AutismKB 2.0

Annotation Detail for PTPN1


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Basic Information Top
Gene Symbol:PTPN1 ( PTP1B )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 1
Band: 20q13.13
Quick LinksEntrez ID:5770; OMIM: 176885; Uniprot ID:PTN1_HUMAN; ENSEMBL ID: ENSG00000196396; HGNC ID: 9642
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
20Phosphotyrosine.
50Phosphoserine; by PKB/AKT1.
295Phosphoserine.
352Phosphoserine.
378Phosphoserine; by PKC.
386Phosphoserine; by CDK1.
393Phosphoserine (By similarity).
Location(AA) Modifications Resource
1N-acetylmethionine.Swiss-Prot 53.0
20Phosphotyrosine.Swiss-Prot 53.0
20PhosphotyrosinePhospho.ELM 6.0
50Phosphoserine (PKB
50Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
66Phosphotyrosine (EGFR;InsR)Phospho.ELM 6.0
152Phosphotyrosine (InsR)Phospho.ELM 6.0
153Phosphotyrosine (InsR)Phospho.ELM 6.0
2154-amino-3-isothiazolidinone serine (Cys-Ser) (in inhibited form).Swiss-Prot 53.0
295Phosphoserine.Swiss-Prot 53.0
352Phosphoserine.Swiss-Prot 53.0
352PhosphoserinePhospho.ELM 6.0
378Phosphoserine (by PKC).Swiss-Prot 53.0
378Phosphoserine (PKC alpha;PK)Phospho.ELM 6.0
386Phosphoserine (CDK1;CDK
386Phosphoserine (by CDC2).Swiss-Prot 53.0
393Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
66PhosphotyrosineHMM predict
66Phosphotyrosine(Syk)HMM predict
66Phosphotyrosine(EGFR)HMM predict
66Phosphotyrosine(INSR)HMM predict
152PhosphotyrosineHMM predict
153Phosphotyrosine(Jak)HMM predict
162N-linkedHMM predict
176SulfotyrosineHMM predict
187Phosphoserine(ATM)HMM predict
201Phosphoserine(CK2)HMM predict
205Phosphoserine(ATM)HMM predict
205Phosphoserine(CDK)HMM predict
352Phosphoserine(CDC2)HMM predict
365Phosphoserine(ATM)HMM predict
386Phosphoserine(CDK)HMM predict
386Phosphoserine(CDC2)HMM predict
429PhenylalanineHMM predict
430PhenylalanineHMM predict
431PhenylalanineHMM predict
432PhenylalanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002827
  • Location:chr20 48560297-48634490
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 48549337 48549769 432 10745
Fos K562GSE19551 48559771 48560489 718 168
Myc K562GSE19551 48549400 48549871 471 10662
Rb GrowingGSE19898 48548230 48548391 161 11987
Stat6 IL-4-hr4GSE17850 48551767 48552247 480 8291
USF1 HepG2E 48548101 48548493 392 12001
USF1 HepG2E 48549639 48550647 1008 10155
USF1 HepG2E 48551702 48552372 670 8261
USF2 HepG2E 48549639 48549947 308 10505
hScc1 BcellGSE12603 48554207 48554577 370 5906
p130 SenescentGSE19898 48559799 48560475 676 161
p130 shRbSenescentGSE19898 48559705 48560526 821 182
p63 keratinocytesGSE17611 48546432 48547428 996 13368
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48620512 48620693 181 0
CTCF CD4GSE12889 48625895 48626126 231 0
CTCF CD4GSE12889 48629923 48630215 292 0
CTCF CD4SISSRdata 48620512 48620693 181 0
CTCF CD4SISSRdata 48625895 48626126 231 0
CTCF CD4SISSRdata 48629923 48630215 292 0
CTCF HelaGSE12889 48625910 48626117 207 0
CTCF G2GSE9613 48625904 48626308 404 0
CTCF G2GSE9613 48629633 48630567 934 0
ER Breast-CancerGSE22609 48616028 48616723 695 0
ER Breast-CancerGSE22609 48623067 48623934 867 0
ER MCF7GSE19013 48623044 48624293 1249 0
Fos K562GSE19551 48608430 48608958 528 0
H3K4me3 colorectalcancer 48561112 48561828 716 0
H3ac HepG2E 48559666 48561828 2162 0
H3ac HepG2E 48562167 48562668 501 0
Myc K562GSE19551 48608362 48608924 562 0
Myc K562GSE19551 48620427 48620779 352 0
NFkBII GM12878GSE19485 48619727 48621115 1388 0
NFkBII GM12892GSE19485 48559549 48561755 2206 0
P300 T30-glioblastomaGSE21026 48590251 48591876 1625 0
P300 T30-glioblastomaGSE21026 48610044 48612798 2754 0
PHF8 HeLaGSE20725 48559883 48560851 968 0
hScc1 BcellGSE12603 48619792 48620571 779 0
hScc1 BcellGSE12603 48625904 48626238 334 0
hScc1 BcellGSE12603 48629526 48630383 857 0
hScc1 CdLSGSE12603 48620206 48620571 365 0
hScc1 CdLSGSE12603 48625904 48626417 513 0
hScc1 G2GSE9613 48625904 48626308 404 0
hScc1 G2GSE9613 48629428 48630312 884 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-198 hsa-mir-198 0 17849003
hsa-miR-206 hsa-mir-206 6 17849003
hsa-miR-210 hsa-mir-210 11 20837903
hsa-miR-210 hsa-mir-210 11 19826008
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16511 mRNA PTPN1 chr20 48560297 48634491 138 mRNA chr20 48620918 48627985Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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