Annotation Detail for PTGS2

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	PTGS2 ( COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2 )
Gene Full Name:	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Band:	1q31.1
Quick Links	Entrez ID:5743; OMIM: 600262; Uniprot ID:PGH2_HUMAN; ENSEMBL ID: ENSG00000073756; HGNC ID: 9605
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

Top

PTM Sites from Uniprot:7 results
Experimental PTM Sites from dbPTM:4 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
53	N-linked (GlcNAc...) (Potential).
130	N-linked (GlcNAc...) (Potential).
396	N-linked (GlcNAc...) (Potential).
437	Phosphoserine (By similarity).
446	Phosphotyrosine (By similarity).
561	S-nitrosocysteine (Probable).
580	N-linked (GlcNAc...).

Location(AA)	Modifications	Resource
53	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
130	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
396	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
580	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Location(AA)	Modification	Resource
53	N-linked	HMM predict
120	Sulfotyrosine	HMM predict
152	O-linked	HMM predict
248	Phosphotyrosine(EGFR)	HMM predict
390	Phosphotyrosine(EGFR)	HMM predict
437	Phosphoserine(CAMK2)	HMM predict
452	Phosphotyrosine(Syk)	HMM predict
580	N-linked	HMM predict
586	Phosphoserine(CK2)	HMM predict
592	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_000963
Location:chr1 184907592-184916178
strand:-

Upstream the gene:5 results
Downstream the gene:2 results
Inside the gene:1 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
SRF	Hela	GSE8489	184915623	184917933	2310	600
TAF	Hela	GSE8489	184916204	184917428	1224	638
hScc1	Bcell	GSE12603	184915928	184916449	521	10
hScc1	CdLS	GSE12603	184915897	184916781	884	161
hScc1	CdLS	GSE12603	184918504	184918889	385	2518

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Nanog	hES	GSE18292	184898328	184898992	664	8933
TFAP2C	MCF7	GSE21234	184894659	184895061	402	12733

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	184915928	184916367	439	0

Validated miRNA targets

Top

miR Walk:100 results
Tarbase V5.0:2 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-101	hsa-mir-101-1	1	20965124
hsa-miR-101	hsa-mir-101-2	9	20965124
hsa-miR-101	hsa-mir-101-1	1	20712078
hsa-miR-101	hsa-mir-101-2	9	20712078
hsa-miR-101	hsa-mir-101-1	1	19891660
hsa-miR-101	hsa-mir-101-2	9	19891660
hsa-miR-101	hsa-mir-101-1	1	19133256
hsa-miR-101	hsa-mir-101-2	9	19133256
hsa-miR-101	hsa-mir-101-1	1	20965124
hsa-miR-101	hsa-mir-101-2	9	20965124
hsa-miR-101	hsa-mir-101-1	1	20712078
hsa-miR-101	hsa-mir-101-2	9	20712078
hsa-miR-101	hsa-mir-101-1	1	19891660
hsa-miR-101	hsa-mir-101-2	9	19891660
hsa-miR-101	hsa-mir-101-1	1	19133256
hsa-miR-101	hsa-mir-101-2	9	19133256
hsa-miR-10b*	hsa-mir-10b	2	19891660
hsa-miR-10b*	hsa-mir-10b	2	19891660
hsa-miR-139-5p	hsa-mir-139	11	19891660
hsa-miR-139-5p	hsa-mir-139	11	19891660
hsa-miR-146a	hsa-mir-146a	5	20522791
hsa-miR-146a	hsa-mir-146a	5	20522791
hsa-miR-146a*	hsa-mir-146a	5	20522791
hsa-miR-146a*	hsa-mir-146a	5	20522791
hsa-miR-152	hsa-mir-152	17	19891660
hsa-miR-152	hsa-mir-152	17	19891660
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	21081469
hsa-miR-16	hsa-mir-16-2	3	21081469
hsa-miR-16	hsa-mir-16-1	13	18854308
hsa-miR-16	hsa-mir-16-2	3	18854308
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-16	hsa-mir-16-1	13	21081469
hsa-miR-16	hsa-mir-16-2	3	21081469
hsa-miR-16	hsa-mir-16-1	13	18854308
hsa-miR-16	hsa-mir-16-2	3	18854308
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-16-1*	hsa-mir-16-1	13	18854308
hsa-miR-16-1*	hsa-mir-16-1	13	18854308
hsa-miR-200a	hsa-mir-200a	1	19891660
hsa-miR-200a	hsa-mir-200a	1	19891660
hsa-miR-200a*	hsa-mir-200a	1	19891660
hsa-miR-200a*	hsa-mir-200a	1	19891660
hsa-miR-200b	hsa-mir-200b	1	19891660
hsa-miR-200b	hsa-mir-200b	1	19891660
hsa-miR-200b*	hsa-mir-200b	1	19891660
hsa-miR-200b*	hsa-mir-200b	1	19891660
hsa-miR-205	hsa-mir-205	1	19891660
hsa-miR-205	hsa-mir-205	1	19891660
hsa-miR-21	hsa-mir-21	17	21081469
hsa-miR-21	hsa-mir-21	17	21081469
hsa-miR-21*	hsa-mir-21	17	21081469
hsa-miR-21*	hsa-mir-21	17	21081469
hsa-miR-26b	hsa-mir-26b	2	20100477
hsa-miR-26b	hsa-mir-26b	2	20100477
hsa-miR-26b*	hsa-mir-26b	2	20100477
hsa-miR-26b*	hsa-mir-26b	2	20100477
hsa-miR-29b	hsa-mir-29b-1	7	19891660
hsa-miR-29b	hsa-mir-29b-2	1	19891660
hsa-miR-29b	hsa-mir-29b-1	7	19891660
hsa-miR-29b	hsa-mir-29b-2	1	19891660
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-455-5p	hsa-mir-455	9	19891660
hsa-miR-455-5p	hsa-mir-455	9	19891660

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
885	Unknown	pSILAC	let-7b	PTGS2	down 50-25%	18668040
1086	Unknown	pSILAC	miR-16	PTGS2	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000073756		n_a	n_a	n_a	n_a	n_a
ENSG00000073756		n_a	n_a	n_a	n_a	n_a

Cis-Nats regulation

Top

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for PTGS2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics