AutismKB 2.0

Annotation Detail for CASC5


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Basic Information Top
Gene Symbol:CASC5 ( AF15Q14,CT29,D40,KIAA1570,KNL1,hKNL-1,hSpc105 )
Gene Full Name: cancer susceptibility candidate 5
Band: 15q14
Quick LinksEntrez ID:57082; OMIM: 609173; Uniprot ID:CASC5_HUMAN; ENSEMBL ID: ENSG00000137812; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
32Phosphoserine.
60Phosphoserine.
505Phosphoserine.
513Phosphothreonine.
539Phosphothreonine.
578Phosphoserine.
601Phosphothreonine.
682Phosphoserine.
765Phosphoserine.
767Phosphoserine.
954Phosphothreonine.
956Phosphoserine.
1039Phosphoserine.
1042Phosphothreonine.
1076Phosphoserine.
1232Phosphoserine.
1720Phosphoserine.
1773Phosphoserine.
1803Nuclear localization signal (Potential).
1845Phosphoserine.
1869Phosphoserine.
1879Phosphothreonine.
Location(AA) Modifications Resource
32Phosphoserine.Swiss-Prot 53.0
32PhosphoserinePhospho.ELM 6.0
60Phosphoserine.Swiss-Prot 53.0
60PhosphoserinePhospho.ELM 6.0
765Phosphoserine.Swiss-Prot 53.0
765PhosphoserinePhospho.ELM 6.0
767Phosphoserine.Swiss-Prot 53.0
767PhosphoserinePhospho.ELM 6.0
956PhosphoserinePhospho.ELM 6.0
956Phosphoserine.Swiss-Prot 53.0
1039Phosphoserine.Swiss-Prot 53.0
1039PhosphoserinePhospho.ELM 6.0
1042PhosphothreoninePhospho.ELM 6.0
1042Phosphothreonine.Swiss-Prot 53.0
1076PhosphoserinePhospho.ELM 6.0
1076Phosphoserine.Swiss-Prot 53.0
1773Phosphoserine.Swiss-Prot 53.0
1773PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
6Phosphoserine(CK2)HMM predict
24Phosphoserine(PKA)HMM predict
24PhosphoserineHMM predict
24Phosphoserine(PKA)HMM predict
41N-linkedHMM predict
60Phosphoserine(PKA)HMM predict
60Phosphoserine(PKC)HMM predict
60Phosphoserine(PKG)HMM predict
60Phosphoserine(CAMK2)HMM predict
60Phosphoserine(IKK)HMM predict
60Phosphoserine(PKB)HMM predict
60PhosphoserineHMM predict
107Phosphoserine(IKK)HMM predict
153Phosphoserine(CK1)HMM predict
207Phosphoserine(IKK)HMM predict
232N-linkedHMM predict
233Phosphothreonine(CK2)HMM predict
234Phosphoserine(CK2)HMM predict
237N-linkedHMM predict
250Phosphothreonine(PKC)HMM predict
276Phosphoserine(IKK)HMM predict
278Phosphoserine(CK1)HMM predict
292N-linkedHMM predict
293N-linkedHMM predict
295N-linkedHMM predict
308N-linkedHMM predict
350N-linkedHMM predict
361N-linkedHMM predict
367N-linkedHMM predict
371N-linkedHMM predict
386N-linkedHMM predict
438Phosphothreonine(CDC2)HMM predict
443Phosphotyrosine(INSR)HMM predict
443Phosphotyrosine(SRC)HMM predict
443Phosphotyrosine(Syk)HMM predict
445N-linkedHMM predict
484N-linkedHMM predict
485Phosphotyrosine(INSR)HMM predict
485Phosphotyrosine(Syk)HMM predict
486Phosphoserine(INSR)HMM predict
489Phosphotyrosine(INSR)HMM predict
496Phosphoserine(CK1)HMM predict
504Phosphotyrosine(INSR)HMM predict
539Phosphothreonine(CDC2)HMM predict
539Phosphothreonine(MAPK)HMM predict
539Phosphothreonine(CDK)HMM predict
539PhosphothreonineHMM predict
623Phosphoserine(CK2)HMM predict
625Phosphoserine(CK1)HMM predict
629Phosphoserine(CK1)HMM predict
629Phosphoserine(ATM)HMM predict
629Phosphoserine(IKK)HMM predict
631Phosphoserine(IKK)HMM predict
720O-linkedHMM predict
731Phosphoserine(CDK)HMM predict
765Phosphoserine(IKK)HMM predict
767Phosphoserine(IKK)HMM predict
768N-linkedHMM predict
837Phosphoserine(CDC2)HMM predict
847Phosphoserine(IKK)HMM predict
1008Phosphoserine(IKK)HMM predict
1013O-linkedHMM predict
1017O-linkedHMM predict
1017Phosphothreonine(MAPK)HMM predict
1017PhosphothreonineHMM predict
1037N-linkedHMM predict
1042Phosphothreonine(MAPK)HMM predict
1086Phosphoserine(CK1)HMM predict
1093Phosphoserine(PKA)HMM predict
1186N-linkedHMM predict
1264N-linkedHMM predict
1268N-linkedHMM predict
1327N-linkedHMM predict
1328Phosphotyrosine(INSR)HMM predict
1328Phosphotyrosine(Jak)HMM predict
1333N-linkedHMM predict
1376Phosphotyrosine(Syk)HMM predict
1427N-linkedHMM predict
1464Phosphotyrosine(Jak)HMM predict
1506N-linkedHMM predict
1644Phosphoserine(CK2)HMM predict
1688N-linkedHMM predict
1717Phosphoserine(CK1)HMM predict
1730N-linkedHMM predict
1734Phosphoserine(ATM)HMM predict
1736Phosphotyrosine(INSR)HMM predict
1750N-linkedHMM predict
1751Phosphoserine(CK1)HMM predict
1751PhosphoserineHMM predict
1756N-linkedHMM predict
1839N-linkedHMM predict
1845Phosphoserine(CK2)HMM predict
1845Phosphoserine(IKK)HMM predict
1845Phosphoserine(PKB)HMM predict
1846Phosphoserine(IKK)HMM predict
1849Phosphoserine(CK1)HMM predict
1915Phosphoserine(PKG)HMM predict
1920N-linkedHMM predict
1924N-linkedHMM predict
1928Phosphothreonine(MAPK)HMM predict
1928Phosphothreonine(CDK)HMM predict
1935Phosphoserine(ATM)HMM predict
1963Phosphoserine(PKG)HMM predict
2008Phosphothreonine(PKA)HMM predict
2090Phosphothreonine(CK2)HMM predict
2121N-linkedHMM predict
2131Phosphoserine(CK1)HMM predict
2230Phosphoserine(CK1)HMM predict
2303N-linkedHMM predict
2331Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_144508
  • Location:chr15 38673738-38743828
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 38669210 38669534 324 4367
CTCF CD4SISSRdata 38669210 38669534 324 4367
CTCF HelaGSE12889 38669300 38669499 199 4339
CTCF JurkatGSE12889 38669324 38669495 171 4329
LIN54 SGSE7516 38672902 38674136 1234 220
LIN9 SGSE7516 38673143 38674321 1178 7
Oct4 hESGSE17917 38673316 38673587 271 287
P300 T0-glioblastomaGSE21026 38672929 38674024 1095 262
P300 T30-glioblastomaGSE21026 38672890 38674417 1527 85
PHF8 Hs68minusFBSGSE20725 38672937 38673961 1024 290
Pol3 GM12878GSE19551 38672924 38673841 917 356
Pol3 K562GSE19551 38673142 38673862 720 237
TAF HelaGSE8489 38663829 38664295 466 9677
TAF HelaGSE8489 38672839 38673994 1155 322
hScc1 CdLSGSE12603 38669206 38669473 267 4399
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 38758601 38758828 227 14886
CTCF CD4SISSRdata 38758601 38758828 227 14886
CTCF JurkatGSE12889 38758605 38758806 201 14877
ER Fulvestrant-MCF7GSE14664 38746656 38746691 35 2845
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 38697467 38697673 206 0
E2F4 G0GSE7516 38673264 38674358 1094 0
E2F4 SGSE7516 38673413 38674225 812 0
H3ac HepG2E 38673653 38674136 483 0
H3ac HepG2E 38674594 38674989 395 0
LIN54 G0GSE7516 38673413 38674358 945 0
LIN9 G0GSE7516 38673179 38674495 1316 0
Oct1 H2O2-HelaGSE14283 38719567 38719597 30 0
Oct1 H2O2-HelaGSE14283 38722452 38722480 28 0
Oct1 HelaGSE14283 38719568 38719614 46 0
P300 T30-glioblastomaGSE21026 38712448 38713316 868 0
PHF8 Hs68plusFBSGSE20725 38673086 38674413 1327 0
hScc1 BcellGSE12603 38673935 38674225 290 0
p130 QuiescentGSE19898 38673270 38674329 1059 0
p130 SenescentGSE19898 38673271 38674254 983 0
p130 shRbQuiescentGSE19898 38673271 38674248 977 0
p130 shRbSenescentGSE19898 38673354 38674376 1022 0
p130 G0GSE7516 38673179 38674426 1247 0
p130 SGSE7516 38673449 38674358 909 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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