AutismKB 2.0

Annotation Detail for LGMN


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Basic Information Top
Gene Symbol:LGMN ( AEP,LGMN1,PRSC1 )
Gene Full Name: legumain
Band: 14q32.12
Quick LinksEntrez ID:5641; OMIM: 602620; Uniprot ID:LGMN_HUMAN; ENSEMBL ID: ENSG00000100600; HGNC ID: 9472
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
91N-linked (GlcNAc...).
167N-linked (GlcNAc...).
263N-linked (GlcNAc...) (Potential).
272N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
91N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
167N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
263N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
272N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
80N-linkedHMM predict
91N-linkedHMM predict
96Phosphotyrosine(Syk)HMM predict
109Phosphothreonine(MAPK)HMM predict
167N-linkedHMM predict
221SulfotyrosineHMM predict
272N-linkedHMM predict
291PhosphoserineHMM predict
291Phosphoserine(PKG)HMM predict
291Phosphoserine(PKA)HMM predict
292Phosphoserine(CDC2)HMM predict
292Phosphoserine(CDK)HMM predict
292PhosphoserineHMM predict
307Phosphoserine(CDC2)HMM predict
307Phosphoserine(ATM)HMM predict
307Phosphoserine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001008530
  • Location:chr14 92239909-92284764
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
VDR GM10855-stimGSE22484 92294842 92297020 2178 11167
VDR GM10861-stimGSE22484 92294644 92296687 2043 10901
hScc1 BcellGSE12603 92304624 92304837 213 19966
hScc1 CdLSGSE12603 92304411 92304837 426 19860
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 92238524 92238705 181 1295
RARG MCF7GSE15244 92238524 92238705 181 1295
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 92284295 92284949 654 0
CTCF CD4GSE12889 92250795 92251101 306 0
CTCF CD4SISSRdata 92250795 92251101 306 0
CTCF HelaGSE12889 92250923 92251080 157 0
CTCF JurkatGSE12889 92250858 92251098 240 0
CTCF G2GSE9613 92240415 92240730 315 0
CTCF G2GSE9613 92250801 92251058 257 0
FOXA1 MCF7GSE15244 92255936 92256261 325 0
Fos K562GSE19551 92262217 92262538 321 0
H3K4me2 HCT116GSE10453 92283617 92284242 625 0
H3K4me3 colorectalcancer 92283617 92284343 726 0
H3ac HepG2E 92283617 92284510 893 0
Myc K562GSE19551 92275821 92276084 263 0
Oct1 H2O2-HelaGSE14283 92254887 92254973 86 0
Oct1 HelaGSE14283 92254887 92254930 43 0
P300 T0-glioblastomaGSE21026 92265916 92266528 612 0
P300 T30-glioblastomaGSE21026 92265788 92266652 864 0
PHF8 HeLaGSE20725 92284105 92285040 935 0
PHF8 Hs68plusFBSGSE20725 92283668 92285152 1484 0
RARA MCF7GSE15244 92255856 92256261 405 0
RARG MCF7GSE15244 92256010 92256261 251 0
RARG MCF7GSE15244 92283869 92284313 444 0
Rb QuiescentGSE19898 92254696 92254833 137 0
TAF HelaGSE8489 92283617 92284277 660 0
VDR GM10855-stimGSE22484 92239767 92241445 1678 0
hScc1 BcellGSE12603 92250587 92251058 471 0
hScc1 BcellGSE12603 92265060 92265382 322 0
hScc1 BcellGSE12603 92284201 92284897 696 0
hScc1 CdLSGSE12603 92250455 92251058 603 0
hScc1 CdLSGSE12603 92283617 92284932 1315 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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