AutismKB 2.0

Annotation Detail for PROC


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Basic Information Top
Gene Symbol:PROC ( APC,PC,PROC1 )
Gene Full Name: protein C (inactivator of coagulation factors Va and VIIIa)
Band: 2q14.3
Quick LinksEntrez ID:5624; OMIM: 612283; Uniprot ID:PROC_HUMAN; ENSEMBL ID: ENSG00000115718; HGNC ID: 9451
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
484-carboxyglutamate.
494-carboxyglutamate.
564-carboxyglutamate.
584-carboxyglutamate.
614-carboxyglutamate.
624-carboxyglutamate.
674-carboxyglutamate.
684-carboxyglutamate.
714-carboxyglutamate.
113(3R)-3-hydroxyaspartate.
139N-linked (GlcNAc...).
290N-linked (GlcNAc...).
355N-linked (GlcNAc...).
371N-linked (GlcNAc...); partial; atypical.
Location(AA) Modifications Resource
484-carboxyglutamate.Swiss-Prot 53.0
494-carboxyglutamate.Swiss-Prot 53.0
564-carboxyglutamate.Swiss-Prot 53.0
584-carboxyglutamate.Swiss-Prot 53.0
614-carboxyglutamate.Swiss-Prot 53.0
624-carboxyglutamate.Swiss-Prot 53.0
674-carboxyglutamate.Swiss-Prot 53.0
684-carboxyglutamate.Swiss-Prot 53.0
714-carboxyglutamate.Swiss-Prot 53.0
1133-hydroxyaspartate.Swiss-Prot 53.0
139N-linked (GlcNAc...).Swiss-Prot 53.0
290N-linked (GlcNAc...).Swiss-Prot 53.0
355N-linked (GlcNAc...).Swiss-Prot 53.0
371N-linked (GlcNAc...); partial; atypical.Swiss-Prot 53.0
Location(AA) Modification Resource
17O-linkedHMM predict
28Phosphoserine(CK1)HMM predict
29Phosphoserine(CDK)HMM predict
45Phosphoserine(PKG)HMM predict
183S-palmitoylHMM predict
201Phosphothreonine(PKA)HMM predict
201Phosphothreonine(CK2)HMM predict
290N-linkedHMM predict
355N-linkedHMM predict
361N-linkedHMM predict
461ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000312
  • Location:chr2 127892486-127903285
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 127881431 127883031 1600 10256
CTCF CD4GSE12889 127889948 127890345 397 2340
CTCF CD4SISSRdata 127889948 127890345 397 2340
CTCF G2GSE9613 127872326 127872713 387 19967
CTCF G2GSE9613 127874693 127875478 785 17401
CTCF G2GSE9613 127882318 127882579 261 10038
CTCF G2GSE9613 127890041 127890396 355 2268
Fos K562GSE19551 127881889 127882450 561 10317
H3ac HepG2E 127888853 127889305 452 3408
H3ac HepG2E 127890695 127893219 2524 530
Oct4 hESGSE17917 127874982 127875265 283 17363
P300 T0-glioblastomaGSE21026 127872168 127872944 776 19931
Rb QuiescentGSE19898 127882017 127882190 173 10383
Rb SenescentGSE19898 127881829 127882339 510 10403
Rb shRbSenescenceGSE19898 127881913 127882300 387 10380
SRF HelaGSE8489 127878717 127878896 179 13680
TAF HelaGSE8489 127878717 127878896 179 13680
TFAP2C MCF7GSE21234 127875445 127876050 605 16739
TFAP2C MCF7GSE21234 127881606 127882203 597 10582
USF1 HepG2E 127885551 127886578 1027 6422
hScc1 BcellGSE12603 127874730 127875478 748 17383
hScc1 BcellGSE12603 127889752 127890292 540 2465
hScc1 G2GSE9613 127874693 127875478 785 17401
p130 shRbQuiescentGSE19898 127882378 127882946 568 9825
p130 shRbSenescentGSE19898 127882490 127882636 146 9924
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 127905686 127905896 210 2506
Oct1 HelaGSE14283 127915452 127915482 30 12182
USF1 HepG2E 127910272 127910620 348 7161
USF1 HepG2E 127911185 127912945 1760 8780
USF2 HepG2E 127912176 127912945 769 9275
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 127892623 127892910 287 0
CTCF G2GSE9613 127893612 127893858 246 0
CTCF G2GSE9613 127896012 127897168 1156 0
CTCF G2GSE9613 127899125 127899384 259 0
CTCF G2GSE9613 127899977 127900228 251 0
CTCF G2GSE9613 127902217 127902617 400 0
ER E2-MCF7GSE14664 127895636 127895732 96 0
H3ac HepG2E 127893612 127895616 2004 0
Nanog hESGSE18292 127899302 127899729 427 0
Oct1 H2O2-HelaGSE14283 127894392 127894421 29 0
Oct1 HelaGSE14283 127894379 127894420 41 0
Sox2 hESGSE18292 127899482 127899736 254 0
USF1 HepG2E 127892763 127893219 456 0
hScc1 BcellGSE12603 127894178 127894393 215 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 19136465
hsa-miR-1 hsa-mir-1-1 20 19136465
hsa-miR-1 hsa-mir-1-2 18 19136465
hsa-miR-1 hsa-mir-1-1 20 19136465
hsa-miR-1 hsa-mir-1-2 18 19136465
hsa-miR-1 hsa-mir-1-1 20 19136465
hsa-miR-133a hsa-mir-133a-1 18 19136465
hsa-miR-133a hsa-mir-133a-2 20 19136465
hsa-miR-133a hsa-mir-133a-1 18 19136465
hsa-miR-133a hsa-mir-133a-2 20 19136465
hsa-miR-133a hsa-mir-133a-1 18 19136465
hsa-miR-133a hsa-mir-133a-2 20 19136465
hsa-miR-133b hsa-mir-133b 6 19136465
hsa-miR-133b hsa-mir-133b 6 19136465
hsa-miR-133b hsa-mir-133b 6 19136465
hsa-miR-135a hsa-mir-135a-1 3 18632633
hsa-miR-135a hsa-mir-135a-2 12 18632633
hsa-miR-135a hsa-mir-135a-1 3 18632633
hsa-miR-135a hsa-mir-135a-2 12 18632633
hsa-miR-135a hsa-mir-135a-1 3 18632633
hsa-miR-135a hsa-mir-135a-2 12 18632633
hsa-miR-135a* hsa-mir-135a-1 3 18632633
hsa-miR-135a* hsa-mir-135a-1 3 18632633
hsa-miR-135a* hsa-mir-135a-1 3 18632633
hsa-miR-135b hsa-mir-135b 1 18632633
hsa-miR-135b hsa-mir-135b 1 18632633
hsa-miR-135b hsa-mir-135b 1 18632633
hsa-miR-135b* hsa-mir-135b 1 18632633
hsa-miR-135b* hsa-mir-135b 1 18632633
hsa-miR-135b* hsa-mir-135b 1 18632633
hsa-miR-155 hsa-mir-155 21 19136465
hsa-miR-155 hsa-mir-155 21 19136465
hsa-miR-155 hsa-mir-155 21 19136465
hsa-miR-155* hsa-mir-155 21 19136465
hsa-miR-155* hsa-mir-155 21 19136465
hsa-miR-155* hsa-mir-155 21 19136465
hsa-miR-17 hsa-mir-17 13 19136465
hsa-miR-17 hsa-mir-17 13 19136465
hsa-miR-17 hsa-mir-17 13 19136465
hsa-miR-17* hsa-mir-17 13 19136465
hsa-miR-17* hsa-mir-17 13 19136465
hsa-miR-17* hsa-mir-17 13 19136465
hsa-miR-21 hsa-mir-21 17 19136465
hsa-miR-21 hsa-mir-21 17 19136465
hsa-miR-21 hsa-mir-21 17 19136465
hsa-miR-21* hsa-mir-21 17 19136465
hsa-miR-21* hsa-mir-21 17 19136465
hsa-miR-21* hsa-mir-21 17 19136465
hsa-miR-210 hsa-mir-210 11 19826008
hsa-miR-210 hsa-mir-210 11 19826008
hsa-miR-210 hsa-mir-210 11 19826008
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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