Annotation Detail for XPO5

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Basic Information Top

Gene Symbol:	XPO5 ( FLJ14239,FLJ32057,FLJ45606,KIAA1291 )
Gene Full Name:	exportin 5
Band:	6p21.1
Quick Links	Entrez ID:57510; OMIM: 607845; Uniprot ID:XPO5_HUMAN; ENSEMBL ID: ENSG00000124571; HGNC ID: 17675
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:3 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:23 results

Location(AA)	Modification
2	N-acetylalanine.
396	N6-acetyllysine.
826	Phosphoserine.

Location(AA)	Modification	Resource
24	N-linked	HMM predict
47	S-palmitoyl	HMM predict
100	N-linked	HMM predict
104	N-linked	HMM predict
212	Phosphoserine(CK2)	HMM predict
212	Phosphoserine(ATM)	HMM predict
345	Phosphothreonine(MAPK)	HMM predict
428	Phosphoserine	HMM predict
437	N-linked	HMM predict
756	Phosphoserine(ATM)	HMM predict
826	Phosphoserine(CDK)	HMM predict
826	Phosphoserine(CDC2)	HMM predict
863	Phosphotyrosine(Jak)	HMM predict
908	Phosphotyrosine(SRC)	HMM predict
928	Phosphoserine(PKG)	HMM predict
928	Phosphoserine(ATM)	HMM predict
953	Phosphoserine(ATM)	HMM predict
976	S-palmitoyl	HMM predict
977	S-palmitoyl	HMM predict
986	Phosphoserine(IKK)	HMM predict
1004	Phosphothreonine(MAPK)	HMM predict
1101	Phosphotyrosine(EGFR)	HMM predict
1135	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_020750
Location:chr6 43598052-43651641
strand:-

Upstream the gene:3 results
Downstream the gene:0 results
Inside the gene:13 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Myc	hES	GSE17917	43651516	43651902	386	68
PHF8	HeLa	GSE20725	43650844	43652540	1696	51
TAFII	hES	GSE17917	43651467	43652044	577	114

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	43651104	43651470	366
ETS1	Jurkat	GSE17954	43650854	43652422	1568
H3K4me3	colorectal	cancer	43650578	43651287	709
H3ac	HepG2	E	43614574	43614906	332
H3ac	HepG2	E	43648347	43649150	803
H3ac	HepG2	E	43650578	43651287	709
LIN54	G0	GSE7516	43647549	43647764	215
NFkBII	GM15510	GSE19485	43650248	43652554	2306
Oct1	H2O2-Hela	GSE14283	43633107	43633148	41
Oct1	Hela	GSE14283	43633109	43633146	37
TAF	k562	GSE8489	43650578	43651214	636
hScc1	Bcell	GSE12603	43614574	43615236	662
p130	shRbSenescent	GSE19898	43651341	43651714	373

Validated miRNA targets

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miR Walk:64 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-100	hsa-mir-100	11	20585341
hsa-miR-100	hsa-mir-100	11	19138993
hsa-miR-100	hsa-mir-100	11	20732906
hsa-miR-100*	hsa-mir-100	11	20585341
hsa-miR-100*	hsa-mir-100	11	19138993
hsa-miR-100*	hsa-mir-100	11	20732906
hsa-miR-124	hsa-mir-124-1	8	19138993
hsa-miR-124	hsa-mir-124-1	8	20732906
hsa-miR-124*	hsa-mir-124-1	8	19138993
hsa-miR-124*	hsa-mir-124-1	8	20732906
hsa-miR-146a	hsa-mir-146a	5	20585341
hsa-miR-146a	hsa-mir-146a	5	19138993
hsa-miR-146a	hsa-mir-146a	5	20732906
hsa-miR-146a*	hsa-mir-146a	5	20585341
hsa-miR-146a*	hsa-mir-146a	5	19138993
hsa-miR-146a*	hsa-mir-146a	5	20732906
hsa-miR-196a	hsa-mir-196a-2	12	20585341
hsa-miR-196a	hsa-mir-196a-2	12	19138993
hsa-miR-196a	hsa-mir-196a-2	12	20732906
hsa-miR-196a*	hsa-mir-196a-2	12	20585341
hsa-miR-196a*	hsa-mir-196a-2	12	19138993
hsa-miR-196a*	hsa-mir-196a-2	12	20732906
hsa-miR-219-1-3p	hsa-mir-219-1	6	20585341
hsa-miR-219-1-3p	hsa-mir-219-1	6	19138993
hsa-miR-219-1-3p	hsa-mir-219-1	6	20732906
hsa-miR-219-5p	hsa-mir-219-1	6	20585341
hsa-miR-219-5p	hsa-mir-219-1	6	19138993
hsa-miR-219-5p	hsa-mir-219-1	6	20732906
hsa-miR-26a	hsa-mir-26a-1	3	20585341
hsa-miR-26a	hsa-mir-26a-2	12	20585341
hsa-miR-26a	hsa-mir-26a-1	3	19138993
hsa-miR-26a	hsa-mir-26a-1	3	20732906
hsa-miR-26a-1*	hsa-mir-26a-1	3	20585341
hsa-miR-26a-1*	hsa-mir-26a-1	3	19138993
hsa-miR-26a-1*	hsa-mir-26a-1	3	20732906
hsa-miR-30a	hsa-mir-30a	6	19138993
hsa-miR-30a	hsa-mir-30a	6	20732906
hsa-miR-30a	hsa-mir-30a	6	19965479
hsa-miR-30a*	hsa-mir-30a	6	19138993
hsa-miR-30a*	hsa-mir-30a	6	20732906
hsa-miR-30a*	hsa-mir-30a	6	19965479
hsa-miR-30c	hsa-mir-30c-1	1	19138993
hsa-miR-30c	hsa-mir-30c-1	1	20732906
hsa-miR-30c-1*	hsa-mir-30c-1	1	19138993
hsa-miR-30c-1*	hsa-mir-30c-1	1	20732906
hsa-miR-373	hsa-mir-373	19	19138993
hsa-miR-373	hsa-mir-373	19	20732906
hsa-miR-373*	hsa-mir-373	19	19138993
hsa-miR-373*	hsa-mir-373	19	20732906
hsa-miR-423-3p	hsa-mir-423	17	20585341
hsa-miR-423-3p	hsa-mir-423	17	19138993
hsa-miR-423-3p	hsa-mir-423	17	20732906
hsa-miR-423-5p	hsa-mir-423	17	20585341
hsa-miR-423-5p	hsa-mir-423	17	19138993
hsa-miR-423-5p	hsa-mir-423	17	20732906
hsa-miR-492	hsa-mir-492	12	19138993
hsa-miR-492	hsa-mir-492	12	20732906
hsa-miR-604	hsa-mir-604	10	20585341
hsa-miR-604	hsa-mir-604	10	19138993
hsa-miR-604	hsa-mir-604	10	20732906
hsa-miR-608	hsa-mir-608	10	19138993
hsa-miR-608	hsa-mir-608	10	20732906
hsa-miR-631	hsa-mir-631	15	19138993
hsa-miR-631	hsa-mir-631	15	20732906

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for XPO5

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics