Annotation Detail for EIF2AK2
Basic Information Top
| Gene Symbol: | EIF2AK2 ( EIF2AK1,MGC126524,PKR,PRKR ) |
|---|---|
| Gene Full Name: | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Band: | 2p22.2 |
| Quick Links | Entrez ID:5610; OMIM: 176871; Uniprot ID:E2AK2_HUMAN; ENSEMBL ID: ENSG00000055332; HGNC ID: 9437 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 2 | N-acetylalanine. | |
| 83 | Phosphoserine; by autocatalysis | |
| 88 | Phosphothreonine; by autocatalysis | |
| 89 | Phosphothreonine; by autocatalysis | |
| 90 | Phosphothreonine; by autocatalysis | |
| 242 | Phosphoserine; by autocatalysis | |
| 255 | Phosphothreonine; by autocatalysis | |
| 258 | Phosphothreonine; by autocatalysis | |
| 446 | Phosphothreonine; by autocatalysis. | |
| 451 | Phosphothreonine; by autocatalysis. | |
| 456 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 83 | Phosphoserine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 83 | Phosphoserine (EIF2AK2) | Phospho.ELM 6.0 |
| 88 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 88 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 89 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 89 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 90 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 90 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 101 | Phosphotyrosine | Phospho.ELM 6.0 |
| 162 | Phosphotyrosine | Phospho.ELM 6.0 |
| 242 | Phosphoserine (EIF2AK2) | Phospho.ELM 6.0 |
| 242 | Phosphoserine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 255 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 255 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 258 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 |
| 258 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 293 | Phosphotyrosine | Phospho.ELM 6.0 |
| 446 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 |
| 446 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| 451 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 |
| 451 | Phosphothreonine (EIF2AK2) | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 16 | Phosphothreonine(PKC) | HMM predict |
| 33 | Phosphoserine(ATM) | HMM predict |
| 101 | Phosphotyrosine(INSR) | HMM predict |
| 171 | Phosphoserine(CK1) | HMM predict |
| 174 | Phosphoserine(PKA) | HMM predict |
| 181 | Phosphoserine(IKK) | HMM predict |
| 184 | O-linked | HMM predict |
| 188 | Phosphoserine(IKK) | HMM predict |
| 190 | O-linked | HMM predict |
| 192 | Phosphoserine(IKK) | HMM predict |
| 203 | Phosphoserine(CK1) | HMM predict |
| 221 | Phosphoserine(CK1) | HMM predict |
| 221 | Phosphoserine(IKK) | HMM predict |
| 221 | O-linked | HMM predict |
| 242 | Phosphoserine(PKG) | HMM predict |
| 337 | Phosphoserine(CK1) | HMM predict |
| 340 | Phosphoserine(IKK) | HMM predict |
| 344 | Phosphoserine(ATM) | HMM predict |
| 344 | Phosphoserine(CK1) | HMM predict |
| 346 | Phosphotyrosine(INSR) | HMM predict |
| 346 | Phosphotyrosine(Syk) | HMM predict |
| 351 | Phosphoserine(CK1) | HMM predict |
| 353 | N-linked | HMM predict |
| 404 | Phosphotyrosine(Jak) | HMM predict |
| 446 | Phosphothreonine(PKC) | HMM predict |
| 448 | Phosphoserine(CAMK2) | HMM predict |
| 454 | Phosphotyrosine(INSR) | HMM predict |
| 462 | Phosphoserine(ATM) | HMM predict |
| 465 | Phosphotyrosine(INSR) | HMM predict |
| 542 | Phosphoserine(CDC2) | HMM predict |
| 545 | Lysine | HMM predict |
- RefSeq ID: NM_002759
- Location:chr2 37187202-37229906
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | G2 | GSE9613 | 37237390 | 37237782 | 392 | 7680 |
| H3K4me3 | colorectal | cancer | 37236351 | 37237356 | 1005 | 6947 |
| H3ac | HepG2 | E | 37235750 | 37237356 | 1606 | 6647 |
| H3ac | HepG2 | E | 37238117 | 37238323 | 206 | 8314 |
| PHF8 | Hs68minusFBS | GSE20725 | 37236677 | 37238211 | 1534 | 7538 |
| hScc1 | Bcell | GSE12603 | 37237356 | 37237708 | 352 | 7626 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| FoxA1 | MCF7 | MACSdata | 37184293 | 37184579 | 286 | 2767 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| FOXA1 | MCF7 | GSE15244 | 37229053 | 37229842 | 789 | 0 |
| Oct1 | H2O2-Hela | GSE14283 | 37190871 | 37190905 | 34 | 0 |
| Oct1 | Hela | GSE14283 | 37190871 | 37190903 | 32 | 0 |
| Oct1 | Hela | GSE14283 | 37229243 | 37229274 | 31 | 0 |
| RNAII | Tamoxifen-MCF7 | GSE14664 | 37192902 | 37192981 | 79 | 0 |
| p63 | keratinocytes | GSE17611 | 37191158 | 37191953 | 795 | 0 |
Validated miRNA targets