AutismKB 2.0

Annotation Detail for HES4


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Basic Information Top
Gene Symbol:HES4 ( bHLHb42 )
Gene Full Name: hairy and enhancer of split 4 (Drosophila)
Band: 1p36.33
Quick LinksEntrez ID:57801; OMIM: 608060; Uniprot ID:HES4_HUMAN; ENSEMBL ID: ENSG00000188290; HGNC ID: 24149
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
219WRPW motif.
Location(AA) Modifications Resource
Location(AA) Modification Resource
5Phosphothreonine(MAPK)HMM predict
5Phosphothreonine(CDC2)HMM predict
10Phosphoserine(PKG)HMM predict
12O-linkedHMM predict
22O-linkedHMM predict
24Phosphothreonine(CDC2)HMM predict
24Phosphothreonine(MAPK)HMM predict
24Phosphothreonine(CDK)HMM predict
37PhosphoserineHMM predict
38Phosphoserine(PKB)HMM predict
38Phosphoserine(PKG)HMM predict
73Phosphoserine(CK1)HMM predict
158PhosphoserineHMM predict
158Phosphoserine(PKG)HMM predict
158O-linkedHMM predict
160Phosphoserine(CDC2)HMM predict
160Phosphoserine(IKK)HMM predict
173Phosphotyrosine(Syk)HMM predict
215ProlineHMM predict
218ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_021170
  • Location:chr1 924207-925332
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 924255 926907 2652 249
CTCF CD4GSE12889 927162 927363 201 1930
CTCF CD4SISSRdata 927162 927363 201 1930
CTCF JurkatGSE12889 927171 927367 196 1937
PHF8 Hs68plusFBSGSE20725 924244 926614 2370 97
Rb GrowingGSE19898 926129 926344 215 904
Rb SenescentGSE19898 927129 927339 210 1902
TFAP2C MCF7GSE21234 925085 925645 560 33
p130 QuiescentGSE19898 925334 925518 184 94
p130 QuiescentGSE19898 925658 925997 339 495
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 920714 922340 1626 2681
TFAP2C MCF7GSE21234 920886 921542 656 2994
No data
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-155 hsa-mir-155 21 20078880
hsa-miR-155* hsa-mir-155 21 20078880
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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