AutismKB 2.0

Annotation Detail for PAK6


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Basic Information Top
Gene Symbol:PAK6 ( PAK5 )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 6
Band: 15q15.1
Quick LinksEntrez ID:56924; OMIM: 608110; Uniprot ID:PAK6_HUMAN; ENSEMBL ID: ENSG00000137843; HGNC ID: 16061
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
560Phosphoserine.
Location(AA) Modifications Resource
165Phosphoserine (MAPK14)Phospho.ELM 6.0
560Phosphoserine.Swiss-Prot 53.0
560PhosphoserinePhospho.ELM 6.0
564Phosphothreonine (MAP2K6)Phospho.ELM 6.0
566Phosphotyrosine (MAP2K6)Phospho.ELM 6.0
Location(AA) Modification Resource
104Phosphoserine(CDC2)HMM predict
106Phosphothreonine(PKC)HMM predict
107Phosphoserine(PKC)HMM predict
107Phosphoserine(PKC)HMM predict
129Phosphotyrosine(EGFR)HMM predict
165Phosphoserine(MAPK)HMM predict
240MethylarginineHMM predict
246Phosphoserine(CDK)HMM predict
248Phosphoserine(CDC2)HMM predict
248Phosphoserine(CDK)HMM predict
271O-linkedHMM predict
275O-linkedHMM predict
275O-linkedHMM predict
276O-linkedHMM predict
277Phosphoserine(CK1)HMM predict
277O-linkedHMM predict
277O-linkedHMM predict
288N-linkedHMM predict
289Phosphoserine(CDC2)HMM predict
319Phosphoserine(CDC2)HMM predict
322O-linkedHMM predict
323O-linkedHMM predict
326O-linkedHMM predict
328Phosphoserine(CDC2)HMM predict
328Phosphoserine(CDK)HMM predict
346O-linkedHMM predict
347Phosphoserine(IKK)HMM predict
347Phosphoserine(CDC2)HMM predict
429O-linkedHMM predict
560Phosphoserine(IKK)HMM predict
560Phosphoserine(PKA)HMM predict
578Phosphotyrosine(INSR)HMM predict
603O-linkedHMM predict
605Phosphoserine(CDC2)HMM predict
616Phosphoserine(CDK)HMM predict
616Phosphoserine(CDC2)HMM predict
669ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020168
  • Location:chr15 38319367-38356978
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 38318712 38319204 492 410
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 38358763 38359271 508 2039
CTCF G2GSE9613 38361235 38362400 1165 4839
Myc hESGSE17917 38361643 38362047 404 4867
hScc1 BcellGSE12603 38358726 38359643 917 2206
hScc1 BcellGSE12603 38361051 38362784 1733 4939
hScc1 CdLSGSE12603 38358617 38359307 690 1984
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 38354230 38354628 398 0
CTCF CD4SISSRdata 38354230 38354628 398 0
CTCF JurkatGSE12889 38354129 38354600 471 0
CTCF G2GSE9613 38318971 38320100 1129 0
CTCF G2GSE9613 38324635 38324973 338 0
CTCF G2GSE9613 38332647 38332934 287 0
CTCF G2GSE9613 38336400 38336761 361 0
CTCF G2GSE9613 38345521 38345895 374 0
CTCF G2GSE9613 38351328 38353109 1781 0
CTCF G2GSE9613 38353747 38354647 900 0
Fos K562GSE19551 38346269 38346808 539 0
Oct1 HelaGSE14283 38333525 38333566 41 0
P300 T30-glioblastomaGSE21026 38346082 38346931 849 0
TFAP2C MCF7GSE21234 38346349 38346648 299 0
hScc1 BcellGSE12603 38319347 38320000 653 0
hScc1 BcellGSE12603 38328154 38328333 179 0
hScc1 BcellGSE12603 38336473 38336761 288 0
hScc1 BcellGSE12603 38337673 38338278 605 0
hScc1 BcellGSE12603 38343925 38344361 436 0
hScc1 BcellGSE12603 38345415 38346108 693 0
hScc1 BcellGSE12603 38347956 38348091 135 0
hScc1 BcellGSE12603 38351366 38352003 637 0
hScc1 BcellGSE12603 38352468 38352858 390 0
hScc1 BcellGSE12603 38353747 38354491 744 0
hScc1 CdLSGSE12603 38354001 38354747 746 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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