AutismKB 2.0

Annotation Detail for SCYL1


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Basic Information Top
Gene Symbol:SCYL1 ( GKLP,MGC78454,NKTL,NTKL,P105,TAPK,TEIF,TRAP )
Gene Full Name: SCY1-like 1 (S. cerevisiae)
Band: 11q13.1
Quick LinksEntrez ID:57410; OMIM: 607982; Uniprot ID:NTKL_HUMAN; ENSEMBL ID: ENSG00000142186; HGNC ID: 14372
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
754Phosphoserine.
Location(AA) Modifications Resource
754Phosphoserine.Swiss-Prot 53.0
754PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
39Phosphothreonine(PKA)HMM predict
41Phosphoserine(CDC2)HMM predict
70Phosphothreonine(PKC)HMM predict
85Phosphothreonine(PKC)HMM predict
162Phosphotyrosine(INSR)HMM predict
184Phosphotyrosine(INSR)HMM predict
184Phosphotyrosine(Syk)HMM predict
184Phosphotyrosine(SRC)HMM predict
447N-linkedHMM predict
469Phosphothreonine(PKC)HMM predict
569C-linkedHMM predict
579O-linkedHMM predict
594O-linkedHMM predict
603Phosphothreonine(PKA)HMM predict
613O-linkedHMM predict
613O-linkedHMM predict
618Phosphothreonine(MAPK)HMM predict
621O-linkedHMM predict
658Phosphoserine(CK1)HMM predict
688Phosphoserine(IKK)HMM predict
691Phosphoserine(CK2)HMM predict
710O-linkedHMM predict
711Phosphoserine(ATM)HMM predict
743O-linkedHMM predict
748Phosphothreonine(PKC)HMM predict
754Phosphoserine(IKK)HMM predict
800MethionineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020680
  • Location:chr11 65049123-65062757
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 65034752 65035129 377 14183
CTCF CD4SISSRdata 65034752 65035129 377 14183
CTCF JurkatGSE12889 65034862 65035089 227 14148
H3ac HepG2E 65030381 65030804 423 18531
H3ac HepG2E 65048054 65048426 372 884
RARA MCF7GSE15244 65031207 65031927 720 17557
RARG MCF7GSE15244 65031441 65031927 486 17440
Rb GrowingGSE19898 65031070 65031316 246 17931
Rb QuiescentGSE19898 65031653 65031826 173 17384
hScc1 BcellGSE12603 65034720 65035034 314 14247
hScc1 CdLSGSE12603 65034720 65035034 314 14247
hScc1 G2GSE9613 65034720 65035034 314 14247
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 65054233 65054419 186 0
CTCF CD4SISSRdata 65054233 65054419 186 0
H3ac HepG2E 65049554 65050713 1159 0
NRSF pAbJurkat 65049153 65050959 1806 0
NRSF pAbJurkat 65054097 65055082 985 0
NRSF pAbJurkat 65059899 65061365 1466 0
PHF8 HeLaGSE20725 65049007 65049865 858 0
PHF8 Hs68plusFBSGSE20725 65049010 65050053 1043 0
TFAP2C MCF7GSE21234 65056395 65056979 584 0
USF1 HepG2E 65049340 65050563 1223 0
USF2 HepG2E 65049478 65050044 566 0
hScc1 BcellGSE12603 65062255 65062541 286 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
892 Unknown pSILAC let-7b SCYL1 down 50-25% 18668040
924 Unknown pSILAC LNA_let-7b SCYL1 up 25-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000142186 n_a n_a n_a "epithelium, lymphoblast, lymphocyte, muscle cell, leukocyte" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000142186 n_a n_a n_a "epithelium, lymphoblast, lymphocyte, muscle cell, leukocyte" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4701 mRNA SCYL1 chr11 65049158 65062750 144 HTC LTBP3 chr11 65062606 65077910Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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