Annotation Detail for PDXP

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Basic Information Top

Gene Symbol:	PDXP ( CIN,FLJ32703,PLP,dJ37E16.5 )
Gene Full Name:	pyridoxal (pyridoxine, vitamin B6) phosphatase
Band:	22q13.1
Quick Links	Entrez ID:57026; OMIM: 609246; Uniprot ID:PLPP_HUMAN; ENSEMBL ID: ENSG00000100092; HGNC ID: 30259
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:3 results

No data

Location(AA)	Modification	Resource
59	N-linked	HMM predict
60	N-linked	HMM predict
190	Phosphothreonine(MAPK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_020315
Location:chr22 36384682-36392884
strand:+

Upstream the gene:9 results
Downstream the gene:2 results
Inside the gene:11 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	36383885	36384947	1062	267
H3ac	HepG2	E	36383494	36384173	679	849
Rb	Growing	GSE19898	36384162	36384395	233	404
Rb	Growing	GSE19898	36384499	36384671	172	98
Rb	Quiescent	GSE19898	36384584	36384729	145	26
Rb	Senescent	GSE19898	36384420	36384742	322	102
Rb	shRbQuiescent	GSE19898	36384119	36384392	273	427
p130	Senescent	GSE19898	36384316	36384690	374	180
p130	shRbSenescent	GSE19898	36384406	36384698	292	131

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	36393901	36394437	536	1285
P300	T30-glioblastoma	GSE21026	36395242	36396200	958	2837

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	36387101	36387360	259	0
CTCF	CD4	SISSRdata	36387101	36387360	259	0
CTCF	G2	GSE9613	36384593	36385216	623	0
H3ac	HepG2	E	36386229	36387786	1557	0
PHF8	HeLa	GSE20725	36384532	36385720	1188	0
PolII	HeLa	GSE12783	36383198	36386453	3255	0
Rb	shRbSenescence	GSE19898	36387288	36387579	291	0
hScc1	Bcell	GSE12603	36384279	36385252	973	0
hScc1	Bcell	GSE12603	36387020	36387546	526	0
hScc1	CdLS	GSE12603	36387056	36387580	524	0
p130	shRbSenescent	GSE19898	36387164	36387310	146	0

Validated miRNA targets

miR Walk:6 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7c	hsa-let-7c	21	20736742
hsa-let-7c*	hsa-let-7c	21	20736742
hsa-miR-125b	hsa-mir-125b-1	11	20736742
hsa-miR-125b	hsa-mir-125b-2	21	20736742
hsa-miR-218	hsa-mir-218-1	4	21309487
hsa-miR-218	hsa-mir-218-2	5	21309487

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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