AutismKB 2.0

Annotation Detail for PTMA


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Basic Information Top
Gene Symbol:PTMA ( MGC104802,TMSA )
Gene Full Name: prothymosin, alpha
Band: 2q37.1
Quick LinksEntrez ID:5757; OMIM: 188390; Uniprot ID:PTMA_HUMAN; ENSEMBL ID: ENSG00000187514; HGNC ID: 9623
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2Phosphoserine.
2N-acetylserine.
8Phosphothreonine (By similarity).
9Phosphoserine.
10Phosphoserine.
13Phosphothreonine (By similarity).
14Phosphothreonine (By similarity).
15N6-acetyllysine.
107Phosphothreonine.
Location(AA) Modifications Resource
1PhosphoserinePhospho.ELM 6.0
2N-acetylserine.Swiss-Prot 53.0
2Phosphoserine.Swiss-Prot 53.0
7Phosphothreonine (CK2
8Phosphothreonine (By similarity).Swiss-Prot 53.0
12Phosphothreonine (CK2
13Phosphothreonine (By similarity).Swiss-Prot 53.0
13Phosphothreonine (CK2
14Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
8Phosphothreonine(CK2)HMM predict
13Phosphothreonine(CK2)HMM predict
14Phosphothreonine(CK2)HMM predict
87Phosphothreonine(PKC)HMM predict
107Phosphothreonine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002823
  • Location:chr2 232281479-232286492
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 232261916 232262144 228 19450
CTCF G2GSE9613 232265673 232266374 701 15456
CTCF G2GSE9613 232267963 232268190 227 13403
CTCF G2GSE9613 232269592 232269928 336 11720
CTCF G2GSE9613 232274342 232274832 490 6893
CTCF G2GSE9613 232279195 232281576 2381 1094
E2F4 G0GSE7516 232279855 232280424 569 1340
ER MCF7GSE19013 232280253 232281244 991 731
ETS1 JurkatGSE17954 232279197 232280802 1605 1480
H3ac HepG2E 232274306 232275386 1080 6634
H3ac HepG2E 232278946 232280886 1940 1564
LIN9 G0GSE7516 232279657 232280531 874 1386
LIN9 SGSE7516 232279820 232280424 604 1358
NFkBII GM12878GSE19485 232278781 232281736 2955 1221
P300 T0-glioblastomaGSE21026 232279529 232280556 1027 1437
P300 T30-glioblastomaGSE21026 232278889 232282185 3296 943
PHF8 HeLaGSE20725 232278939 232283533 4594 244
Rb GrowingGSE19898 232279994 232280250 256 1358
Rb GrowingGSE19898 232281082 232281342 260 268
Rb QuiescentGSE19898 232281051 232281468 417 220
Rb SenescentGSE19898 232279628 232280341 713 1495
Rb SenescentGSE19898 232280902 232281556 654 251
Rb shRbSenescenceGSE19898 232280924 232281292 368 372
TAF HelaGSE8489 232280092 232280636 544 1116
TAF k562GSE8489 232278179 232278585 406 3098
TAF k562GSE8489 232279855 232280672 817 1216
TFAP2C MCF7GSE21234 232279073 232281078 2005 1404
hScc1 BcellGSE12603 232261916 232262226 310 19409
hScc1 BcellGSE12603 232279269 232280424 1155 1633
hScc1 BcellGSE12603 232280846 232281655 809 229
p130 QuiescentGSE19898 232279613 232280847 1234 1250
p130 QuiescentGSE19898 232281058 232281485 427 208
p130 SenescentGSE19898 232279687 232280668 981 1302
p130 SenescentGSE19898 232281058 232281569 511 166
p130 shRbQuiescentGSE19898 232279291 232281453 2162 1108
p130 shRbSenescentGSE19898 232279571 232280977 1406 1206
p130 shRbSenescentGSE19898 232281050 232281567 517 171
p130 G0GSE7516 232279631 232280497 866 1416
p63 keratinocytesGSE17611 232274173 232275479 1306 6654
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 232286678 232288823 2145 1258
CTCF G2GSE9613 232289415 232289662 247 3046
CTCF G2GSE9613 232290928 232291243 315 4593
CTCF G2GSE9613 232294434 232294581 147 8015
Fos K562GSE19551 232290256 232290649 393 3960
H3ac HepG2E 232288519 232289102 583 2318
USF1 HepG2E 232288194 232290020 1826 2615
USF1 HepG2E 232290751 232291243 492 4505
USF2 HepG2E 232288328 232289382 1054 2363
VDR GM10855-UnstimGSE22484 232286199 232288848 2649 1031
VDR GM10861-UnstimGSE22484 232286315 232289036 2721 1183
VDR GM10861-stimGSE22484 232286300 232289159 2859 1237
hScc1 BcellGSE12603 232286742 232287052 310 405
hScc1 BcellGSE12603 232287844 232289037 1193 1948
hScc1 CdLSGSE12603 232287881 232288823 942 1860
hScc1 G2GSE9613 232287844 232288628 784 1744
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 232281885 232284934 3049 0
H3K4me3 colorectalcancer 232283118 232283310 192 0
Pol2 GM12878GSE19551 232278962 232284383 5421 0
hScc1 BcellGSE12603 232283008 232283702 694 0
Validated miRNA targets Top
No data
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1187 Unknown pSILAC miR-1 PTMA down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000187514 n_a n_a n_a "squamous cell, lymphocyte, muscle cell, epithelium" "benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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