AutismKB 2.0

Annotation Detail for NLGN4X


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NLGN4X ( ASPGX2,AUTSX2,HLNX,HNLX,KIAA1260,MGC22376,NLGN,NLGN4 )
Gene Full Name: neuroligin 4, X-linked
Band: Xp22.32-p22.31
Quick LinksEntrez ID:57502; OMIM: 300427; Uniprot ID:NLGNX_HUMAN; ENSEMBL ID: ENSG00000146938; HGNC ID: 14287
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
102N-linked (GlcNAc...) (Potential).
511N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
102N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
511N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
60Phosphothreonine(MAPK)HMM predict
78Phosphotyrosine(Abl)HMM predict
80O-linkedHMM predict
102N-linkedHMM predict
118Phosphoserine(CK1)HMM predict
148Phosphotyrosine(Syk)HMM predict
152Phosphotyrosine(INSR)HMM predict
253Phosphoserine(CDK)HMM predict
258O-linkedHMM predict
264Phosphothreonine(PKC)HMM predict
407Phosphotyrosine(Abl)HMM predict
409SulfotyrosineHMM predict
415Phosphothreonine(PKC)HMM predict
435Phosphothreonine(PKC)HMM predict
439Phosphothreonine(PKA)HMM predict
439Phosphothreonine(PKC)HMM predict
610O-linkedHMM predict
625Phosphothreonine(PKC)HMM predict
628Phosphoserine(CDC2)HMM predict
642O-linkedHMM predict
678O-linkedHMM predict
712Phosphoserine(CDC2)HMM predict
716N-linkedHMM predict
719N-linkedHMM predict
745Phosphoserine(CK1)HMM predict
763Phosphothreonine(PKC)HMM predict
803N-linkedHMM predict
806N-linkedHMM predict
810GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020742
  • Location:chrX 5818084-6155887
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 5813740 5813768 28 4331
hScc1 BcellGSE12603 5805254 5805671 417 12622
hScc1 CdLSGSE12603 5805093 5805671 578 12703
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 6043974 6044479 505 0
CTCF CD4GSE12889 5949478 5949683 205 0
CTCF CD4SISSRdata 5949478 5949683 205 0
ER E2-MCF7GSE14664 5824680 5824715 35 0
ER Fulvestrant-MCF7GSE14664 5824678 5824712 34 0
NRSF JurkatGSE13047 5893441 5893868 427 0
NRSF JurkatSISSRdata 5893561 5893749 188 0
NRSF mAbJurkat 5892871 5894223 1352 0
NRSF-mono JurkatQuESTdata 5893461 5893800 339 0
NRSF-poly JurkatQuESTdata 5893441 5893868 427 0
Nanog hESGSE18292 5954543 5954961 418 0
Oct1 H2O2-HelaGSE14283 5843425 5843455 30 0
Oct1 H2O2-HelaGSE14283 5866405 5866433 28 0
Oct1 HelaGSE14283 5824677 5824723 46 0
Oct1 HelaGSE14283 5824772 5824810 38 0
Oct1 HelaGSE14283 5828454 5828481 27 0
Oct1 HelaGSE14283 5866350 5866433 83 0
Oct1 HelaGSE14283 5869263 5869297 34 0
Oct1 HelaGSE14283 6009546 6009586 40 0
Oct1 HelaGSE14283 6025197 6025274 77 0
Oct1 HelaGSE14283 6043299 6043332 33 0
Oct1 HelaGSE14283 6044915 6044975 60 0
Oct1 HelaGSE14283 6046139 6046189 50 0
Oct1 HelaGSE14283 6139047 6139074 27 0
Oct1 HelaGSE14283 6139983 6140012 29 0
hScc1 BcellGSE12603 5949298 5949835 537 0
hScc1 BcellGSE12603 6064817 6064999 182 0
hScc1 CdLSGSE12603 5949298 5949986 688 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181b hsa-mir-181b-1 1 20868653
hsa-miR-181b hsa-mir-181b-2 9 20868653
hsa-miR-486-3p hsa-mir-486 8 20868653
hsa-miR-486-5p hsa-mir-486 8 20868653
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
27328 mRNA chrX 6004134 6008068 159 mRNA NLGN4X chrX 5667820 6005624Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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