AutismKB 2.0

Annotation Detail for PRLR


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Basic Information Top
Gene Symbol:PRLR ( hPRLrI )
Gene Full Name: prolactin receptor
Band: 5p13.2
Quick LinksEntrez ID:5618; OMIM: 176761; Uniprot ID:PRLR_HUMAN; ENSEMBL ID: ENSG00000113494; HGNC ID: 9446
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
59N-linked (GlcNAc...) (Potential).
104N-linked (GlcNAc...) (Potential).
219WSXWS motif.
233N-linked (GlcNAc...) (Potential).
275Box 1 motif.
Location(AA) Modifications Resource
59N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
104N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
233N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
349PhosphoserinePhospho.ELM 6.0
415PhosphothreoninePhospho.ELM 6.0
611PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
38Phosphoserine(CDK)HMM predict
38Phosphoserine(CDC2)HMM predict
59N-linkedHMM predict
104N-linkedHMM predict
107N-linkedHMM predict
118PhosphotyrosineHMM predict
118Phosphotyrosine(Syk)HMM predict
215C-linkedHMM predict
233N-linkedHMM predict
307Phosphotyrosine(Syk)HMM predict
320Phosphoserine(CK1)HMM predict
335Phosphoserine(ATM)HMM predict
342Phosphotyrosine(Jak)HMM predict
349Phosphoserine(IKK)HMM predict
353Phosphoserine(IKK)HMM predict
356Phosphoserine(IKK)HMM predict
358O-linkedHMM predict
370N-linkedHMM predict
432N-linkedHMM predict
462Phosphoserine(ATM)HMM predict
464Phosphothreonine(PKC)HMM predict
484Phosphoserine(CK1)HMM predict
484Phosphoserine(IKK)HMM predict
509Phosphotyrosine(INSR)HMM predict
539Phosphothreonine(CDK)HMM predict
539Phosphothreonine(MAPK)HMM predict
539Phosphothreonine(CDC2)HMM predict
546Phosphotyrosine(INSR)HMM predict
546Phosphotyrosine(Syk)HMM predict
582Phosphoserine(IKK)HMM predict
594N-linkedHMM predict
611Phosphotyrosine(INSR)HMM predict
620SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000949
  • Location:chr5 35099984-35266333
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 35268927 35268954 27 2607
RNAII Tamoxifen-MCF7GSE14664 35276529 35276620 91 10241
TFAP2C MCF7GSE21234 35266131 35266784 653 124
TFAP2C MCF7GSE21234 35282091 35282781 690 16103
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35125508 35125881 373 0
CTCF CD4SISSRdata 35125508 35125881 373 0
CTCF JurkatGSE12889 35125518 35125923 405 0
CTCF G2GSE9613 35125273 35126189 916 0
CTCF G2GSE9613 35180847 35181095 248 0
CTCF G2GSE9613 35238182 35238471 289 0
CTCF G2GSE9613 35265147 35265500 353 0
CTCF G2GSE9613 35265797 35266164 367 0
ER MCF7GSE19013 35241385 35242062 677 0
FOXA1 MCF7GSE15244 35223672 35224610 938 0
FOXA1 MCF7GSE15244 35233824 35234383 559 0
FOXA1 MCF7GSE15244 35249621 35250327 706 0
FoxA1 MCF7MACSdata 35250077 35250288 211 0
Oct1 H2O2-HelaGSE14283 35132262 35132290 28 0
Oct1 HelaGSE14283 35100638 35100676 38 0
Oct1 HelaGSE14283 35184401 35184452 51 0
RARA MCF7GSE15244 35223672 35224610 938 0
RARA MCF7GSE15244 35249293 35250327 1034 0
Stat6 IL-4-hr1GSE17850 35125308 35126029 721 0
TFAP2C MCF7GSE21234 35249361 35250485 1124 0
USF1 HepG2E 35230946 35232565 1619 0
USF1 HepG2E 35257711 35257843 132 0
USF2 HepG2E 35230946 35231432 486 0
hScc1 BcellGSE12603 35125195 35126189 994 0
hScc1 BcellGSE12603 35238182 35238471 289 0
hScc1 BcellGSE12603 35265147 35266164 1017 0
hScc1 CdLSGSE12603 35125273 35126160 887 0
hScc1 G2GSE9613 35125344 35126189 845 0
hScc1 G2GSE9613 35238182 35238398 216 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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