AutismKB 2.0

Annotation Detail for MAPK4


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Basic Information Top
Gene Symbol:MAPK4 ( ERK3,Erk4,PRKM4,p63MAPK )
Gene Full Name: mitogen-activated protein kinase 4
Band: 18q21.1-q21.2
Quick LinksEntrez ID:5596; OMIM: 176949; Uniprot ID:MK04_HUMAN; ENSEMBL ID: ENSG00000141639; HGNC ID: 6878
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
186Phosphoserine.
Location(AA) Modifications Resource
196Phosphoserine (MAPK4)Phospho.ELM 6.0
Location(AA) Modification Resource
184Phosphotyrosine(Syk)HMM predict
205N-linkedHMM predict
206Phosphotyrosine(INSR)HMM predict
311Phosphotyrosine(Syk)HMM predict
311Phosphotyrosine(INSR)HMM predict
316Phosphoserine(IKK)HMM predict
324Phosphoserine(ATM)HMM predict
343N-linkedHMM predict
345Phosphoserine(IKK)HMM predict
345Phosphoserine(ATM)HMM predict
349N-linkedHMM predict
350C-linkedHMM predict
362Phosphoserine(CK2)HMM predict
363Phosphoserine(CK1)HMM predict
400Phosphoserine(PKA)HMM predict
400Phosphoserine(PKG)HMM predict
400Phosphoserine(IKK)HMM predict
402Phosphoserine(CK1)HMM predict
450Phosphotyrosine(INSR)HMM predict
473O-linkedHMM predict
499PhosphothreonineHMM predict
505Phosphothreonine(CDC2)HMM predict
505Phosphothreonine(CDK)HMM predict
512O-linkedHMM predict
514O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002747
  • Location:chr18 46340481-46512192
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 46330867 46330900 33 9598
STAT1 HeLaGSE12783 46325035 46325788 753 15070
STAT1 IFNSISSRdata 46325042 46325751 709 15085
hScc1 BcellGSE12603 46339720 46340750 1030 247
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 46513881 46513913 32 1705
Oct1 H2O2-HelaGSE14283 46515930 46515970 40 3758
Oct1 HelaGSE14283 46513878 46513914 36 1704
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 46510133 46510345 212 0
Nanog hESGSE18292 46376265 46376440 175 0
Nanog hESGSE18292 46486796 46487197 401 0
Oct1 H2O2-HelaGSE14283 46507813 46507845 32 0
Oct1 HelaGSE14283 46455010 46455091 81 0
Oct1 HelaGSE14283 46475256 46475292 36 0
RARA MCF7GSE15244 46391354 46392260 906 0
Stat6 IL-4-hr1GSE17850 46467753 46468171 418 0
TFAP2C MCF7GSE21234 46391841 46392425 584 0
TFAP2C MCF7GSE21234 46502723 46503060 337 0
hScc1 BcellGSE12603 46429881 46430505 624 0
hScc1 BcellGSE12603 46509821 46510269 448 0
Validated miRNA targets Top
Cis-Nats regulation Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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