AutismKB 2.0

Annotation Detail for PREX1


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Basic Information Top
Gene Symbol:PREX1 ( KIAA1415,P-REX1 )
Gene Full Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Band: 20q13.13
Quick LinksEntrez ID:57580; OMIM: 606905; Uniprot ID:PREX1_HUMAN; ENSEMBL ID: ENSG00000124126; HGNC ID: 32594
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
436Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
31O-linkedHMM predict
32O-linkedHMM predict
32Phosphoserine(IKK)HMM predict
67Phosphothreonine(PKC)HMM predict
167Phosphothreonine(PKC)HMM predict
183Phosphothreonine(PKC)HMM predict
184Phosphothreonine(PKA)HMM predict
213Phosphothreonine(CDC2)HMM predict
238N-linkedHMM predict
264N-linkedHMM predict
314Phosphothreonine(PKC)HMM predict
319Phosphoserine(IKK)HMM predict
321N-linkedHMM predict
406Phosphotyrosine(INSR)HMM predict
436Phosphoserine(PKG)HMM predict
436Phosphoserine(PKA)HMM predict
501Phosphotyrosine(Syk)HMM predict
635SulfotyrosineHMM predict
670Phosphoserine(CK2)HMM predict
686Phosphoserine(CK1)HMM predict
689N-linkedHMM predict
730Phosphotyrosine(Abl)HMM predict
755N-linkedHMM predict
758N-linkedHMM predict
761N-linkedHMM predict
801Phosphoserine(IKK)HMM predict
801Phosphoserine(PKG)HMM predict
801Phosphoserine(ATM)HMM predict
805Phosphoserine(IKK)HMM predict
806O-linkedHMM predict
893N-linkedHMM predict
949Phosphoserine(CDK)HMM predict
968S-palmitoylHMM predict
1111O-linkedHMM predict
1112O-linkedHMM predict
1126Phosphoserine(CK1)HMM predict
1171Phosphoserine(IKK)HMM predict
1175Phosphoserine(IKK)HMM predict
1189N-linkedHMM predict
1200Phosphoserine(CK2)HMM predict
1254N-linkedHMM predict
1277Phosphoserine(CK2)HMM predict
1356Phosphotyrosine(INSR)HMM predict
1356Phosphotyrosine(EGFR)HMM predict
1385Phosphoserine(CDC2)HMM predict
1385Phosphoserine(MAPK)HMM predict
1408N-linkedHMM predict
1480Phosphoserine(CDC2)HMM predict
1480Phosphoserine(MAPK)HMM predict
1483Phosphoserine(IKK)HMM predict
1505Phosphotyrosine(EGFR)HMM predict
1520O-linkedHMM predict
1655ValineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020820
  • Location:chr20 46674199-46877826
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 46891555 46892370 815 14136
CTCF G2GSE9613 46878050 46878417 367 407
H3K27me3 colorectalcancer 46878803 46879391 588 1271
LIN9 G0GSE7516 46881246 46882032 786 3813
NFkBII GM10847GSE19485 46896127 46897651 1524 19063
NFkBII GM12878GSE19485 46896036 46898114 2078 19249
Nanog ESGSE20650 46896393 46896716 323 18728
P300 T30-glioblastomaGSE21026 46891403 46892564 1161 14157
PHF8 HeLaGSE20725 46877069 46878790 1721 103
hScc1 BcellGSE12603 46878086 46878651 565 542
hScc1 BcellGSE12603 46896495 46896895 400 18869
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 46669891 46671439 1548 3535
TFAP2C MCF7GSE21234 46664401 46665779 1378 9110
TFAP2C MCF7GSE21234 46668731 46672205 3474 3732
hScc1 BcellGSE12603 46653979 46654694 715 19863
hScc1 BcellGSE12603 46657159 46657749 590 16746
hScc1 BcellGSE12603 46669957 46671439 1482 3502
hScc1 CdLSGSE12603 46670511 46671848 1337 3020
hScc1 G2GSE9613 46669891 46671882 1991 3313
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 46685710 46686015 305 0
CTCF CD4GSE12889 46707711 46707972 261 0
CTCF CD4SISSRdata 46685710 46686015 305 0
CTCF CD4SISSRdata 46707711 46707972 261 0
CTCF HelaGSE12889 46685768 46686042 274 0
CTCF JurkatGSE12889 46685762 46686124 362 0
CTCF G2GSE9613 46684801 46686339 1538 0
CTCF G2GSE9613 46706930 46708536 1606 0
CTCF G2GSE9613 46753380 46753931 551 0
ER MCF7GSE19013 46735689 46737409 1720 0
ER MCF7GSE19013 46747436 46749181 1745 0
FOXA1 MCF7GSE10845 46840462 46841650 1188 0
FOXA1 MCF7GSE15244 46755629 46756825 1196 0
FOXA1 MCF7GSE15244 46772517 46774066 1549 0
FOXA1 MCF7GSE15244 46840426 46841650 1224 0
FOXA1 MCF7GSE15244 46861444 46862166 722 0
FOXA1 eGFPGSE10845 46755629 46756825 1196 0
FOXA1 eGFPGSE10845 46772517 46774066 1549 0
FOXA1 eGFPGSE10845 46840426 46841650 1224 0
FOXA1 eGFPGSE10845 46861410 46862166 756 0
Fos K562GSE19551 46775332 46776080 748 0
Fos K562GSE19551 46783117 46783574 457 0
P300 T0-glioblastomaGSE21026 46841543 46842002 459 0
P300 T30-glioblastomaGSE21026 46687908 46689218 1310 0
RARA MCF7GSE15244 46735907 46736745 838 0
RARA MCF7GSE15244 46747636 46749316 1680 0
RARA MCF7GSE15244 46755629 46757080 1451 0
RARA MCF7GSE15244 46841117 46841650 533 0
TFAP2C MCF7GSE21234 46717607 46719342 1735 0
TFAP2C MCF7GSE21234 46733790 46737652 3862 0
TFAP2C MCF7GSE21234 46747061 46749261 2200 0
TFAP2C MCF7GSE21234 46784053 46785024 971 0
USF1 HepG2E 46774799 46776473 1674 0
VDR GM10861-stimGSE22484 46787269 46791775 4506 0
hScc1 BcellGSE12603 46684872 46686802 1930 0
hScc1 BcellGSE12603 46703055 46703570 515 0
hScc1 BcellGSE12603 46706970 46708736 1766 0
hScc1 BcellGSE12603 46712827 46713078 251 0
hScc1 BcellGSE12603 46714412 46715069 657 0
hScc1 BcellGSE12603 46715323 46715843 520 0
hScc1 BcellGSE12603 46718065 46718430 365 0
hScc1 BcellGSE12603 46718861 46719220 359 0
hScc1 BcellGSE12603 46720160 46720386 226 0
hScc1 BcellGSE12603 46723096 46723411 315 0
hScc1 BcellGSE12603 46729802 46730651 849 0
hScc1 BcellGSE12603 46732428 46732798 370 0
hScc1 BcellGSE12603 46738458 46739155 697 0
hScc1 BcellGSE12603 46748050 46748499 449 0
hScc1 BcellGSE12603 46753154 46753858 704 0
hScc1 BcellGSE12603 46756670 46757303 633 0
hScc1 BcellGSE12603 46762441 46762763 322 0
hScc1 BcellGSE12603 46788550 46789435 885 0
hScc1 BcellGSE12603 46797055 46797407 352 0
hScc1 BcellGSE12603 46799506 46799679 173 0
hScc1 BcellGSE12603 46813532 46813826 294 0
hScc1 BcellGSE12603 46822187 46822520 333 0
hScc1 BcellGSE12603 46831357 46831585 228 0
hScc1 BcellGSE12603 46833219 46833707 488 0
hScc1 BcellGSE12603 46838051 46838576 525 0
hScc1 BcellGSE12603 46839039 46839257 218 0
hScc1 BcellGSE12603 46847086 46848499 1413 0
hScc1 BcellGSE12603 46849140 46849285 145 0
hScc1 BcellGSE12603 46869026 46869298 272 0
hScc1 CdLSGSE12603 46707557 46708070 513 0
hScc1 G2GSE9613 46685122 46686502 1380 0
hScc1 G2GSE9613 46707557 46708070 513 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16485 mRNA chr20 46707008 46709247 218 mRNA PREX1 chr20 46674199 46877827Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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