AutismKB 2.0

Annotation Detail for RTN4


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Basic Information Top
Gene Symbol:RTN4 ( ASY,NI220/250,NOGO,NOGO-A,NOGOC,NSP,NSP-CL,Nbla00271,Nbla10545,Nogo-B,Nogo-C,RTN-X,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C )
Gene Full Name: reticulon 4
Band: 2p16.1
Quick LinksEntrez ID:57142; OMIM: 604475; Uniprot ID:RTN4_HUMAN; ENSEMBL ID: ENSG00000115310; HGNC ID: 14085
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
7Phosphoserine.
11Phosphoserine.
12Phosphoserine.
15Phosphoserine.
107Phosphoserine.
152Phosphoserine (By similarity).
181Phosphoserine.
182Phosphoserine.
184Phosphoserine.
188Phosphothreonine.
361Phosphoserine (By similarity).
446Phosphoserine (By similarity).
860Phosphoserine (By similarity).
863Phosphoserine (By similarity).
881Phosphoserine (By similarity).
889Phosphotyrosine (By similarity).
1104N6-acetyllysine.
Location(AA) Modifications Resource
7Phosphoserine.Swiss-Prot 53.0
7PhosphoserinePhospho.ELM 6.0
15Phosphoserine.Swiss-Prot 53.0
15PhosphoserinePhospho.ELM 6.0
107PhosphoserinePhospho.ELM 6.0
107Phosphoserine.Swiss-Prot 53.0
152Phosphoserine (By similarity).Swiss-Prot 53.0
182Phosphoserine (By similarity).Swiss-Prot 53.0
184Phosphoserine.Swiss-Prot 53.0
188Phosphothreonine.Swiss-Prot 53.0
446Phosphoserine (By similarity).Swiss-Prot 53.0
860Phosphoserine (By similarity).Swiss-Prot 53.0
863Phosphoserine (By similarity).Swiss-Prot 53.0
881Phosphoserine (By similarity).Swiss-Prot 53.0
889Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
13O-linkedHMM predict
13Phosphoserine(ATM)HMM predict
15Phosphoserine(CDC2)HMM predict
15Phosphoserine(ATM)HMM predict
15Phosphoserine(IKK)HMM predict
64O-linkedHMM predict
70O-linkedHMM predict
107Phosphoserine(PKB)HMM predict
107Phosphoserine(PKC)HMM predict
107Phosphoserine(IKK)HMM predict
111O-linkedHMM predict
111Phosphoserine(CDC2)HMM predict
114O-linkedHMM predict
115O-linkedHMM predict
116O-linkedHMM predict
121O-linkedHMM predict
121Phosphoserine(CDC2)HMM predict
150O-linkedHMM predict
171O-linkedHMM predict
171O-linkedHMM predict
171O-linkedHMM predict
172O-linkedHMM predict
181Phosphoserine(PKG)HMM predict
181Phosphoserine(PKA)HMM predict
182Phosphoserine(PKB)HMM predict
184Phosphoserine(ATM)HMM predict
184Phosphoserine(IKK)HMM predict
234O-linkedHMM predict
237O-linkedHMM predict
239Phosphoserine(CDC2)HMM predict
239Phosphoserine(CDK)HMM predict
273Phosphoserine(CK1)HMM predict
277Phosphoserine(CK2)HMM predict
297Phosphotyrosine(INSR)HMM predict
297Phosphotyrosine(SRC)HMM predict
305Phosphoserine(ATM)HMM predict
307Phosphoserine(CDC2)HMM predict
384Phosphotyrosine(Syk)HMM predict
384SulfotyrosineHMM predict
438Phosphoserine(CK1)HMM predict
440Phosphoserine(CK1)HMM predict
440Phosphoserine(CK2)HMM predict
445O-linkedHMM predict
446Phosphoserine(IKK)HMM predict
474Phosphoserine(IKK)HMM predict
490N-linkedHMM predict
525Phosphoserine(CK2)HMM predict
529SulfotyrosineHMM predict
529Phosphotyrosine(Jak)HMM predict
529Phosphotyrosine(INSR)HMM predict
534N-linkedHMM predict
606Phosphothreonine(MAPK)HMM predict
608Phosphoserine(IKK)HMM predict
608Phosphoserine(CDK)HMM predict
608O-linkedHMM predict
608Phosphoserine(MAPK)HMM predict
626O-linkedHMM predict
637Phosphoserine(CDC2)HMM predict
637Phosphoserine(ATM)HMM predict
646Phosphotyrosine(INSR)HMM predict
659Phosphotyrosine(Abl)HMM predict
664Phosphoserine(CK1)HMM predict
708Phosphoserine(PKG)HMM predict
718SulfotyrosineHMM predict
718Phosphotyrosine(Syk)HMM predict
718Phosphotyrosine(INSR)HMM predict
719Phosphoserine(INSR)HMM predict
738Phosphoserine(CK2)HMM predict
770Phosphoserine(PKG)HMM predict
821Phosphothreonine(PKC)HMM predict
860Phosphoserine(ATM)HMM predict
939Phosphoserine(CK1)HMM predict
941N-linkedHMM predict
956O-linkedHMM predict
1001Phosphoserine(CK1)HMM predict
1035O-linkedHMM predict
1100N-linkedHMM predict
1180IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_007008
  • Location:chr2 55052832-55090973
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RARA MCF7GSE15244 55060005 55060710 705 0
SRF HelaGSE8489 55067168 55067509 341 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19342589
hsa-let-7a hsa-let-7a-2 11 19342589
hsa-let-7a hsa-let-7a-3 22 19342589
hsa-let-7a* hsa-let-7a-1 9 19342589
hsa-let-7a* hsa-let-7a-3 22 19342589
hsa-let-7b hsa-let-7b 22 19342589
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 19342589
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7c hsa-let-7c 21 19342589
hsa-let-7c* hsa-let-7c 21 19342589
hsa-let-7d hsa-let-7d 9 19342589
hsa-let-7d* hsa-let-7d 9 19342589
hsa-let-7e hsa-let-7e 19 19342589
hsa-let-7e* hsa-let-7e 19 19342589
hsa-let-7f hsa-let-7f-1 9 19342589
hsa-let-7f hsa-let-7f-2 X 19342589
hsa-let-7f-1* hsa-let-7f-1 9 19342589
hsa-let-7f-2* hsa-let-7f-2 X 19342589
hsa-let-7g hsa-let-7g 3 19342589
hsa-let-7g* hsa-let-7g 3 19342589
hsa-let-7i hsa-let-7i 12 19342589
hsa-let-7i* hsa-let-7i 12 19342589
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-21 hsa-mir-21 17 20417062
hsa-miR-21 hsa-mir-21 17 19342589
hsa-miR-21* hsa-mir-21 17 20417062
hsa-miR-21* hsa-mir-21 17 19342589
hsa-miR-221 hsa-mir-221 X 20417062
hsa-miR-221* hsa-mir-221 X 20417062
hsa-miR-222 hsa-mir-222 X 20417062
hsa-miR-222* hsa-mir-222 X 20417062
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1091 Unknown pSILAC miR-16 RTN4 down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000115310 n_a n_a n_a "epithelium, squamous cell, leukocyte, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
14293 EST chr2 55188656 55189163 417 mRNA RTN4 chr2 55110979 55189385Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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