AutismKB 2.0

Annotation Detail for PTGS1


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Basic Information Top
Gene Symbol:PTGS1 ( COX1,COX3,PCOX1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS )
Gene Full Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Band: 9q33.2
Quick LinksEntrez ID:5742; OMIM: 176805; Uniprot ID:PGH1_HUMAN; ENSEMBL ID: ENSG00000095303; HGNC ID: 9604
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
67N-linked (GlcNAc...) (Potential).
103N-linked (GlcNAc...) (Potential).
143N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
67N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
103N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
143N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
30Phosphothreonine(CDC2)HMM predict
30Phosphothreonine(CDK)HMM predict
63Phosphotyrosine(INSR)HMM predict
67N-linkedHMM predict
84Phosphoserine(CDC2)HMM predict
103N-linkedHMM predict
129Phosphotyrosine(Abl)HMM predict
129Phosphotyrosine(SRC)HMM predict
135Phosphotyrosine(INSR)HMM predict
160PhosphothreonineHMM predict
165O-linkedHMM predict
261Phosphotyrosine(EGFR)HMM predict
403Phosphotyrosine(EGFR)HMM predict
465Phosphotyrosine(Syk)HMM predict
562Phosphothreonine(PKC)HMM predict
576Phosphotyrosine(Jak)HMM predict
585Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000962
  • Location:chr9 124173049-124197801
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 124168041 124168580 539 4739
RARA MCF7GSE15244 124168041 124168580 539 4739
Stat6 IL-4-hr4GSE17850 124152892 124153443 551 19882
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 124204157 124205201 1044 6878
Fos K562GSE19551 124204351 124205044 693 6896
P300 T30-glioblastomaGSE21026 124204079 124205926 1847 7201
SRF HelaGSE8489 124204207 124204962 755 6783
p130 QuiescentGSE19898 124204722 124204962 240 7041
p130 SenescentGSE19898 124204241 124204983 742 6811
p130 SenescentGSE19898 124205789 124205955 166 8071
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 124181571 124181695 124 0
CTCF CD4SISSRdata 124181571 124181695 124 0
ER MCF7GSE19013 124175491 124175988 497 0
FOXA1 MCF7GSE15244 124178504 124179076 572 0
P300 T30-glioblastomaGSE21026 124186094 124186776 682 0
RARA MCF7GSE15244 124175071 124175805 734 0
RARA MCF7GSE15244 124177397 124179257 1860 0
Rb GrowingGSE19898 124176830 124177020 190 0
STAT1 HeLaGSE12783 124195345 124198109 2764 0
TFAP2C MCF7GSE21234 124175380 124175940 560 0
TFAP2C MCF7GSE21234 124185556 124186018 462 0
p130 shRbSenescentGSE19898 124177232 124177554 322 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7c hsa-let-7c 21 18006822
hsa-let-7c hsa-let-7c 21 18006822
hsa-let-7c hsa-let-7c 21 18006822
hsa-let-7c* hsa-let-7c 21 18006822
hsa-let-7c* hsa-let-7c 21 18006822
hsa-let-7c* hsa-let-7c 21 18006822
hsa-miR-10a hsa-mir-10a 17 18006822
hsa-miR-10a hsa-mir-10a 17 18006822
hsa-miR-10a hsa-mir-10a 17 18006822
hsa-miR-10a* hsa-mir-10a 17 18006822
hsa-miR-10a* hsa-mir-10a 17 18006822
hsa-miR-10a* hsa-mir-10a 17 18006822
hsa-miR-144 hsa-mir-144 17 18006822
hsa-miR-144 hsa-mir-144 17 18006822
hsa-miR-144 hsa-mir-144 17 18006822
hsa-miR-144* hsa-mir-144 17 18006822
hsa-miR-144* hsa-mir-144 17 18006822
hsa-miR-144* hsa-mir-144 17 18006822
hsa-miR-150 hsa-mir-150 19 18006822
hsa-miR-150 hsa-mir-150 19 18006822
hsa-miR-150 hsa-mir-150 19 18006822
hsa-miR-150* hsa-mir-150 19 18006822
hsa-miR-150* hsa-mir-150 19 18006822
hsa-miR-150* hsa-mir-150 19 18006822
hsa-miR-155 hsa-mir-155 21 18006822
hsa-miR-155 hsa-mir-155 21 18006822
hsa-miR-155 hsa-mir-155 21 18006822
hsa-miR-155* hsa-mir-155 21 18006822
hsa-miR-155* hsa-mir-155 21 18006822
hsa-miR-155* hsa-mir-155 21 18006822
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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