AutismKB 2.0

Annotation Detail for MKL2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MKL2 ( DKFZp686J1745,FLJ31823,FLJ45623,MRTF-B,NPD001 )
Gene Full Name: MKL/myocardin-like 2
Band: 16p13.12
Quick LinksEntrez ID:57496; OMIM: 609463; Uniprot ID:MKL2_HUMAN; ENSEMBL ID: ENSG00000186260; HGNC ID: 29819
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
66Phosphoserine.
367Phosphothreonine.
370Phosphothreonine.
921Phosphoserine.
Location(AA) Modifications Resource
66Phosphoserine.Swiss-Prot 53.0
66PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
82Phosphothreonine(PKC)HMM predict
175Phosphoserine(CK2)HMM predict
185Phosphoserine(ATM)HMM predict
185Phosphoserine(IKK)HMM predict
191Phosphoserine(IKK)HMM predict
194Phosphoserine(ATM)HMM predict
197Phosphoserine(IKK)HMM predict
197O-linkedHMM predict
200Phosphoserine(IKK)HMM predict
200Phosphoserine(CDC2)HMM predict
207O-linkedHMM predict
207O-linkedHMM predict
209O-linkedHMM predict
209Phosphoserine(CDC2)HMM predict
211Phosphoserine(CDC2)HMM predict
211O-linkedHMM predict
211Phosphoserine(IKK)HMM predict
215O-linkedHMM predict
217Phosphothreonine(MAPK)HMM predict
223Phosphoserine(IKK)HMM predict
223O-linkedHMM predict
223O-linkedHMM predict
252O-linkedHMM predict
256O-linkedHMM predict
257O-linkedHMM predict
297Phosphotyrosine(INSR)HMM predict
365N-linkedHMM predict
369N-linkedHMM predict
370Phosphothreonine(CDK)HMM predict
370Phosphothreonine(MAPK)HMM predict
374N-linkedHMM predict
377Phosphothreonine(CDK)HMM predict
377Phosphothreonine(CDC2)HMM predict
440O-linkedHMM predict
462O-linkedHMM predict
464O-linkedHMM predict
469Phosphothreonine(PKC)HMM predict
481N-linkedHMM predict
487N-linkedHMM predict
495Phosphoserine(MAPK)HMM predict
495Phosphoserine(CDC2)HMM predict
497Phosphoserine(CDC2)HMM predict
502Phosphoserine(IKK)HMM predict
503Phosphoserine(IKK)HMM predict
503O-linkedHMM predict
503Phosphoserine(CK1)HMM predict
505Phosphoserine(CK1)HMM predict
525Phosphoserine(ATM)HMM predict
531Phosphoserine(CDC2)HMM predict
541O-linkedHMM predict
543Phosphoserine(ATM)HMM predict
543Phosphoserine(IKK)HMM predict
543Phosphoserine(MAPK)HMM predict
543Phosphoserine(CDC2)HMM predict
543Phosphoserine(CK1)HMM predict
608O-linkedHMM predict
638Phosphoserine(CK1)HMM predict
682Phosphoserine(IKK)HMM predict
691Phosphoserine(ATM)HMM predict
723O-linkedHMM predict
759O-linkedHMM predict
773O-linkedHMM predict
783Phosphoserine(CK1)HMM predict
823Phosphoserine(IKK)HMM predict
841Phosphothreonine(MAPK)HMM predict
841Phosphothreonine(CDK)HMM predict
841Phosphothreonine(CDC2)HMM predict
846O-linkedHMM predict
847O-linkedHMM predict
847Phosphoserine(CDC2)HMM predict
863Phosphoserine(CDC2)HMM predict
874Phosphotyrosine(EGFR)HMM predict
884Phosphothreonine(PKA)HMM predict
884O-linkedHMM predict
896Phosphoserine(ATM)HMM predict
932Phosphoserine(IKK)HMM predict
934O-linkedHMM predict
935O-linkedHMM predict
943O-linkedHMM predict
966Phosphoserine(CK1)HMM predict
1033PhosphothreonineHMM predict
1057N-linkedHMM predict
1059O-linkedHMM predict
1063Phosphothreonine(CDK)HMM predict
1063Phosphothreonine(MAPK)HMM predict
1063O-linkedHMM predict
1066O-linkedHMM predict
1067O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014048
  • Location:chr16 14072696-14268129
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 14072089 14072603 514 351
HIF1 NormHepG2 14071871 14072651 780 436
Myc hESGSE17917 14072477 14072689 212 114
Oct1 HelaGSE14283 14067077 14067105 28 5606
Oct1 HelaGSE14283 14069085 14069112 27 3598
TAF HelaGSE8489 14053082 14053287 205 19512
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 14286741 14286932 191 18707
ER E2-MCF7GSE14664 14280304 14280337 33 12191
ER Fulvestrant-MCF7GSE14664 14270844 14270875 31 2730
ER Fulvestrant-MCF7GSE14664 14280306 14280337 31 12192
Oct1 HelaGSE14283 14270847 14270884 37 2736
Oct1 HelaGSE14283 14280293 14280337 44 12186
Oct1 HelaGSE14283 14287570 14287600 30 19456
PHF8 Hs68minusFBSGSE20725 14286786 14287663 877 19095
PHF8 Hs68plusFBSGSE20725 14287017 14287983 966 19371
Pol3 GM12878GSE19551 14286903 14287703 800 19174
Pol3 K562GSE19551 14286869 14287780 911 19195
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 14250962 14251206 244 0
CTCF CD4SISSRdata 14250962 14251206 244 0
CTCF G2GSE9613 14248391 14248760 369 0
CTCF G2GSE9613 14251019 14251267 248 0
ER Fulvestrant-MCF7GSE14664 14179641 14179722 81 0
ER MCF7GSE19013 14113792 14114313 521 0
FOXA1 MCF7GSE15244 14089526 14090179 653 0
FOXA1 MCF7GSE15244 14098444 14098876 432 0
KLF4 hESGSE17917 14237852 14238020 168 0
Oct1 H2O2-HelaGSE14283 14085814 14085844 30 0
Oct1 H2O2-HelaGSE14283 14158713 14158753 40 0
Oct1 H2O2-HelaGSE14283 14183659 14183688 29 0
Oct1 H2O2-HelaGSE14283 14257763 14257794 31 0
Oct1 HelaGSE14283 14085814 14085843 29 0
Oct1 HelaGSE14283 14103941 14103973 32 0
Oct1 HelaGSE14283 14122937 14122975 38 0
Oct1 HelaGSE14283 14123773 14123815 42 0
Oct1 HelaGSE14283 14127221 14127251 30 0
Oct1 HelaGSE14283 14128425 14128470 45 0
Oct1 HelaGSE14283 14158715 14158753 38 0
Oct1 HelaGSE14283 14159668 14159697 29 0
Oct1 HelaGSE14283 14257761 14257794 33 0
P300 T0-glioblastomaGSE21026 14098147 14099170 1023 0
P300 T0-glioblastomaGSE21026 14173635 14174267 632 0
P300 T30-glioblastomaGSE21026 14173770 14174462 692 0
PHF8 HeLaGSE20725 14072157 14073345 1188 0
RARA MCF7GSE15244 14097729 14098876 1147 0
RNAII Tamoxifen-MCF7GSE14664 14158711 14158746 35 0
TFAP2C MCF7GSE21234 14098419 14098903 484 0
TFAP2C MCF7GSE21234 14113694 14114212 518 0
TFAP2C MCF7GSE21234 14118319 14118806 487 0
TFAP2C MCF7GSE21234 14173800 14174140 340 0
hScc1 BcellGSE12603 14250781 14251379 598 0
hScc1 CdLSGSE12603 14250635 14251430 795 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved