679
hsa-miR-125b hsa-mir-125b-2 21 21060679
hsa-miR-125b-1* hsa-mir-125b-1 11 21060679
hsa-miR-125b-2* hsa-mir-125b-2 21 21060679
hsa-miR-132 hsa-mir-132 17 20307261
hsa-miR-132 hsa-mir-132 17 19958814
hsa-miR-132* hsa-mir-132 17 20307261
hsa-miR-132* hsa-mir-132 17 19958814
hsa-miR-143 hsa-mir-143 5 19137007
hsa-miR-143* hsa-mir-143 5 19137007
hsa-miR-146a hsa-mir-146a 5 21060679
hsa-miR-146a* hsa-mir-146a 5 21060679
hsa-miR-146b-3p hsa-mir-146b 10 21060679
hsa-miR-146b-5p hsa-mir-146b 10 21060679
hsa-miR-155 hsa-mir-155 21 21060679
hsa-miR-155 hsa-mir-155 21 20735984
hsa-miR-155 hsa-mir-155 21 19109256
hsa-miR-155 hsa-mir-155 21 17588946
hsa-miR-155 hsa-mir-155 21 16675453
hsa-miR-155* hsa-mir-155 21 21060679
hsa-miR-155* hsa-mir-155 21 20735984
hsa-miR-155* hsa-mir-155 21 19109256
hsa-miR-155* hsa-mir-155 21 17588946
hsa-miR-155* hsa-mir-155 21 16675453
hsa-miR-15a hsa-mir-15a 13 20660113
hsa-miR-15a hsa-mir-15a 13 20634433
hsa-miR-15a hsa-mir-15a 13 19109256
hsa-miR-15a* hsa-mir-15a 13 20660113
hsa-miR-15a* hsa-mir-15a 13 20634433
hsa-miR-15a* hsa-mir-15a 13 19109256
hsa-miR-15b hsa-mir-15b 3 20660113
hsa-miR-15b* hsa-mir-15b 3 20660113
hsa-miR-181a hsa-mir-181a-2 9 20884876
hsa-miR-181a hsa-mir-181a-1 1 20884876
hsa-miR-205 hsa-mir-205 1 21330408
hsa-miR-21 hsa-mir-21 17 20884876
hsa-miR-21 hsa-mir-21 17 20498256
hsa-miR-21 hsa-mir-21 17 19419954
hsa-miR-21* hsa-mir-21 17 20884876
hsa-miR-21* hsa-mir-21 17 20498256
hsa-miR-21* hsa-mir-21 17 19419954
hsa-miR-212 hsa-mir-212 17 20307261
hsa-miR-221 hsa-mir-221 X 19438724
hsa-miR-221* hsa-mir-221 X 19438724
hsa-miR-222 hsa-mir-222 X 19438724
hsa-miR-222* hsa-mir-222 X 19438724
hsa-miR-375 hsa-mir-375 2 21291493
hsa-miR-455-3p hsa-mir-455 9 21060679
hsa-miR-455-5p hsa-mir-455 9 21060679
hsa-miR-9 hsa-mir-9-1 1 19958814
hsa-miR-9 hsa-mir-9-2 5 19958814
hsa-miR-9 hsa-mir-9-3 15 19958814
hsa-miR-9 hsa-mir-9-1 1 19137007
hsa-miR-9 hsa-mir-9-2 5 19137007
hsa-miR-9 hsa-mir-9-3 15 19137007
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018