AutismKB 2.0

Annotation Detail for HECW2


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Basic Information Top
Gene Symbol:HECW2 ( DKFZp686M17164,NEDL2 )
Gene Full Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Band: 2q32.3
Quick LinksEntrez ID:57520; OMIM: NA; Uniprot ID:HECW2_HUMAN; ENSEMBL ID: ENSG00000138411; HGNC ID: 29853
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
48Phosphoserine.
852Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
24Phosphoserine(CDC2)HMM predict
36Phosphoserine(IKK)HMM predict
40N-linkedHMM predict
48Phosphoserine(CK2)HMM predict
48Phosphoserine(CK1)HMM predict
55Phosphoserine(CK1)HMM predict
59Phosphoserine(CK1)HMM predict
60Phosphoserine(CK1)HMM predict
60O-linkedHMM predict
60Phosphoserine(IKK)HMM predict
154PhosphothreonineHMM predict
158O-linkedHMM predict
208Phosphotyrosine(Jak)HMM predict
208Phosphotyrosine(Syk)HMM predict
234Phosphothreonine(PKA)HMM predict
238N-linkedHMM predict
241N-linkedHMM predict
325Phosphoserine(ATM)HMM predict
352Phosphoserine(CK2)HMM predict
352Phosphoserine(ATM)HMM predict
381Phosphothreonine(CDK)HMM predict
381Phosphothreonine(MAPK)HMM predict
389Phosphoserine(CK2)HMM predict
403O-linkedHMM predict
407Phosphoserine(CDC2)HMM predict
419Phosphotyrosine(INSR)HMM predict
465Phosphoserine(CK2)HMM predict
480Phosphoserine(CK2)HMM predict
501Phosphoserine(IKK)HMM predict
501Phosphoserine(CK1)HMM predict
540O-linkedHMM predict
559O-linkedHMM predict
559O-linkedHMM predict
570Phosphoserine(ATM)HMM predict
578Phosphoserine(IKK)HMM predict
578Phosphoserine(CK2)HMM predict
578O-linkedHMM predict
585O-linkedHMM predict
596Phosphoserine(PKB)HMM predict
596O-linkedHMM predict
596Phosphoserine(IKK)HMM predict
596Phosphoserine(PKG)HMM predict
596Phosphoserine(CAMK2)HMM predict
600Phosphoserine(CK1)HMM predict
605Phosphoserine(IKK)HMM predict
608Phosphoserine(IKK)HMM predict
608Phosphoserine(ATM)HMM predict
611Phosphoserine(CK2)HMM predict
612Phosphoserine(CK1)HMM predict
624Phosphoserine(CK1)HMM predict
626Phosphoserine(IKK)HMM predict
646N-linkedHMM predict
662Phosphoserine(PKA)HMM predict
662Phosphoserine(PKC)HMM predict
662Phosphoserine(CK1)HMM predict
676PhosphoserineHMM predict
690O-linkedHMM predict
691O-linkedHMM predict
691Phosphoserine(ATM)HMM predict
691O-linkedHMM predict
697Phosphoserine(IKK)HMM predict
742Phosphoserine(PKG)HMM predict
742Phosphoserine(PKA)HMM predict
742Phosphoserine(CK1)HMM predict
759Phosphoserine(CK2)HMM predict
830N-linkedHMM predict
839O-linkedHMM predict
941Phosphotyrosine(EGFR)HMM predict
946N-linkedHMM predict
947N-linkedHMM predict
961Phosphothreonine(PKA)HMM predict
1040Phosphoserine(PKG)HMM predict
1062O-linkedHMM predict
1067O-linkedHMM predict
1073Phosphotyrosine(INSR)HMM predict
1073Phosphotyrosine(SRC)HMM predict
1110Phosphoserine(CAMK2)HMM predict
1130Phosphoserine(CK2)HMM predict
1163Phosphoserine(CDK)HMM predict
1163Phosphoserine(CDC2)HMM predict
1167O-linkedHMM predict
1167PhosphoserineHMM predict
1167Phosphoserine(CDC2)HMM predict
1170Phosphoserine(IKK)HMM predict
1171Phosphoserine(CDC2)HMM predict
1258Phosphotyrosine(INSR)HMM predict
1277Phosphotyrosine(Syk)HMM predict
1286N-linkedHMM predict
1344Phosphoserine(CK2)HMM predict
1348Phosphotyrosine(Syk)HMM predict
1348SulfotyrosineHMM predict
1348Phosphotyrosine(INSR)HMM predict
1463N-linkedHMM predict
1464N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020760
  • Location:chr2 196772221-197165579
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 197165410 197166777 1367 514
P300 T30-glioblastomaGSE21026 197174032 197175208 1176 9041
TFAP2C MCF7GSE21234 197174357 197175274 917 9236
TFAP2C MCF7GSE21234 197180848 197181238 390 15464
TFAP2C MCF7GSE21234 197182985 197183401 416 17614
hScc1 BcellGSE12603 197165997 197166490 493 664
hScc1 G2GSE9613 197165444 197166983 1539 634
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 196768954 196769170 216 3160
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 196805724 196806448 724 0
CBP T30-glioblastomaGSE21026 196907776 196908596 820 0
CBP T30-glioblastomaGSE21026 196972830 196973791 961 0
CTCF CD4GSE12889 196910399 196910651 252 0
CTCF CD4GSE12889 197026549 197026861 312 0
CTCF CD4SISSRdata 196910399 196910651 252 0
CTCF CD4SISSRdata 197026549 197026861 312 0
CTCF G2GSE9613 196814258 196814496 238 0
CTCF G2GSE9613 196846967 196847101 134 0
CTCF G2GSE9613 196871262 196871420 158 0
CTCF G2GSE9613 196910265 196910652 387 0
CTCF G2GSE9613 197041395 197041738 343 0
CTCF G2GSE9613 197076403 197076941 538 0
ER MCF7GSE19013 197134220 197134595 375 0
FOXA1 MCF7GSE15244 196818397 196819192 795 0
FOXA1 MCF7GSE15244 196832467 196833435 968 0
FOXA1 MCF7GSE15244 196865057 196865859 802 0
FOXA1 MCF7GSE15244 196887028 196888085 1057 0
FOXA1 MCF7GSE15244 196888521 196889471 950 0
FOXA1 MCF7GSE15244 197021059 197021413 354 0
FOXA1 MCF7GSE15244 197159573 197160046 473 0
Fos K562GSE19551 197048640 197048858 218 0
Fos K562GSE19551 197073665 197074077 412 0
FoxA1 MCF7MACSdata 196832825 196833105 280 0
FoxA1 MCF7MACSdata 197159756 197160033 277 0
Myc K562GSE19551 196973016 196973488 472 0
NRSF JurkatGSE13047 196994784 196995279 495 0
NRSF JurkatSISSRdata 196994961 196995226 265 0
NRSF mAbJurkat 196994644 196995235 591 0
NRSF mAbJurkat 196995743 196995951 208 0
NRSF-mono JurkatQuESTdata 196994817 196995225 408 0
NRSF-poly JurkatQuESTdata 196994831 196995294 463 0
Nanog hESGSE18292 196928294 196928786 492 0
P300 T0-glioblastomaGSE21026 196972815 196973521 706 0
P300 T0-glioblastomaGSE21026 197054260 197054742 482 0
P300 T30-glioblastomaGSE21026 196805771 196806710 939 0
P300 T30-glioblastomaGSE21026 196888247 196889628 1381 0
P300 T30-glioblastomaGSE21026 196907770 196908916 1146 0
P300 T30-glioblastomaGSE21026 196972799 196973807 1008 0
PAX3-FKHR Rh4GSE19063 196807231 196808315 1084 0
Rb GrowingGSE19898 196973145 196973375 230 0
Rb QuiescentGSE19898 196973071 196973472 401 0
Rb SenescentGSE19898 196812737 196812932 195 0
Rb SenescentGSE19898 196973137 196973566 429 0
Rb shRbQuiescentGSE19898 196973219 196973428 209 0
Rb shRbSenescenceGSE19898 196973209 196973537 328 0
STAT1 HeLaGSE12783 196805697 196806939 1242 0
Stat6 IL-4-hr1GSE17850 196835967 196836751 784 0
TAF HelaGSE8489 197031262 197031529 267 0
TFAP2C MCF7GSE21234 196779738 196780225 487 0
TFAP2C MCF7GSE21234 196836317 196836671 354 0
TFAP2C MCF7GSE21234 196865137 196865723 586 0
TFAP2C MCF7GSE21234 197140327 197140703 376 0
hScc1 BcellGSE12603 196850061 196850365 304 0
hScc1 BcellGSE12603 196871082 196871420 338 0
hScc1 BcellGSE12603 197026477 197026859 382 0
hScc1 CdLSGSE12603 196849656 196850365 709 0
hScc1 CdLSGSE12603 196871046 196871420 374 0
hScc1 CdLSGSE12603 197026411 197026859 448 0
hScc1 G2GSE9613 196871082 196871420 338 0
hScc1 G2GSE9613 197026623 197026859 236 0
hScc1 G2GSE9613 197110394 197110522 128 0
p130 QuiescentGSE19898 196973157 196973409 252 0
p130 SenescentGSE19898 196973199 196973398 199 0
p130 shRbSenescentGSE19898 196973013 196973513 500 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
15442 EST chr2 196996660 196997153 125 mRNA HECW2 chr2 196889482 197282841Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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