AutismKB 2.0

Annotation Detail for SEMA6A


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Basic Information Top
Gene Symbol:SEMA6A ( HT018,KIAA1368,SEMA,SEMA6A1,SEMAQ,VIA )
Gene Full Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Band: 5q23.1
Quick LinksEntrez ID:57556; OMIM: 605885; Uniprot ID:SEM6A_HUMAN; ENSEMBL ID: ENSG00000092421; HGNC ID: 10738
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
33N-linked (GlcNAc...) (Potential).
49N-linked (GlcNAc...) (Potential).
65N-linked (GlcNAc...) (Potential).
282N-linked (GlcNAc...) (Potential).
434N-linked (GlcNAc...) (Potential).
461N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
33N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
49N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
65N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
282N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
434N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
461N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
33N-linkedHMM predict
34Phosphotyrosine(INSR)HMM predict
49N-linkedHMM predict
51Phosphothreonine(PKC)HMM predict
65N-linkedHMM predict
77SulfotyrosineHMM predict
141N-linkedHMM predict
146N-linkedHMM predict
206Phosphothreonine(PKC)HMM predict
228SulfotyrosineHMM predict
282N-linkedHMM predict
317O-linkedHMM predict
319Phosphotyrosine(Abl)HMM predict
340Phosphothreonine(PKC)HMM predict
348Phosphoserine(IKK)HMM predict
354O-linkedHMM predict
434N-linkedHMM predict
461N-linkedHMM predict
470Phosphoserine(CK1)HMM predict
479Phosphotyrosine(Syk)HMM predict
587O-linkedHMM predict
588O-linkedHMM predict
591O-linkedHMM predict
597Phosphotyrosine(Syk)HMM predict
615PhosphoserineHMM predict
698Phosphoserine(PKB)HMM predict
698Phosphoserine(IKK)HMM predict
698Phosphoserine(PKA)HMM predict
698Phosphoserine(PKG)HMM predict
698Phosphoserine(CAMK2)HMM predict
734Phosphothreonine(MAPK)HMM predict
757Phosphothreonine(MAPK)HMM predict
757O-linkedHMM predict
757Phosphothreonine(CDK)HMM predict
761O-linkedHMM predict
796Phosphoserine(CDC2)HMM predict
808Phosphoserine(CDC2)HMM predict
810O-linkedHMM predict
829SulfotyrosineHMM predict
829Phosphotyrosine(Syk)HMM predict
887O-linkedHMM predict
896Phosphoserine(ATM)HMM predict
933Phosphothreonine(PKC)HMM predict
952PhosphoserineHMM predict
974Phosphoserine(ATM)HMM predict
988Phosphoserine(PKA)HMM predict
1003Phosphothreonine(CDK)HMM predict
1005Phosphoserine(PKC)HMM predict
1021Phosphothreonine(PKC)HMM predict
1029S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020796
  • Location:chr5 115807150-115938397
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 115939738 115939893 155 1418
CTCF G2GSE9613 115938372 115938727 355 152
CTCF G2GSE9613 115939390 115940190 800 1393
ER Fulvestrant-MCF7GSE14664 115957144 115957189 45 18769
H3K4me3 colorectalcancer 115938727 115939531 804 732
LIN9 G0GSE7516 115942869 115943081 212 4578
Oct1 HelaGSE14283 115948304 115948345 41 9927
Oct1 HelaGSE14283 115957145 115957190 45 18770
Oct1 HelaGSE14283 115957276 115957304 28 18893
P300 T0-glioblastomaGSE21026 115938208 115938682 474 48
P300 T30-glioblastomaGSE21026 115938196 115938993 797 197
hScc1 BcellGSE12603 115939229 115940967 1738 1701
hScc1 CdLSGSE12603 115938885 115940967 2082 1529
p63 keratinocytesGSE17611 115938894 115939963 1069 1031
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 115794410 115794443 33 12724
ER E2-MCF7GSE14664 115805356 115805452 96 1747
ER Fulvestrant-MCF7GSE14664 115794411 115794446 35 12722
Nanog hESGSE18292 115801442 115802144 702 5358
Oct1 HelaGSE14283 115794409 115794450 41 12721
RNAII Tamoxifen-MCF7GSE14664 115794409 115794448 39 12722
RNAII Tamoxifen-MCF7GSE14664 115794485 115794561 76 12628
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 115848335 115848500 165 0
CTCF G2GSE9613 115923385 115923554 169 0
CTCF G2GSE9613 115935855 115936447 592 0
CTCF G2GSE9613 115936743 115937776 1033 0
NRSF JurkatSISSRdata 115809047 115809165 118 0
NRSF-mono JurkatQuESTdata 115808908 115809173 265 0
Oct1 HelaGSE14283 115835785 115835834 49 0
Oct1 HelaGSE14283 115857326 115857370 44 0
P300 T30-glioblastomaGSE21026 115817907 115819185 1278 0
RARA MCF7GSE15244 115866093 115867060 967 0
RARA MCF7GSE15244 115906974 115907649 675 0
RNAII Tamoxifen-MCF7GSE14664 115834646 115834683 37 0
RNAII Tamoxifen-MCF7GSE14664 115902646 115902736 90 0
Stat6 IL-4-hr4GSE17850 115817651 115818149 498 0
TFAP2C MCF7GSE21234 115882125 115882404 279 0
hScc1 BcellGSE12603 115811071 115811360 289 0
hScc1 BcellGSE12603 115921333 115921617 284 0
hScc1 BcellGSE12603 115935715 115936447 732 0
hScc1 BcellGSE12603 115936898 115937259 361 0
hScc1 CdLSGSE12603 115921333 115921651 318 0
p63 keratinocytesGSE17611 115881827 115882688 861 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-141 hsa-mir-141 12 20420713
hsa-miR-141* hsa-mir-141 12 20420713
hsa-miR-142-3p hsa-mir-142 17 20420713
hsa-miR-149 hsa-mir-149 2 20420713
hsa-miR-149* hsa-mir-149 2 20420713
hsa-miR-185 hsa-mir-185 22 20420713
hsa-miR-185* hsa-mir-185 22 20420713
hsa-miR-200a* hsa-mir-200a 1 20420713
hsa-miR-200c hsa-mir-200c 12 20420713
hsa-miR-200c* hsa-mir-200c 12 20420713
hsa-miR-21 hsa-mir-21 17 20420713
hsa-miR-21* hsa-mir-21 17 20420713
hsa-miR-224 hsa-mir-224 X 20420713
hsa-miR-34a hsa-mir-34a 1 20420713
hsa-miR-34a* hsa-mir-34a 1 20420713
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21355 EST chr5 115811092 115813387 294 mRNA SEMA6A chr5 115807150 115938398Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018