AutismKB 2.0

Annotation Detail for MAP2K2


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Basic Information Top
Gene Symbol:MAP2K2 ( FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2 )
Gene Full Name: mitogen-activated protein kinase kinase 2
Band: 19p13.3
Quick LinksEntrez ID:5605; OMIM: 601263; Uniprot ID:MP2K2_HUMAN; ENSEMBL ID: ENSG00000126934; HGNC ID: 6842
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
23Phosphoserine.
222Phosphoserine; by RAF; alternate.
222O-acetylserine; by Yersinia yopJ;
226O-acetylserine; by Yersinia yopJ;
226Phosphoserine; alternate.
293Phosphoserine.
295Phosphoserine.
394Phosphothreonine.
396Phosphothreonine.
Location(AA) Modifications Resource
23Phosphoserine.Swiss-Prot 53.0
23PhosphoserinePhospho.ELM 6.0
216PhosphoserinePhospho.ELM 6.0
222Phosphoserine (by RAF) (By similarity).Swiss-Prot 53.0
222Phosphoserine (MAP3K8)Phospho.ELM 6.0
226Phosphoserine.Swiss-Prot 53.0
226Phosphoserine (MAP3K8;PDK-1)Phospho.ELM 6.0
394Phosphothreonine.Swiss-Prot 53.0
394PhosphothreoninePhospho.ELM 6.0
396Phosphothreonine.Swiss-Prot 53.0
Location(AA) Modification Resource
15N-linkedHMM predict
17O-linkedHMM predict
23Phosphoserine(CDC2)HMM predict
26Phosphoserine(IKK)HMM predict
26O-linkedHMM predict
26O-linkedHMM predict
174Phosphoserine(PKG)HMM predict
295Phosphoserine(CDC2)HMM predict
295O-linkedHMM predict
297MethylarginineHMM predict
306Phosphoserine(IKK)HMM predict
324Phosphotyrosine(INSR)HMM predict
365N-linkedHMM predict
387LeucineHMM predict
394Phosphothreonine(CDC2)HMM predict
394Phosphothreonine(MAPK)HMM predict
394Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_030662
  • Location:chr19 4041328-4075125
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 4085574 4085648 74 10486
Myc K562GSE19551 4081958 4082487 529 7097
P300 T30-glioblastomaGSE21026 4074698 4075556 858 2
P300 T30-glioblastomaGSE21026 4081730 4082587 857 7033
Rb SenescentGSE19898 4075058 4075450 392 129
TAFII hESGSE17917 4074859 4075465 606 37
USF1 HepG2E 4081809 4082086 277 6822
p130 QuiescentGSE19898 4075333 4075529 196 306
p130 SenescentGSE19898 4075231 4075566 335 273
p130 shRbSenescentGSE19898 4075071 4075477 406 149
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 4039186 4039590 404 1941
FoxA1 MCF7MACSdata 4037557 4037794 237 3653
TFAP2C MCF7GSE21234 4034963 4035973 1010 5861
TFAP2C MCF7GSE21234 4037297 4037909 612 3726
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 4055179 4056837 1658 0
CBP JurkatGSE17954 4059088 4060762 1674 0
CTCF CD4GSE12889 4066144 4066273 129 0
CTCF CD4SISSRdata 4066144 4066273 129 0
CTCF G2GSE9613 4063248 4063711 463 0
ETS1 JurkatGSE17954 4059477 4060679 1202 0
H3ac HepG2E 4073481 4074523 1042 0
Oct1 HelaGSE14283 4051677 4051705 28 0
Oct1 HelaGSE14283 4052701 4052736 35 0
PHF8 HeLaGSE20725 4074617 4075609 992 0
hScc1 BcellGSE12603 4049444 4049633 189 0
hScc1 BcellGSE12603 4063406 4063783 377 0
hScc1 BcellGSE12603 4066009 4066855 846 0
hScc1 BcellGSE12603 4068389 4068596 207 0
p63 keratinocytesGSE17611 4055803 4056455 652 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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