Annotation Detail for MAP2K1

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Basic Information Top

Gene Symbol:	MAP2K1 ( MAPKK1,MEK1,MKK1,PRKMK1 )
Gene Full Name:	mitogen-activated protein kinase kinase 1
Band:	15q22.31
Quick Links	Entrez ID:5604; OMIM: 176872; Uniprot ID:MP2K1_HUMAN; ENSEMBL ID: ENSG00000169032; HGNC ID: 6840
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T30-glioblastoma	GSE21026	64465677	64466616	939	532
CTCF	CD4	GSE12889	64465991	64466313	322	527
CTCF	CD4	SISSRdata	64465991	64466313	322	527
CTCF	G2	GSE9613	64465828	64466317	489	606
ETS1	Jurkat	GSE17954	64465758	64466479	721	560
Fos	K562	GSE19551	64465858	64466469	611	515
H3ac	HepG2	E	64465723	64465983	260	826
Myc	K562	GSE19551	64465841	64466476	635	520
PHF8	HeLa	GSE20725	64465535	64467059	1524	382
Rb	Growing	GSE19898	64465990	64466208	218	580
Rb	Senescent	GSE19898	64465931	64466555	624	436
TFAP2C	MCF7	GSE21234	64465803	64466471	668	542
USF1	HepG2	E	64465723	64465893	170	871
hScc1	Bcell	GSE12603	64465761	64466927	1166	335
p130	Quiescent	GSE19898	64466351	64466466	115	270
p130	shRbSenescent	GSE19898	64466023	64466289	266	523
p130	shRbSenescent	GSE19898	64466380	64466518	138	230

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	64542022	64542364	342
ETS1	Jurkat	GSE17954	64466511	64467170	659
ETS1	Jurkat	GSE17954	64514185	64515004	819
ETS1	Jurkat	GSE17954	64516017	64516406	389
ETS1	Jurkat	GSE17954	64560940	64561393	453
ETS1	Jurkat	GSE17954	64564050	64564702	652
FoxA1	MCF7	MACSdata	64478606	64478866	260
H3ac	HepG2	E	64466781	64467522	741
Nanog	hES	GSE18292	64553604	64553860	256
Oct1	Hela	GSE14283	64501346	64501379	33
Rb	Quiescent	GSE19898	64466941	64467167	226
Rb	Senescent	GSE19898	64466951	64467278	327
TAF	Hela	GSE8489	64539589	64539981	392
p130	shRbSenescent	GSE19898	64466629	64467045	416

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-146b-3p	hsa-mir-146b	10	19786024
hsa-miR-146b-5p	hsa-mir-146b	10	19786024
hsa-miR-205	hsa-mir-205	1	20065103
hsa-miR-221	hsa-mir-221	X	20299489
hsa-miR-221*	hsa-mir-221	X	20299489
hsa-miR-222	hsa-mir-222	X	20299489
hsa-miR-222*	hsa-mir-222	X	20299489
hsa-miR-224	hsa-mir-224	X	20065103
hsa-miR-335	hsa-mir-335	7	20065103
hsa-miR-335*	hsa-mir-335	7	20065103
hsa-miR-34a	hsa-mir-34a	1	20299489
hsa-miR-34a*	hsa-mir-34a	1	20299489
hsa-miR-424	hsa-mir-424	X	21179471
hsa-miR-424	hsa-mir-424	X	20065103
hsa-miR-424*	hsa-mir-424	X	21179471
hsa-miR-424*	hsa-mir-424	X	20065103
hsa-miR-451	hsa-mir-451	17	20065103
hsa-miR-491-3p	hsa-mir-491	9	20065103
hsa-miR-491-5p	hsa-mir-491	9	20065103
hsa-miR-93	hsa-mir-93	7	20065103
hsa-miR-93*	hsa-mir-93	7	20065103

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
8969	mRNA	MAP2K1	chr15	64466678	64570935	229	mRNA		chr15	64569142	64571460	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018