AutismKB 2.0

Annotation Detail for MAP2K6


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Basic Information Top
Gene Symbol:MAP2K6 ( MAPKK6,MEK6,MKK6,PRKMK6,SAPKK3 )
Gene Full Name: mitogen-activated protein kinase kinase 6
Band: 17q24.3
Quick LinksEntrez ID:5608; OMIM: 601254; Uniprot ID:MP2K6_HUMAN; ENSEMBL ID: ENSG00000108984; HGNC ID: 6846
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
27Phosphoserine.
28Phosphothreonine.
82N6-acetyllysine.
207O-acetylserine; by Yersinia yopJ;
207Phosphoserine; alternate.
211O-acetylthreonine; by Yersinia yopJ;
211Phosphothreonine; alternate.
Location(AA) Modifications Resource
207O-acetylserine; by Yersinia yopJ;alternate.Swiss-Prot 53.0
207Phosphoserine; alternate.Swiss-Prot 53.0
207PhosphoserinePhospho.ELM 6.0
211O-acetylthreonine; by Yersinia yopJ;alternate.Swiss-Prot 53.0
211Phosphothreonine; alternate.Swiss-Prot 53.0
211PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
26O-linkedHMM predict
28Phosphothreonine(CDC2)HMM predict
28Phosphothreonine(MAPK)HMM predict
28Phosphothreonine(CDK)HMM predict
64Phosphotyrosine(SRC)HMM predict
171Phosphoserine(CK1)HMM predict
304Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002758
  • Location:chr17 64922432-65050056
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 64902541 64902733 192 19796
CTCF CD4SISSRdata 64902541 64902733 192 19796
CTCF G2GSE9613 64902576 64902899 323 19695
ER E2-MCF7GSE14664 64902795 64902863 68 19604
ETS1 JurkatGSE17954 64921811 64923050 1239 2
H3ac HepG2E 64922052 64922268 216 273
Oct1 HelaGSE14283 64916286 64916314 28 6133
P300 T30-glioblastomaGSE21026 64922101 64922692 591 36
PHF8 293TGSE20725 64921811 64922854 1043 100
RNAII Tamoxifen-MCF7GSE14664 64902801 64902869 68 19598
RNAII Tamoxifen-MCF7GSE14664 64903938 64904016 78 18456
RNAII Tamoxifen-MCF7GSE14664 64906632 64906725 93 15754
hScc1 BcellGSE12603 64902576 64902743 167 19773
hScc1 CdLSGSE12603 64902576 64902899 323 19695
hScc1 G2GSE9613 64902576 64902899 323 19695
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RARG MCF7GSE15244 65068755 65069421 666 19032
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65031069 65031530 461 0
CTCF G2GSE9613 65033639 65034399 760 0
Myc hESGSE17917 65008867 65009227 360 0
Nanog hESGSE18292 64933838 64934294 456 0
Nanog hESGSE18292 64957930 64958145 215 0
Nanog hESGSE18292 64969147 64969618 471 0
Oct1 HelaGSE14283 64930012 64930045 33 0
Oct1 HelaGSE14283 64930852 64930887 35 0
Oct1 HelaGSE14283 64932732 64932798 66 0
Oct1 HelaGSE14283 65008830 65008912 82 0
Rb GrowingGSE19898 64978332 64978502 170 0
hScc1 BcellGSE12603 65030884 65031494 610 0
hScc1 BcellGSE12603 65033601 65034183 582 0
hScc1 CdLSGSE12603 65030841 65031530 689 0
hScc1 CdLSGSE12603 65033565 65034254 689 0
hScc1 G2GSE9613 65031027 65031530 503 0
hScc1 G2GSE9613 65033710 65034435 725 0
p130 shRbQuiescentGSE19898 65009330 65010265 935 0
p63 keratinocytesGSE17611 64937905 64938795 890 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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